Results 71 to 80 of about 24,225 (232)
, 2018 Background: The spread of tumors through neural routes is common in several types of cancer in which patients suffer from a moderate-to-severe neuropathy, neural damage and a distorted quality of life.
Elsadek, Bakheet, Maqboul, Ahmad
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The Role of Lysophosphatidic Acid in Neuropsychiatric and Neurodegenerative Disorders
Future PharmacologyIndividuals suffering from diverse neuropsychiatric and neurodegenerative disorders often have comparable symptoms, which may underline the implication of shared hereditary influences and the same biological processes.
Simona Dedoni +5 more
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Autotaxin-Lysophosphatidic Acid: From Inflammation to Cancer Development
Mediators of Inflammation, 2017 Lysophosphatidic acid (LPA) is a ubiquitous lysophospholipid and one of the main membrane-derived lipid signaling molecules. LPA acts as an autocrine/paracrine messenger through at least six G protein-coupled receptors (GPCRs), known as LPA1–6, to induce
Silvia Anahi Valdés-Rives +1 more
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Frontiers in Endocrinology, 2022 Until now, the molecular mechanisms underlining sperm motility defect causing male infertility are still poorly understood. Safe and effective compounds or drugs that can improve sperm motility are also very limited.
Yinlam Li +14 more
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Ferroptosis: The Demise of Cells Through Phospholipid Peroxidation
Advanced Science, EarlyView.The relative abundance of peroxidation‐resistant monounsaturated fatty acids (MUFAs) vs. peroxidation‐sensitive polyunsaturated fatty acids (PUFAs) incorporated into phospholipid (PL) is a key determinant of ferroptosis sensitivity, as the peroxidation of PL PUFA acyl chains (PUFA‐PL) disrupts membrane integrity, causing ferroptotic cell death ...
Shaojie Cui, Jin Ye
wiley +1 more source
Sphingosine 1-phosphate receptors: do they have a therapeutic potential in cardiac fibrosis? [PDF]
, 2017 Sphingosine 1-phosphate (S1P) is a bioactive lipid that is characterized by a peculiar mechanism of action. In fact, S1P, which is produced inside the cell, can act as an intracellular mediator, whereas after its export outside the cell, it can act as ...
Frati, Alessia +4 more
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Lysophosphatidic acid (LPA) receptors: Signaling properties and disease relevance [PDF]
Prostaglandins & Other Lipid Mediators, 2010 Lysophosphatidic acid (LPA), a water-soluble phospholipid, has gained significant attention in recent years since the discovery that it acts as a potent signaling molecule with wide-ranging effects on many different target tissues. There are currently five identified G protein-coupled receptors for LPA and more are undergoing validation. The complexity
Mu-En, Lin, Deron R, Herr, Jerold, Chun
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Eye and Brain, 2010 Eric Birgbauer, Jerold ChunDepartment of Molecular Biology, Helen L Dorris Institute for Neurological and Psychiatric Disorders, The Scripps Research Institute, La Jolla, CA, USA Abstract: One of the major requirements in the development of the visual ...
Eric Birgbauer, Jerold Chun
doaj
Lysophosphatidic Acid (LPA) Induces Plasma Exudation and Histamine Release in Mice via LPA Receptors
Journal of Pharmacological Sciences, 2006 .: Lysophosphatidic acid (LPA), the simplest of the water-soluble phospholipids, can evoke various biological responses. The present study examined the activity of LPA to induce plasma exudation and histamine release in mice.
Terumasa Hashimoto +2 more
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Lipids in Health and Disease, 2021 Background Lysophosphatidic acid (LPA) is a bioactive lysophospholipid that acts through its six cognate G protein-coupled receptors. As a family, lysophospholipids have already produced medicines (e.g., sphingosine 1-phosphate) as is being pursued for ...
Manisha Ray +3 more
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