Results 121 to 130 of about 2,946 (161)

Lysophospholipid Receptors: Signaling and Biology

Annual Review of Biochemistry, 2004
▪ Abstract  Lysophospholipids (LPs), such as lysophosphatidic acid and sphingosine 1-phosphate, are membrane-derived bioactive lipid mediators. LPs can affect fundamental cellular functions, which include proliferation, differentiation, survival, migration, adhesion, invasion, and morphogenesis.
Isao, Ishii, Nobuyuki, Fukushima, Xiaoqin, Ye, Jerold, Chun   +3 more
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Lysophospholipid receptors in cell signaling

Biochemistry (Moscow), 2007
There is increasing evidence that different phospholipids are involved in regulation of various cell processes and cell-cell interactions. Lysophospholipids (lysophosphatidic acid, lysophosphatidylcholine) and a number of lysosphingolipids play particular roles in these regulations. Their effects are mediated by specific G-protein-coupled receptors.
T I, Torkhovskaya, O M, Ipatova, T S, Zakharova, M M, Kochetova, E M, Khalilov   +4 more
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GPR55 and GPR35 and their relationship to cannabinoid and lysophospholipid receptors

Life Sciences, 2013
This review presents a summary of what is known about the G-protein coupled receptors GPR35 and GPR55 and their potential characterization as lysophospholipid or cannabinoid receptors, respectively. Both GPR35 and GPR55 have been implicated as important targets in pain and cancer, and additional diseases as well.
Mary Abood, Pingwei Zhao
exaly   +3 more sources

Cell surface receptors in lysophospholipid signaling

Seminars in Cell & Developmental Biology, 2004
The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), regulate various signaling pathways within cells by binding to multiple G protein-coupled receptors. Receptor-mediated LPA and S1P signaling induces diverse cellular responses including proliferation, adhesion, migration, morphogenesis, differentiation and survival ...
Brigitte, Anliker, Jerold, Chun
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Roles for lysophospholipid S1P receptors in multiple sclerosis

Critical Reviews in Biochemistry and Molecular Biology, 2010
Sphingosine 1-phosphate (S1P) signaling in the treatment of multiple sclerosis (MS) has been highlighted by the efficacy of FTY720 (fingolimod), which upon phosphorylation can modulate S1P receptor activities. FTY720 has become the first oral treatment for relapsing MS that was approved by the FDA in September 2010. Phosphorylated FTY720 modulates four
Kyoko, Noguchi, Jerold, Chun
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Chemical approaches to the lysophospholipid receptors

Prostaglandins & Other Lipid Mediators, 2005
Both ligand-based and GPCR privileged scaffold chemical tools have recently emerged to provide new insights into the function and physiology of the GPCR lysophospholipid receptors both in vitro and in vivo. Both rational, design-based approaches as well as hybrid approaches where high throughput screening has been coupled to an understanding of ...
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Neurobiology of Receptor‐Mediated Lysophospholipid Signaling: From the First Lysophospholipid Receptor to Roles in Nervous System Function and Development

Annals of the New York Academy of Sciences, 2000
Abstract: Identification of the first lysophospholipid receptor, LPA1/Vzg‐1, cloned by way of neurobiological analyses on the embryonic cerebral cortex, has led to the realization and demonstration that there exist multiple, homologous LP receptors, including those encoded by a number of orphan receptor genes known as “Edg,” all of which are members ...
J, Chun, J A, Weiner, N, Fukushima, J J, Contos, G, Zhang, Y, Kimura, A, Dubin, I, Ishii, J H, Hecht, C, Akita, D, Kaushal   +10 more
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International Union of Pharmacology. XXXIV. Lysophospholipid Receptor Nomenclature

Pharmacological Reviews, 2002
The lysophospholipids, lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P), are now recognized as important extracellular signaling molecules. These lipid mediators are pleiotropic; among the most common cellular responses are mitogenesis, cell survival (anti-apoptosis), inhibition of adenylyl cyclase and calcium mobilization.
Chun, Jerold, Goetzl, Edward J, Hla, Timothy, Igarashi, Yasuyuki, Lynch, Kevin R, Moolenaar, Wouter, Pyne, Susan, Tigyi, Gabor   +7 more
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Lysophospholipid Receptors: Implications for Neural Signaling

Critical Reviews in Neurobiology, 1999
Lysophospholipids (LPs) such as lysophosphatidic acid (LPA) and sphingosine-1-phosphate (S1P) represent quantitatively minor phospholipid species that nonetheless are capable of acting as extracellular signals. As an organ system dominated by lipids, the nervous system would seem a likely benefactor of this form of intercellular signaling.
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Microglial activation state and lysophospholipid acid receptor expression

International Journal of Developmental Neuroscience, 2003
AbstractWe used a simple commercial magnetic immunobead method for the preparation of acutely isolated microglial cells from postnatal days 1–3 rat brain. With the exception of a 15 min enzyme incubation, all stages are carried out at 4 °C, minimizing the opportunity for changes in gene expression during the isolation to be reflected in changes in ...
Chui-Se, Tham, Fen-Fen, Lin, Tadimeti S, Rao, Naichen, Yu, Michael, Webb   +4 more
openaire   +2 more sources