Results 51 to 60 of about 7,044 (182)

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Type 2 Innate Lymphoid Cells in Allergic Disease. [PDF]

, 2013
Type II innate lymphoid cells (ILC2) are a novel population of lineage-negative cells that produce high levels of Th2 cytokines IL-5 and IL-13. ILC2 are found in human respiratory and gastrointestinal tissue as well as in skin.
Doherty, Taylor A, Lund, Sean, Walford, Hannah H   +2 more
core   +2 more sources

Metabolic engineering of adipose‐derived stem cell exosomes via arachidonic acid potentiates diabetic wound repair by orchestrating angiogenesis: A multi‐omics guided strategy

VIEW, EarlyView.
AA‐Exos promotes angiogenesis and accelerates diabetic wound healing by activating the PI3K/AKT/mTOR pathway. Abstract Diabetic wounds are common and challenging complications of diabetes, characterized by delayed healing and an increased risk of infection.
Yujiao Cai, Jinnan Wang, Yan Liu, Xiaoke Zhu, Zhanyuan Yuan, Weiling Li, Dehui Che, Dongsheng Cao   +7 more
wiley   +1 more source

Protectin D1 and maresin 1 attenuate airway hyperreactivity induced by IL‐13 in human isolated small bronchi

British Journal of Pharmacology, EarlyView.
Background and Purpose Interleukin (IL)‐13 is implicated in airway hyperreactivity (AHR), a key feature of asthma. We explored the potential anti‐AHR activity of selected specialised pro‐resolving mediators (SPMs) in IL‐13‐induced AHR models, using human bronchial smooth muscle cells (BSMCs) and human isolated bronchi.
Willem Abma, Sven‐Erik Dahlén, Craig E. Wheelock, Mikael Adner, Mamdoh Al‐Amerie, Erik Sachs, Kasra Vali Jalali, Leonardo De Maria, Henric Olsson, Jesper Säfholm   +9 more
wiley   +1 more source

Resolution of inflammation: a new therapeutic frontier [PDF]

, 2016
Dysregulated inflammation is a central pathological process in diverse disease states. Traditionally, therapeutic approaches have sought to modulate the pro- or anti-inflammatory limbs of inflammation, with mixed success.
A Ariel, A Ariel, A Basran, A Boasso, A Chatterjee, A Devitt, A Kovalenko, A Recchiuti, A Recchiuti, A Rossi, AB Shyu, AE Leitch, AE Leitch, AG Rossi, AG Rossi, AG Rossi, AG Rossi, AI Medeiros, AJ Degraaf, AJ O'Brien, AL Alessandri, AL Alessandri, AL Robertson, AP Cope, AW Segal, B Amulic, B Bondue, B Geering, B Gemici, B Leon, BA Zabel, BJ Evans, C Favas, C Godson, C Qin, C Schauer, C von Roretz, C Yao, CA Wijbrandts, CC Mihalache, CD Buckley, CD Buckley, CD Gregory, CE Clay, CH Fong, CN Serhan, CN Serhan, CN Serhan, CW Yang, D Bhaumik, D El Kebir, D Park, DA Isenberg, DA Sawatzky, DC Cara, Derek W. Gilroy, DH Rodrigues, DR Gude, DS Straus, DW Gilroy, DW Gilroy, DW Gilroy, E Carballo, E Carballo, E Perdiguero, E Tili, EB Wilson, EE McGrath, EL Hahn, ES Mocarski, EY Chung, F Mariani, FJ Sheedy, FK Chan, FK Swirski, FM Menzies, FN Gavins, FS Machado, G D'Agostino, G Fredman, G Song, G Stoecklin, GA Rabinovich, GJ Bellingan, GJ Graham, GJ Graham, GL Bannenberg, H Braley-Mullen, H Muhl, H Nakano, H Seki, HJ Anders, HT Chung, I Allaeys, I McConnell, I Mitroulis, I Mitroulis, I Sauer, IK Poon, J Bystrom, J Bystrom, J Bystrom, J Gong, J Hopkins, J Liang, J Liu, J Liu, J Newson, J Savill, J Savill, J Seok, James N. Fullerton, JD Langereis, JD Pollock, JL Cash, JL Wallace, JM Gonzalez-Navajas, JM Schwab, JP Vago, JR Brown, JR Teijaro, JW Zmijewski, K Ersland, K Horino, K Lauber, K Linker, K Matsushita, K Miles, K Phillips, K Sasaki, K Takao, K Uchida, K Vyas, KD Taganov, KE Blume, KH Weylandt, KP High, L Arnold, L Chen, L Li, L Sun, LJ Harvey, LM Wakim, LP Sousa, LP Sousa, LR Prince, LS van Rijt, M Back, M Brittan, M Drechsler, M Feoktistova, M Kool, M Lagarde, M Mavers, M Perretti, M Perretti, M Piecyk, M Romano, M Romano, M Rosas, M Singh, M Vukmanovic-Stejic, MA Nahid, MC Martin, MF Schmidt, MG Johnston, MM Chan, MM Matzelle, MM Perry, MR Elliott, MR Jones, MR Junttila, MS Bynoe, MS Chapman, MT Elola, N Chiang, N Chiang, N Dufton, NC Henderson, NM Reddy, P Anderson, P Anderson, P Libby, P Ramachandran, P Sampath, PA Insel, Q Remijsen, R Gyurko, R Mounier, R Mukhopadhyay, R Pettipher, R Rajakariar, R Rajakariar, R Tomasini, RJ Nibbs, RL Ogilvie, RL Ogilvie, RM Day, RM Dores, RM Thurlings, RN Cahill, S Bala, S Brown, S Divanovic, S Krishnamoorthy, S Mi, S Parathath, S Schif-Zuck, S Uderhardt, S Yazid, S Yona, SB Berger, SG Trivedi, SJ Gardai, SJ Nicholls, SW Jones, SW Ryter, T Brzoska, T Hisada, T Lawrence, T Montero-Melendez, T Shay, T Vanden Berghe, U Koedel, UE Knies, V Deretic, VA Fadok, VA Fadok, VA Fadok, VA Fadok, VA Fadok, W Jenner, WH Shao, WJ Kim, WR Hansen, Y Fang, Y Fang, Y Okabe, Y Uehara, YL Chen   +239 more
core   +1 more source

1H NMR metabolomics and lipidomics analysis of neutrophils reveals biomarkers of ageing, inflammageing and frailty

The FEBS Journal, EarlyView.
Using 1H NMR metabolomics, we measured polar and lipid metabolites from human blood neutrophils from people with frailty (n = 31, mean age 84Y), people with rheumatoid arthritis (n = 16, mean age 55Y), robust older (n = 24, mean age 66Y) and healthy younger people (n = 21, mean age 22Y).
Genna Ali Abdullah, Grace Filbertine, Lucy Gill, Asangaedem Akpan, Marie M. Phelan, Helen Louise Wright   +5 more
wiley   +1 more source

Vagus nerve controls resolution and pro-resolving mediators of inflammation [PDF]

, 2015
Resolution of inflammation is now recognized as a biosynthetically active process involving pro-resolving mediators. Here, we show in zymosan-initiated peritoneal inflammation that the vagus nerve regulates local expression of netrin-1, an axonal ...
Dalli, Jesmond, Granja, Tiago, Mirakaj, Valbona, Rosenberger, Peter, Serhan, Charles N.   +4 more
core   +1 more source

Inflammatory and Immunological Basis of Periodontal Diseases

Journal of Periodontal Research, EarlyView.
The periodontal lesion emerges as an evolving immunological battlefield, where host–microbiome interactions, dysregulated immune responses, fragile resolution mechanisms, and inflammophilic dysbiosis converge to shift the balance from homeostasis to unrestrained tissue destruction.
Giacomo Baima, Marion Arce, Mario Romandini, Thomas Van Dyke   +3 more
wiley   +1 more source

Matrix Metalloproteinases in Periodontal and Peri‐Implant Diseases: Contribution to Their Pathogenesis, Diagnosis, and Treatment

Journal of Periodontal Research, EarlyView.
This graphical abstract illustrates the role of matrix metalloproteinases (MMPs) across the pathogenesis, diagnosis, and therapeutics of periodontal and peri‐implant diseases. Microbial and host stimuli trigger MMP activation leading to extracellular matrix breakdown, point‐of‐care aMMP‐8 detection aids diagnosis, and adjunctive or AI‐assisted ...
Timo Sorsa, Lorne M. Golub, Julie Toby Thomas, Pietro Leone, Sukumaran Anil, Veli‐Jukka Uitto   +5 more
wiley   +1 more source

Lipid Mediators in Inflammation [PDF]

, 2016
Lipids are potent signaling molecules that regulate a multitude of cellular responses, including cell growth and death and inflammation/infection, via receptor-mediated pathways. Derived from polyunsaturated fatty acids (PUFAs), such as arachidonic acid (
Bennett, M, Gilroy, DW
core   +1 more source