Results 101 to 110 of about 6,064 (188)

Structural identification of oxidized acyl-phosphatidylcholines that induce platelet activation [PDF]

, 2005
Oxidation of low-density lipoprotein (LDL) generates proinflammatory and prothrombotic mediators that may play a crucial role in cardiovascular and inflammatory diseases.
Berliner JA, Bittman R, Casals-Stenzal J, Esterbauer H, Fernandez-Ortiz A, Frey B, Goetzl EJ, Holvoet P, Itabe H, Kamido H, Kamido H, Kern H, Kinsella BT, Kitagawa S, O'Flaherty JT, O'Flaherty JT, Rasmussen UB, Sevanian A, Subbanagounder G, Tanaka T, Trip MD, Volf I, Watson AD, Weidtmann A   +23 more
core   +1 more source

Primary human endothelial cells secrete agents that reduce responsiveness to lysophosphatidic acid (LPA) [PDF]

, 2012
The plasma level of LPA (lysophosphatidic acid) (200–600 nM) is well within the range that promotes proliferation and migration of vascular ECs (endothelial cells), yet vessels are quiescent and stable.
Kazlauskas, Andrius, Park, Eun Young
core   +3 more sources

Daily rhythms of glycerophospholipid synthesis in fibroblast cultures involve differential enzyme contributions [PDF]

, 2013
Circadian clocks regulate the temporal organization of several biochemical processes including lipid metabolism and their disruption leads to severe metabolic disorders. Immortalized cell lines acting as circadian clocks display daily variations in [32P]-
Acosta Rodríguez, Victoria América, Garbarino Pico, Eduardo, Giusto, Norma Maria, Gorne, Lucas Damián, Guido, Mario Eduardo, Marquez, Sebastian, Pasquaré, Susana Juana, Salvador, Gabriela Alejandra   +7 more
core   +2 more sources

Identification of a novel class of autotaxin inhibitors through cross-screening [PDF]

, 2015
Three novel series were generated in order to mimic the pharmacophoric features displayed by lead compound AM095, a Lysophosphatidic acid (LPA1) receptor antagonist. Biological evaluation of this array of putative LPA1 antagonists led us to the discovery
Budd, David C., Castagna, Diana, Duffy, Emma L., Jamieson, Craig, Macdonald, Simon J. F., Pritchard, John M., Semaan, Dima, Watson, Allan J. B., Young, Louise C.   +8 more
core   +1 more source

CXCL12/SDF-1 from perisynaptic Schwann cells promotes regeneration of injured motor axonterminals [PDF]

, 2017
The neuromuscular junction has retained through evolution the capacity to regenerate after damage, but little is known on the inter-cellular signals involved in its functional recovery from trauma, autoimmune attacks, or neurotoxins.
Aram Megighian, Bagri A, Cesare Montecucco, Chiara M Mazzanti, Egle Radice, Elisa Duregotti, Elisanna Bergamin, Francesca Lessi, Guyon A, Marco La Ferla, Marco Pirazzini, Marcus Thelen, Michela Rigoni, Michele Menicagli, Paolo Aretini, Samuele Negro, Sara Franceschi, Shellard A   +17 more
core   +1 more source

Fingolimod for the treatment of neurological diseases—state of play and future perspectives [PDF]

, 2014
Sphingolipids are a fascinating class of signaling molecules derived from the membrane lipid sphingomyelin. They show abundant expression in the brain.
Rajkumar Vutukuri, Robert Brunkhorst, Waltraud Pfeilschifter   +2 more
core   +2 more sources

Lysophospholipid (S1P) receptors in GtoPdb v.2025.3

IUPHAR/BPS Guide to Pharmacology CITE
Sphingosine 1-phosphate (S1P) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid receptors [98]) are activated by the endogenous lipid sphingosine 1-phosphate (S1P). Originally cloned as orphan members of the endothelial differentiation gene (edg) family [16, 125], the receptors are currently designated as S1P1R ...
Victoria Blaho, Jerold Chun, Deron R. Herr, Danielle Jones, Yasuyuki Kihara   +4 more
openaire   +1 more source

Orthopedic Center of Chinese PLA, Urumqi General Hospital of Lanzhou Military Region, [PDF]

Sphingosine-1-phosphate is a possible fibrogenic factor in ...
Chenguang Zhao, Jie Qin, Wei Lei, Xijing He, Yong Jia, Yucheng Guan   +5 more
core  

Focus on LPA signaling: a promising therapeutic target to foster regeneration in immune-mediated neuropathies. [PDF]

Neural Regen Res, 2023
Szepanowski F, Stettner M.
europepmc   +1 more source

Lysophospholipid (LPA) receptors in GtoPdb v.2025.3

IUPHAR/BPS Guide to Pharmacology CITE
Lysophosphatidic acid (LPA) receptors (nomenclature as agreed by the NC-IUPHAR Subcommittee on Lysophospholipid Receptors [67, 27, 96, 151]) are activated by the endogenous phospholipid LPA. The first receptor, LPA1, was identified as ventricular zone gene-1 (vzg-1) [52], This discovery represented the beginning of the de-orphanisation of members of ...
Victoria Blaho, Jerold Chun, Deron R. Herr, Yasuyuki Kihara, Tony Ngo, Valerie P. Tan   +5 more
openaire   +1 more source