Results 11 to 20 of about 15,272 (178)

IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases and is farnesoid X receptor responsive in NASH

Hepatology, EarlyView., 2022
IL‐31 levels correlate with pruritus in patients with cholestatic and metabolic liver diseases Abstract Background and Aims Pruritus is associated with multiple liver diseases, particularly those with cholestasis, but the mechanism remains incompletely understood.
Jun Xu, Ya Wang, Mina Khoshdeli, Matt Peach, Jen‐Chieh Chuang, Julie Lin, Wen‐Wei Tsai, Sangeetha Mahadevan, Wesley Minto, Lauri Diehl, Ruchi Gupta, Michael Trauner, Keyur Patel, Mazen Noureddin, Kris V. Kowdley, Aliya Gulamhusein, Christopher L. Bowlus, Ryan S. Huss, Robert P. Myers, Chuhan Chung, Andrew N. Billin   +20 more
wiley   +1 more source

Linking medicinal cannabis to autotaxin–lysophosphatidic acid signaling

Life Science Alliance, 2023
The authors show that Δ9-trans-tetrahydrocannabinol, the main psychoactive compound in medicinal cannabis, could be considered as a therapeutic agent by inhibiting autotaxin–lysophosphatidic acid production. Autotaxin is primarily known for the formation
Mathias C Eymery, Andrew A McCarthy, Jens Hausmann   +2 more
doaj   +1 more source

Lysophosphatidic acid supports the development of vitrified ovarian follicles by decreasing the incidence of cell death: An experimental study

International Journal of Reproductive BioMedicine, 2022
Background: Lysophosphatidic acid (LPA) contributes to follicular activation, oocyte maturation, in vitro fertilization, and embryo implantation. Objective: This study was designed to evaluate the effects of LPA to improve the development of isolated ...
Neda Abedpour, Nassim Ghorbanmehr, Mojdeh Salehnia   +2 more
doaj   +1 more source

Involvement of LPA Receptor 3 in LPA-induced BGC- 803 Cell Migration [PDF]

Mongolian Journal of Biological Sciences, 2013
Lysophosphatidic acid ˄ LPA ˅ is a bioactive phospholipid mediator, which elicits a variety of biological functions mainly through G-protein coupled receptors. Although LPA is shown to stimulate proliferation and motility via LPA receptors, LPAR1
Erdene Oyungerel, Tserennadmid Tseveensuren, Oyun Gansukh, Li Rui Juan, Alatangaole Damirin   +4 more
doaj   +1 more source

Lysophosphatidic Acid Signaling through the Lysophosphatidic Acid-1 Receptor Is Required for Alveolarization [PDF]

American Journal of Respiratory Cell and Molecular Biology, 2016
Abstract Lysophosphatidic acid (LPA) signaling through one of its receptors, LPA1, contributes to both the development and the pathological remodeling after injury of many organs. Because we found previously that LPA–LPA1 signaling contributes to pulmonary fibrosis, here we investigated whether this pathway is also involved in lung ...
Funke, Manuela, Knudsen, Lars, Lagares, David, Ebener, Simone, Probst, Clemens K, Fontaine, Benjamin A, Franklin, Alicia, Kellner, Manuela, Kühnel, Mark, Matthieu, Stephanie, Grothausmann, Roman, Chun, Jerold, Roberts, Jesse D, Ochs, Matthias, Tager, Andrew M   +14 more
openaire   +3 more sources

GPR35 in Intestinal Diseases: From Risk Gene to Function

Frontiers in Immunology, 2021
Diet and gut microbial metabolites mediate host immune responses and are central to the maintenance of intestinal health. The metabolite-sensing G-protein coupled receptors (GPCRs) bind metabolites and trigger signals that are important for the host cell
Berna Kaya, Hassan Melhem, Jan Hendrik Niess, Jan Hendrik Niess   +3 more
doaj   +1 more source

Neurobiology of the Edg2 Lysophosphatidic Acid Receptor

Japanese Journal of Pharmacology, 2001
Lysophosphatidic acid (LPA, 1-acyl-sn-glycerol-3-phosphate) is a well-known lipid growth factor that is found widely in various tissues including brain and is reported to drive different intracellular signaling pathways. In the nervous system, LPA studies have drawn many neuroscientists' attention because it has some actions related to neurogenesis ...
Yoshida, Akira, Ueda, Hiroshi
openaire   +3 more sources

Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors

Journal of Ginseng Research, 2021
Background: Gintonin is a ginseng-derived exogenous G-protein–coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors.
Sun-Hye Choi, Na-Eun Lee, Hee-Jung Cho, Ra Mi Lee, Hyewhon Rhim, Hyoung-Chun Kim, Mun Han, Eun-Hee Lee, Juyoung Park, Seung-Yeol Nah   +9 more
doaj   +1 more source

The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA. [PDF]

PLoS ONE, 2012
Lysophosphatidic acid (LPA) mediates diverse cellular responses through the activation of at least six LPA receptors--LPA(1-6,) but the interacting proteins and signaling pathways that mediate the specificity of these receptors are largely unknown.
Tal Varsano, Vanessa Taupin, Lixia Guo, Oscar Y Baterina, Marilyn G Farquhar   +4 more
doaj   +1 more source

The LPA-CDK5-tau pathway mediates neuronal injury in an in vitro model of ischemia-reperfusion insult

BMC Neurology, 2022
Lysophosphatidic acid (LPA) is a common glycerol phospholipid and an important extracellular signaling molecule. LPA binds to its receptors and mediates a variety of biological effects, including the pathophysiological process underlying ischemic brain ...
Yaya Wang, Jie Zhang, Liqin Huang, Yanhong Mo, Changyu Wang, Yiyi Li, Yangyang Zhang, Zhaohui Zhang   +7 more
doaj   +1 more source