Results 21 to 30 of about 7,044 (182)

Modulation of Neutrophil Apoptosis and the Resolution of Inflammation through β2 Integrins

Frontiers in Immunology, 2013
Precise control of the neutrophil death program provides a balance between their defence functions and safe clearance, whereas impaired regulation of neutrophil death is thought to contribute to a wide range of inflammatory pathologies.
Driss eEl Kebir, Janos G Filep
doaj   +1 more source

Arachidonic acid in health and disease with focus on hypertension and diabetes mellitus: A review

Journal of Advanced Research, 2018
Arachidonic acid (AA 20:4n-6) is an essential component of cell membranes and modulates cell membrane fluidity. AA is metabolized by cyclo-oxygenase (COX), lipoxygenase (LOX) and cytochrome P450 enzymes to form several metabolites that have important ...
Undurti N. Das
doaj   +1 more source

Airway Lipoxin A ₄ Generation and Lipoxin A ₄ Receptor Expression Are Decreased in Severe Asthma [PDF]

American Journal of Respiratory and Critical Care Medicine, 2008
Airway inflammation is common in severe asthma despite antiinflammatory therapy with corticosteroids. Lipoxin A(4) (LXA(4)) is an arachidonic acid-derived mediator that serves as an agonist for resolution of inflammation.Airway levels of LXA(4), as well as the expression of lipoxin biosynthetic genes and receptors, in severe asthma.Samples of ...
Planaguma, Anna, Kazani, Shamsah, Marigowda, Gautham, Haworth, Oliver, Mariani, Thomas J., Israel, Elliot, Bleecker, Eugene R., Curran-Everett, Douglas, Erzurum, Serpil C., Calhoun, William J., Castro, Mario, Chung, Kian Fan, Gaston, Benjamin M., Jarjour, Nizar N., Busse, William W., Wenzel, Sally E., Levy, Bruce   +16 more
openaire   +3 more sources

Syntaxin interacts with arachidonic acid to prevent diabetes mellitus

Lipids in Health and Disease, 2022
Syntaxin regulates pancreatic β cell mass and participates in insulin secretion by regulating insulin exocytosis. In addition, syntaxin 4 reduces IFNγ and TNF-α signaling via NF-ĸB in islet β-cells that facilitates plasma glucose sensing and appropriate ...
Undurti N. Das
doaj   +1 more source

Eicosanoid control over antigen presenting cells in asthma [PDF]

, 2018
Asthma is a common lung disease affecting 300 million people worldwide. Allergic asthma is recognized as a prototypical Th2 disorder, orchestrated by an aberrant adaptive CD4+ T helper (Th2/Th17) cell immune response against airborne allergens, that ...
Adelroth, Aliberti, Angeli, Baratelli, Barnes, Barnig, Barrett, Barrett, Betz, Bhattacharya, Blaho, Boniface, Bourdonnay, Brash, Cai, Chang, Chen, Clarke, de, de, Doherty, Draijer, Dullaers, Dwyer, Everts, Fajt, Fedyk, Funk, Gao, Gao, Gauvreau, George, Giannattasio, Goodarzi, Guilliams, Guilliams, Hajek, Hallstrand, Hallstrand, Hamilton, Hammad, Hammad, Hammad, Hammad, Hammad, Hardy, Harizi, Harizi, Harizi, Hattori, Haworth, Hedi, Henderson, Herrerias, Hilkens, Hirai, Huang, Hunter, Idzko, Jaffar, Jaffar, Jandl, Johnston, Kalinski, Kalinski, Kalinski, Kanaoka, Kay, Khare, Khayrullina, Kolodsick, Kool, Kühn, Lambrecht, Lambrecht, Lambrecht, Lamoureux, Lauzon-Joset, Lee, Legler, Leigh, Levy, Levy, Levy, Levy, Levy, Linton, Liu, Lombardi, Lukic, Lundequist, Lynch, Machida, Maher, Manning, Maric, Medoff, Mirchandani, Miyahara, Mori, Murn, Muñoz, Nagao, Nagata, Nakano, Nataraj, Norimoto, Nothacker, Ohta, Okunishi, Oliphant, Oriss, Parameswaran, Pavord, Peters-Golden, Pettipher, Phythian-Adams, Planagumà, Plantinga, Prinz, Raymond, Rieser, Rieser, Robbiani, Rodríguez-Pinto, Rogerio, Roper, Roper, Roper, Rubio, Salimi, Samuchiwal, Samuchiwal, Scandella, Schlitzer, Schuijs, Semmrich, Serhan, Sestini, Sheibanie, Shiraishi, Shirey, Shirey, Snijdewint, Speth, Steinbrink, Sturm, Szczeklik, Tager, Tanaka, Tang, Tang, Tang, Terawaki, Thornton, Tilley, Torres, Torres, Upham, van, van, van, van, van, Vassiliou, Vieira, Walker, Wenzel, Westphalen, Willart, Williams, Xue, Yamabayashi, Yamaguchi, Yamaoka, Yang, Zasłona, Zasłona, Zhou, Zhou, Çelik   +180 more
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Update on leukotriene, lipoxin and oxoeicosanoid receptors: IUPHAR Review 7 [PDF]

British Journal of Pharmacology, 2014
The endogenous ligands for theLT, lipoxin (LX) and oxoeicosanoid receptors are bioactive products produced by the action of the lipoxygenase family of enzymes. TheLTreceptorsBLT1andBLT2, are activated byLTB4and theCysLT1andCysLT2receptors are activated by the cysteinyl‐LTs, whereas oxoeicosanoids exert their action through theOXEreceptor.
M. Bäck, W. S. Powell, S. Dahlén, J. M. Drazen, J. F. Evans, C. N. Serhan, T. Shimizu, T. Yokomizo, G.E. Rovati   +8 more
openaire   +2 more sources

A co-ultramicronized palmitoylethanolamide/luteolin composite mitigates clinical score and disease-relevant molecular markers in a mouse model of experimental autoimmune encephalomyelitis [PDF]

, 2019
Background: Persistent and/or recurrent inflammatory processes are the main factor leading to multiple sclerosis (MS) lesions. The composite ultramicronized palmitoylethanolamide, an endogenous N-acylethanolamine, combined with the flavonoid luteolin ...
Barbierato, M., Contarini, G., Facci, L., Franceschini, D., Giusti, P., Zusso, M.   +5 more
core   +1 more source

Walker 256 Tumor Growth Suppression by Crotoxin Involves Formyl Peptide Receptors and Lipoxin A4

Mediators of Inflammation, 2016
We investigated the effects of Crotoxin (CTX), the main toxin of South American rattlesnake (Crotalus durissus terrificus) venom, on Walker 256 tumor growth, the pain symptoms associated (hyperalgesia and allodynia), and participation of endogenous ...
Patrícia Brigatte, Odair Jorge Faiad, Roberta Cornélio Ferreira Nocelli, Richardt G. Landgraf, Mario Sergio Palma, Yara Cury, Rui Curi, Sandra Coccuzzo Sampaio   +7 more
doaj   +1 more source

The role of platelet microvesicles in intercellular communication. [PDF]

, 2016
In recent years, there has been exponential growth in the interest in microvesicles, which is reflected by the number of publications. Initially referred to as platelet dust by Peter Wolf in 1967, platelet microvesicles (PMV) are now recognized as ...
Edelstein, Leonard C.
core   +2 more sources

Activation of Lipoxin a4 Receptors by Aspirin-Triggered Lipoxins and Select Peptides Evokes Ligand-Specific Responses in Inflammation [PDF]

The Journal of Experimental Medicine, 2000
Lipoxin (LX) A4 and aspirin-triggered LX (ATL) are endogenous lipids that regulate leukocyte trafficking via specific LXA4 receptors (ALXRs) and mediate antiinflammation and resolution. ATL analogues dramatically inhibited human neutrophil (polymorphonuclear leukocyte [PMN]) responses evoked by a potent necrotactic peptide derived from mitochondria as ...
N, Chiang, I M, Fierro, K, Gronert, C N, Serhan   +3 more
openaire   +2 more sources