Results 151 to 160 of about 7,044 (182)

The quest for new cysteinyl-leukotriene and lipoxin receptors: recent clues

Pharmacology & Therapeutics, 2004
The metabolism of arachidonic acid via the 5-lipoxygenase enzymatic pathway leads to the formation of the cysteinyl-leukotrienes and lipoxins, which have been implicated in several inflammatory reactions. While these lipid mediators are responsible for a variety of effects, their actions occur through the activation of 3 specific types of cloned ...
Xavier, Norel, Charles, Brink
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International Union of Pharmacology XXXVII. Nomenclature for Leukotriene and Lipoxin Receptors

Pharmacological Reviews, 2003
The leukotrienes and lipoxins are biologically active metabolites derived from arachidonic acid. Their diverse and potent actions are associated with specific receptors. Recent molecular techniques have established the nucleotide and amino acid sequences and confirmed the evidence that suggested the existence of different G-protein-coupled receptors ...
Charles, Brink, Sven-Erik, Dahlén, Jeffrey, Drazen, Jilly F, Evans, Douglas W P, Hay, Simonetta, Nicosia, Charles N, Serhan, Takao, Shimizu, Takehiko, Yokomizo   +8 more
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The Lipoxin Receptor ALX: Potent Ligand-Specific and Stereoselective Actions in Vivo

Pharmacological Reviews, 2006
Lipoxins (LXs) and aspirin-triggered LX (ATL) are trihydroxytetraene-containing eicosanoids generated from arachidonic acid that are distinct in structure, formation, and function from the many other proinflammatory lipid-derived mediators. These endogenous eicosanoids have now emerged as founding members of the first class of lipid/chemical mediators ...
N. Chiang, C. N. Serhan, S. E. Dahlén, J. M. Drazen, D. W. P. Hay, G. Rovati, T. Shimizu, T. Yokomizo, C. Brink   +8 more
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Lipoxin, leukotriene, and PDGF receptors cross‐talk to regulate mesangial cell proliferation

The FASEB Journal, 2002
The lipoxygenase‐derived leukotrienes (LTs) are important proinflammatory lipid mediators. Lipoxins (LXs), more recently described lipoxygenase products, modulate many proinflammatory actions of LTs and have impressive proresolution properties.
Blaithin, McMahon, Derick, Mitchell, Richard, Shattock, Finian, Martin, Hugh R, Brady, Catherine, Godson   +5 more
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Lipoxins, Aspirin-Triggered 15-epi-Lipoxin Stable Analogs and Their Receptors in Anti-Inflammation: A Window for Therapeutic Opportunity

2000
LXs and 15-epimer LXs are generated during cell-cell interactions that occur during multicellular host response to inflammation, tissue injury or host defense. Results indicate that they are present in vivo during human illness and carry predominantly counter-regulatory biological actions opposing the action of well-characterized mediators of ...
C N, Serhan, B D, Levy, C B, Clish, K, Gronert, N, Chiang   +4 more
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Pro-Resolution Mediator Lipoxin A4 and its Receptor in Upper Airway Inflammation

Annals of Otology, Rhinology & Laryngology, 2013
Objectives: The resolution of inflammation is an active process controlled by several anti-inflammatory and pro-resolution mediators. Lipoxin A4, an endogenous lipid mediator, is a potential pro-resolution mediator that could attenuate inflammation. This study was conducted to elucidate the role of lipoxin A4 in upper airway inflammation.
Shino, Shimizu, Takao, Ogawa, Satoshi, Seno, Hideaki, Kouzaki, Takeshi, Shimizu   +4 more
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Lipoxin A₄:  A New Class of Ligand for the Ah Receptor

Biochemistry, 1999
The Ah receptor is a ligand-activated transcription factor that mediates many of the biological actions of a large class of environmental compounds. Support for a role of the Ah receptor in normal physiology also has been reported, but an endogenous regulating ligand has not been identified.
C M, Schaldach, J, Riby, L F, Bjeldanes
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A twist in anti-inflammation: Annexin 1 acts via the lipoxin A4 receptor

Prostaglandins, Leukotrienes and Essential Fatty Acids, 2005
The inflammatory response is a life-saving protective process mounted by the body to overcome pathogen infection and injury; however, in chronic inflammatory pathologies this response can become deregulated. The existence of specialized anti-inflammatory pathways/mediators that operate in the body to down-regulate inflammation have now emerged.
F N E, Gavins, P, Sawmynaden, B E, Chatterjee, M, Perretti   +3 more
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Role of the lipoxin A4 receptor in inflammation

2010
ZUSAMMENFASSUNG Der Lipoxin A4 Rezeptor (ALXR) wird von nahezu allen Leukozyten exprimiert und erfullt eine wichtige Funktion in der Wirtsabwehr und in entzundlichen Erkrankungen wie rheumatoide Arthritis und Asthma. Der Rezeptor bindet strukturell unterschiedliche agonistische Liganden. Dazu gehoren Peptide und Lipidmediatoren, welche vor allem
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BML-111, a Lipoxin Receptor Agonist, Attenuates Ventilator-Induced Lung Injury in Rats

Shock, 2014
Mechanical ventilation can cause structural and functional disturbances in the lung termed ventilator-induced lung injury (VILI). The aim of this study was to evaluate whether BML-111, a lipoxin receptor agonist, could attenuate VILI. Following induction of anesthesia and tracheostomy, Sprague-Dawley rats were ventilated with low tidal volume (6 mL/kg)
Hongbin, Li, Zhouyang, Wu, Dan, Feng, Jie, Gong, Chengye, Yao, Yaxin, Wang, Shiying, Yuan, Shanglong, Yao, You, Shang   +8 more
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