Results 21 to 30 of about 2,989,463 (164)

Involvement of LPA Receptor 3 in LPA-induced BGC- 803 Cell Migration [PDF]

Mongolian Journal of Biological Sciences, 2013
Lysophosphatidic acid ˄ LPA ˅ is a bioactive phospholipid mediator, which elicits a variety of biological functions mainly through G-protein coupled receptors. Although LPA is shown to stimulate proliferation and motility via LPA receptors, LPAR1
Erdene Oyungerel, Tserennadmid Tseveensuren, Oyun Gansukh, Li Rui Juan, Alatangaole Damirin   +4 more
doaj   +1 more source

Melanoma cells break down LPA to establish local gradients that drive chemotactic dispersal. [PDF]

, 2014
The high mortality of melanoma is caused by rapid spread of cancer cells, which occurs unusually early in tumour evolution. Unlike most solid tumours, thickness rather than cytological markers or differentiation is the best guide to metastatic potential.
Gabriela Kalna (192504), William J. Faller (644356), Bennett, DC, Knecht, D, Veltman, DM, Jones, R, Andrew J Muinonen-Martin, Muinonen-Martin, Andrew J, Muinonen-Martin, AJ, Lindsay, C, Faller, William J., Douwe M Veltman, Wakelam, Michael J.O., Dorothy C Bennett, David A Knecht, Owen J Sansom, Zhang, Qifeng, Faller, WJ, Michael J O Wakelam, Machesky, Laura M, Bennett, Dorothy C., Knecht, David A, Robert Jones (270787), Gabriela Kalna, Knecht, DA, Insall, Robert H, Machesky, Laura M., Smethurst, Elizabeth, Smethurst, E, Lindsay, Colin; id_orcid, Robert Jones, Lindsay, Colin, Insall, RH, Sansom, Owen J., Elizabeth Smethurst (644355), Faller, William J, Jones, Robert, Laura M Machesky, Knecht, David A., Robert H. Insall (220984), Sansom, Owen J, Andrew J. Muinonen-Martin (235328), Michael J. O. Wakelam (116384), Sansom, OJ, Machesky, LM, Machesky, Laura, Wakelam, Michael J O, Robert Herd, Insall, Robert H., Owen J. Sansom (192366), Douwe M. Veltman (220981), Veltman, Douwe M, Wakelam, MJ, Kalna, Gabriela, Elizabeth Smethurst, Muinonen-Martin, Andrew J., Susanto, Olivia, William J Faller, Colin Lindsay, Herd, R, Zhang, Q, Susanto, O, Robert H Insall, Qifeng Zhang (116382), Laura M. Machesky (175567), Bennett, Dorothy C, Kalna, G, Robert Herd (644358), Olivia Susanto (644354), Colin Lindsay (644357), Qifeng Zhang, Herd, Robert, Dorothy C. Bennett (234520), David A. Knecht (231111), Olivia Susanto, Veltman, Douwe M., Bennett, Dorothy   +76 more
core   +1 more source

GPR35 in Intestinal Diseases: From Risk Gene to Function

Frontiers in Immunology, 2021
Diet and gut microbial metabolites mediate host immune responses and are central to the maintenance of intestinal health. The metabolite-sensing G-protein coupled receptors (GPCRs) bind metabolites and trigger signals that are important for the host cell
Berna Kaya, Hassan Melhem, Jan Hendrik Niess, Jan Hendrik Niess   +3 more
doaj   +1 more source

Neurobiology of the Edg2 Lysophosphatidic Acid Receptor

Japanese Journal of Pharmacology, 2001
Lysophosphatidic acid (LPA, 1-acyl-sn-glycerol-3-phosphate) is a well-known lipid growth factor that is found widely in various tissues including brain and is reported to drive different intracellular signaling pathways. In the nervous system, LPA studies have drawn many neuroscientists' attention because it has some actions related to neurogenesis ...
Yoshida, Akira, Ueda, Hiroshi
openaire   +3 more sources

Gintonin facilitates brain delivery of donepezil, a therapeutic drug for Alzheimer disease, through lysophosphatidic acid 1/3 and vascular endothelial growth factor receptors

Journal of Ginseng Research, 2021
Background: Gintonin is a ginseng-derived exogenous G-protein–coupled lysophosphatidic acid (LPA) receptor ligand, which exhibits in vitro and in vivo functions against Alzheimer disease (AD) through lysophosphatidic acid 1/3 receptors.
Sun-Hye Choi, Na-Eun Lee, Hee-Jung Cho, Ra Mi Lee, Hyewhon Rhim, Hyoung-Chun Kim, Mun Han, Eun-Hee Lee, Juyoung Park, Seung-Yeol Nah   +9 more
doaj   +1 more source

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Siedler, F., Sellmayer, Alois, Gopfert, M. S., Siess, W.   +3 more
core   +1 more source

The PDZ protein GIPC regulates trafficking of the LPA1 receptor from APPL signaling endosomes and attenuates the cell's response to LPA. [PDF]

PLoS ONE, 2012
Lysophosphatidic acid (LPA) mediates diverse cellular responses through the activation of at least six LPA receptors--LPA(1-6,) but the interacting proteins and signaling pathways that mediate the specificity of these receptors are largely unknown.
Tal Varsano, Vanessa Taupin, Lixia Guo, Oscar Y Baterina, Marilyn G Farquhar   +4 more
doaj   +1 more source

The LPA-CDK5-tau pathway mediates neuronal injury in an in vitro model of ischemia-reperfusion insult

BMC Neurology, 2022
Lysophosphatidic acid (LPA) is a common glycerol phospholipid and an important extracellular signaling molecule. LPA binds to its receptors and mediates a variety of biological effects, including the pathophysiological process underlying ischemic brain ...
Yaya Wang, Jie Zhang, Liqin Huang, Yanhong Mo, Changyu Wang, Yiyi Li, Yangyang Zhang, Zhaohui Zhang   +7 more
doaj   +1 more source

A requirement for membrane cholesterol in the  -arrestin- and clathrin-dependent endocytosis of LPA1 lysophosphatidic acid receptors [PDF]

, 2005
Lysophosphatidic acid (LPA) stimulates heterotrimeric G protein signaling by activating three closely related receptors, termed ...
Trejo, Jo Ann, Radhakrishna, Harish, Jones, Kymry T., Urs, Nikhil M., Severin, Jamie E., Salo, Paul D.   +5 more
core   +1 more source

Lysophospholipid receptors in vertebrate development, physiology, and pathology

Journal of Lipid Research, 2009
Lysophospholipid (LP) research has experienced a period of renaissance with the discovery of the lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) receptors in the late 1990s.
Athanasia Skoura, Timothy Hla
doaj   +1 more source