Results 11 to 20 of about 7,044 (182)

Lipoxin and Resolvin Receptors Transducing the Resolution of Inflammation in Cardiovascular Disease [PDF]

Frontiers in Pharmacology, 2018
A non-resolving inflammation results in a chronic inflammatory response, characteristic of atherosclerosis, abdominal aortic aneurysms and several other cardiovascular diseases. Restoring the levels of specialized proresolving mediators to drive the chronic cardiovascular inflammation toward resolution is emerging as a novel therapeutic principle.
John Pirault, John Pirault, Magnus Bäck, Magnus Bäck, Magnus Bäck   +4 more
openaire   +4 more sources

Glucocorticoids co-interact with lipoxin A4 via lipoxin A4 receptor (ALX) up-regulation

Biomedicine & Pharmacotherapy, 2007
Lipoxin A(4) (LXA(4)) is an eicosanoid which is produced via lipoxygenases and characteristic of its anti-inflammatory effect in many metabolites of arachidonic acid, which are mostly pro-inflammatory. Glucocorticoids are well known also for their strong anti-inflammatory action but induce 5-lipoxygenase, essential to synthesize leukotrienes, which are
Atsushi, Hashimoto, Yousuke, Murakami, Hidero, Kitasato, Izumi, Hayashi, Hirahito, Endo   +4 more
openaire   +4 more sources

The effectiveness of unfractionated heparin vs. low molecular weight (Enoxaparin) in Acute Respiratory Distress Syndrom (ARDS) and metabolic dysfunction: an old drug for new indication! [PDF]

BMC Immunol
Background Acute Respiratory Distress Syndrome is a lung disorder defined by the acute onset of hypoxemia, the commonest being abdominal sepsis.Many biomarkers have been studied for diagnostic prognostication and ARDS pharmacotherapy.
Delasoud S, Mojtahedzadeh M, Sharifzadeh M, Ghahremani MH, Kebriaeezadeh A, Gholami M, Sabzevari S, Sabzevari O.   +7 more
europepmc   +2 more sources

Formyl Peptide Receptors 1 and 2: Essential for Immunomodulation of Crotoxin in Human Macrophages, Unrelated to Cellular Entry. [PDF]

Cells
Crotoxin (CTX), the main toxin in Crotalus durissus terrificus venom, is a heterodimeric complex known for its antitumoral, anti-inflammatory, and immunomodulatory properties.
Pimenta LA, Kato EE, Sobral ACM, Duarte EL, Lamy MTM, Pasqualoto KFM, Sampaio SC.   +6 more
europepmc   +2 more sources

Essential lipid autacoids rewire mitochondrial energy efficiency in metabolic dysfunction‐associated fatty liver disease

Hepatology, EarlyView., 2022
Increased liver content of DHA‐derived small lipid autacoids (i.e resolvin D1 and maresin 1) associates with enhanced mitochondrial oxidative phosphorylation, fatty acid β‐oxidation and bioenergetic metabolic flux. These features provide hepatic protection from steatotic, pro‐inflammatory and fibrogenic insults.
Cristina López‐Vicario, David Sebastián, Mireia Casulleras, Marta Duran‐Güell, Roger Flores‐Costa, Ferran Aguilar, Juan José Lozano, Ingrid W. Zhang, Esther Titos, Jing X. Kang, Antonio Zorzano, Makoto Arita, Joan Clària   +12 more
wiley   +1 more source

Regulation of Inflammation and Oxidative Stress by Formyl Peptide Receptors in Cardiovascular Disease Progression

Life, 2021
G protein-coupled receptors (GPCRs) are the most important regulators of cardiac function and are commonly targeted for medical therapeutics. Formyl-Peptide Receptors (FPRs) are members of the GPCR superfamily and play an emerging role in cardiovascular ...
Valentina Maria Caso, Valentina Manzo, Tiziana Pecchillo Cimmino, Valeria Conti, Pio Caso, Gabriella Esposito, Vincenzo Russo, Amelia Filippelli, Rosario Ammendola, Fabio Cattaneo   +9 more
doaj   +1 more source

The role of the host—Neutrophil biology

Periodontology 2000, EarlyView., 2023
Abstract Neutrophilic polymorphonuclear leukocytes (neutrophils) are myeloid cells packed with lysosomal granules (hence also called granulocytes) that contain a formidable antimicrobial arsenal. They are terminally differentiated cells that play a critical role in acute and chronic inflammation, as well as in the resolution of inflammation and wound ...
Iain L. C. Chapple, Josefine Hirschfeld, Alpdogan Kantarci, Asaf Wilensky, Lior Shapira   +4 more
wiley   +1 more source

Distinguishing Features of ILC2s During Type 2 Immune Responses. [PDF]

Eur J Immunol
Group 2 innate lymphoid cells (ILC2s) are tissue‐resident cells regulated by diverse signals often emanating from surrounding nonhematopoietic cells at barrier surfaces. Their effector cytokines determine tissue homeostasis at steady state and during type 2 immunity in allergies or worm infections.
Jakob MO, Forster PM, Klose CSN.
europepmc   +2 more sources

Sex-based differences in conjunctival goblet cell responses to pro-inflammatory and pro-resolving mediators

Scientific Reports, 2022
Many conjunctival inflammatory diseases differ between the sexes and altered conjunctival goblet cells (CGCs) response is often involved. Inflammation is initiated by the release of pro-inflammatory mediators and terminated by the biosynthesis of ...
Menglu Yang, Haakon K. Fjærvoll, Ketil A. Fjærvoll, Nicholas H. Wang, Tor P. Utheim, Charles N. Serhan, Darlene A. Dartt   +6 more
doaj   +1 more source

PPAR agonists as effective adjuvants for COVID-19 vaccines, by modifying immunogenetics: a review of literature

Journal of Genetic Engineering and Biotechnology, 2021
Background Several coronavirus vaccine have been fast-tracked to halt the pandemic, the usage of immune adjuvants that can boost immunological memory has come up to the surface.
Antoine Fakhry AbdelMassih, Rahma Menshawey, Jumana H. Ismail, Reem J. Husseiny, Yousef M. Husseiny, Shenoda Yacoub, Aya Kamel, Rafeef Hozaien, Elaria Yacoub, Esraa Menshawey, Abanoub Abdelmalek, Ahmed Abouelazaem, Ahmed Elhatw, Ahmed Aboelmaaty, Alaaelrahman Shahib, Amany Mansour, Aya Kamal, Basant Mohamed, Bemen Atif, Beshoy Ghabreal, Catherine Abdelmalak, David Ibrahim, Ebtesam Elsaify, Farah Magdy, Farid G. Hanna, Hadeer Hafez, Hafsa Dahir, Kerlos Merhom, Maram Ahmed, Mariam Bishara, Mina Tawfik, Mina Youssef, Mohamed El Sharnouby, Mourad Hamouda, Musheera Ammar, Nada Ali, Nada Daniel, Nadine El-Husseiny, Noha Abdelraouf, Nuran K. Abdelhameed, Radwa Ahmed, Radwa Othman, Rahma Mohamadein, Rana Allam, Rana Elgendy, Rana Shebl, Saged Elsherbiney, Sarah Fouad, Sara Emel, Sara Owais, Sarah Hetta, Samah El-Saman, Shaimaa Abdelalim, Sherin Galal, Yara Asar, Yara Osman, Yasmeen Khalaf, Youstina Aziz, Yousra Khafagy, Nervana Gamal, Biagio Castaldi   +60 more
doaj   +1 more source