LPA5 is abundantly expressed by human mast cells and important for lysophosphatidic acid induced MIP-1β release. [PDF]
PLoS ONE, 2011 Lysophosphatidic acid (LPA) is a bioactive lipid inducing proliferation, differentiation as well as cytokine release by mast cells through G-protein coupled receptors. Recently GPR92/LPA5 was identified as an LPA receptor highly expressed by cells of the
Anders Lundequist, Joshua A Boyce
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Role of lysophosphatidic acid and its receptors in health and disease: novel therapeutic strategies
Signal Transduction and Targeted Therapy, 2021 Lysophosphatidic acid (LPA) is an abundant bioactive phospholipid, with multiple functions both in development and in pathological conditions. Here, we review the literature about the differential signaling of LPA through its specific receptors, which ...
Luiz Henrique Medeiros Geraldo +8 more
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Phosphorylation and desensitization of the lysophosphatidic acid receptor LPA1 [PDF]
Biochemical Journal, 2005 In C9 cells, LPA (lysophosphatidic acid) induced inositol phosphate production, increased intracellular calcium concentration and inhibited adenylate cyclase activity. These responses were abolished in cells challenged with active phorbol esters. Action of phorbol esters was blocked by inhibitors of PKC (protein kinase C) and by its down-regulation ...
S Eréndira, Avendaño-Vázquez +2 more
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Ginseng Gintonin Contains Ligands for GPR40 and GPR55
Molecules, 2020 Gintonin, a novel ginseng-derived glycolipoprotein complex, has an exogenous ligand for lysophosphatidic acid (LPA) receptors. However, recent lipid analysis of gintonin has shown that gintonin also contains other bioactive lipids besides LPAs, including
Yeon-Jin Cho +9 more
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Lateral access mechanism of LPA receptor probed by molecular dynamics simulation.
PLoS ONE, 2022 G-protein-coupled receptors (GPCR) are a family of membrane receptors that play important roles in the regulation of various physiological phenomena. LPA receptors (LPA1-6) are members of the class A GPCRs, which transduce a lysophosphatidic acid (LPA ...
Rieko Suenaga +4 more
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Lysophosphatidic Acid Induces Erythropoiesis through Activating Lysophosphatidic Acid Receptor 3
Stem Cells, 2011 AbstractLysophosphatidic acid (LPA), an extracellular lipid mediator, exerts multiple bioactivities through activating G protein-coupled receptors. LPA receptor 3 (LPA3) is a member of the endothelial differentiation gene family, which regulates differentiation and development of the circulation system. However, the relationship among the LPA receptors
Chiang, Chi-Ling +8 more
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Angiogenic effect of lysophosphatidic acid receptors on cervical cancer cells
, 2017 Cervical cancer was recently reported to be the fourth leading cause of cancer death in women worldwide, causing an estimated 265,700 deaths a year.
Chen, Ruey-Jien;Chou, Chia-Hung;Chen, Shee-Uan;Lee, Hsinyu +1 more
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, 2019 Lysophosphatidic acid (LPA) is a collective name for a set of bioactive lipid species. Via six widely distributed G protein-coupled receptors (GPCRs), LPA elicits a plethora of biological responses, contributing to inflammation, thrombosis and ...
Kamato, Danielle +4 more
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Lysophosphatidic acid LPA1-3 receptors: signaling, regulation and in silico analysis of their putative phosphorylation sites [PDF]
, 2014 Lysophosphatidic acid (LPA) is a bioactive lipid with a plethora of roles in the normal function of our organism as well as in the pathogenesis of many diseases.
Aurelio Hernández-Méndez, Rocío Alcántara-Hernández, J. Adolfo García-Sáinz
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Lysophosphatidic acid and itsreceptors: Role in bronchial asthma pathogenesis
Acta Biomedica ScientificaLysophosphatidic acid (LPA) is a biologically active lipid mediator that regulates a number ofsignaling pathways involved in the pathogenesis of bronchial asthma.
O. Yu. Kytikova +2 more
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