Molecular Nutrition &Food Research, Volume 70, Issue 7, 15 April 2026.Metabolic and nutritional stressors are a growing global health concern. This review discusses how obesity, lipids, and lipid derivatives influence lung development, homeostasis, and chronic lung disease progression, highlighting roles of alveolar surfactant and sphingolipids.
Jaco Selle +8 more
wiley +1 more source
Identification of a Novel Recycling Sequence in the C-tail of FPR2/ALX Receptor: Association with Cell Protection from Apoptosis [PDF]
, 2014 Formyl-peptide receptor type 2 (FPR2; also called ALX because it is the receptor for lipoxin A4) sustains a variety of biological responses relevant to the development and control of inflammation, yet the cellular regulation of this G-protein-coupled ...
Babbin +41 more
core +2 more sources
Aging Cell, Volume 25, Issue 4, April 2026.Age‐associated LPA affects adverse reactions and alters platelet and endothelial biology following platelet concentrate transfusion. Age‐associated LPC, S1P could be involved in adverse reactions, in platelet and endothelium biology following a PC transfusion.
Amelie Prier +10 more
wiley +1 more source
Biasing the lipoxin A 4 /formyl peptide receptor 2 pushes inflammatory resolution [PDF]
Proceedings of the National Academy of Sciences, 2013 Acute inflammation is an innate host-defense mechanism against invading pathogens and tissue injury. Neutralization of the offending insult ideally prompts resolution of inflammation and restoration of tissue homeostasis. Resolution of inflammation is an active process governed by resolution programs (1), involving a novel group of lipid and protein ...
openaire +2 more sources
The c.-292C>T promoter polymorphism increases reticulocyte-type 15-lipoxygenase-1 activity and could be atheroprotective [PDF]
, 2017 Background: Reticulocyte-type 15-lipoxygenase-1 (ALOX15) has anti-inflammatory and inflammatory effects and is implicated in the development of asthma, arthritis and atherosclerosis.
Bayer, Mathias +4 more
core
Bufalin Inhibits Cytokine Storm by Regulating TLR4/TLR3 Signaling Pathway
Immunity, Inflammation and Disease, Volume 14, Issue 2, February 2026.ABSTRACT Background Bufalin is one main component of the dried venom from Bufo gargarizans Cantor, which has anti‐tumor, cardiotonic, anti‐inflammatory and other physiological activities. However, in recent years, researchers have mainly paid attention to its anti‐tumor effect and neglected its anti‐inflammatory effect.
Xixi Liu +11 more
wiley +1 more source
Aspirin-triggered resolvin D1 reduces pneumococcal lung infection and inflammation in a viral and bacterial coinfection pneumonia model [PDF]
, 2015 Formyl peptide receptor 2/lipoxin A4 (LXA4) receptor (Fpr2/ALX) co-ordinates the transition from inflammation to resolution during acute infection by binding to distinct ligands including serum amyloid A (SAA) and Resolvin D1 (RvD1).
Hao Wang +40 more
core +2 more sources
Anti-tumor activities of lipids and lipid analogues and their development as potential anticancer drugs [PDF]
, 2015 © 2015 Elsevier Inc. All rights reserved. Lipids have the potential for development as anticancer agents. Endogenous membrane lipids, such as ceramides and certain saturated fatty acids, have been found to modulate the viability of tumor cells.
Bebawy, M +4 more
core +1 more source
The Formyl Peptide Receptor 2 Regulates Microglial Phenotype Through Immunometabolism: Implications for Alzheimer’s Disease [PDF]
, 2019 Microglia are key players in the pathology of Alzheimer’s disease (AD), driving chronic inflammation, oxidative stress, and the altered metabolism seen in the brains of patients.
Wickstead, E., Wickstead, E.
core
Inhibitory effects of aspirin-triggered resolvin D1 on spinal nociceptive processing in rat pain models [PDF]
, 2016 Background: Harnessing the actions of the resolvin pathways has the potential for the treatment of a wide range of conditions associated with overt inflammatory signalling.
Bennett, Andrew +4 more
core +5 more sources