Results 131 to 140 of about 2,946 (161)

Long-lasting enhancement of ACh receptor currents by lysophospholipids

Molecular Brain Research, 1997
Lysophosphatidylcholine (LysoPtdCho) and lysophosphatidylethanolamine (LysoPtdEtn), which are formed by phospholipase A2-catalyzed hydrolysis of phosphatidylcholine (PtdCho) and phosphatidylethanolamine (PtdEtn), respectively, are proposed to be involved in protein kinase C (PKC) activation.
Y, Ikeuchi, T, Nishizaki, T, Matsuoka, K, Sumikawa   +3 more
openaire   +2 more sources

Lysophospholipid receptor‐dependent and ‐independent calcium signaling

Journal of Cellular Biochemistry, 2004
AbstractChanges in cellular Ca2+ concentrations form a ubiquitous signal regulating numerous processes such as fertilization, differentiation, proliferation, contraction, and secretion. The Ca2+ signal, highly organized in space and time, is generated by the cellular Ca2+ signaling toolkit.
openaire   +2 more sources

Lysophospholipid Activation of G Protein-Coupled Receptors

2008
One of the major lipid biology discoveries in last decade was the broad range of physiological activities of lysophospholipids that have been attributed to the actions of lysophospholipid receptors. The most well characterized lysophospholipids are lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P). Documented cellular effects of these lipid
Tetsuji, Mutoh, Jerold, Chun
openaire   +2 more sources

Lysophospholipids and their G protein-coupled receptors in inflammation and immunity

Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids, 2002
Among the family of lipid-derived mediators, the group of lysophospholipids including lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have growth-related and -unrelated effects on diverse cell types including lymphocytes, macrophages, smooth muscle cells, endothelial cells, and neuronal cells.
Markus H, Gräler, Edward J, Goetzl
openaire   +2 more sources

Bioactive Lysophospholipids and Their G Protein-Coupled Receptors

Experimental Cell Research, 1999
Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are serum-borne lysophospholipids that signal through their cognate G protein-coupled receptors to evoke a great variety of responses in numerous cell types. In addition to stimulating cell proliferation and survival, LPA and S1P induce profound cytoskeletal changes through Rho-mediated ...
openaire   +2 more sources

Lysophospholipid Mediators: Their Receptors and Synthetic Pathways

2015
It is now widely accepted that lysophospholipids (LPLs), a product of the phospholipase A reaction, function as mediators through G protein-coupled receptors (GPCRs). Notably, recent studies of lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) have revealed their essential roles in vivo.
Kuniyuki Kano, Kumiko Makide, Jun Ishiguro, Hiroshi Yukiura, Shizu Aikawa, Akiharu Uwamizu, Yuji Shinjo, Kahori Namiki, Hiroki Kawana, Saki Nemoto, Hirotaka Matsumoto, Ryoji Kise, Asuka Inoue, Junken Aoki   +13 more
openaire   +1 more source

Phospholipids | Lysophospholipid Receptors

2021
Sue C. Lee, Mélanie A. Dacheux, Gábor J. Tigyi   +2 more
openaire   +1 more source

Lysophospholipid Receptors and Effects in Breast Cancer

2000
Abstract : Lysophosphatidic acid (LPA) and sphingosine 1-phosphate (S1P) are widely-distributed stimuli of cellular growth and functions, which are generated enzymatically from precursors in membranes of activated normal cells and at much higher levels from many types of cancers.
openaire   +1 more source

Critical Roles of Lysophospholipid Receptors in Activation of Neuroglia and Their Neuroinflammatory Responses

International Journal of Molecular Sciences, 2021
Bhakta Prasad Gaire, Gaire Bhakta Prasad
exaly  

Role of Lysophospholipid Metabolism in Chronic Myelogenous Leukemia Stem Cells

Cancers, 2021
Kazuhito Naka, Naka Kazuhito
exaly