Results 201 to 210 of about 81,074 (260)
Some of the next articles are maybe not open access.
Dynamics and modulation of metabotropic glutamate receptors
Current Opinion in Pharmacology, 2015The metabotropic glutamate receptors (mGluRs) are glutamate-activated G protein-coupled receptors widely expressed in the central nervous system. The eight mGluRs subtypes modulate transmission at many synapses, and are interesting therapeutic targets for the treatment of many neurological and psychiatric diseases.
Jean-Philippe Pin +3 more
openaire +5 more sources
The metabotropic glutamate receptors: Structure and functions
Neuropharmacology, 1995Glutamate is the main excitatory neurotransmitter in the brain. For many years it has been considered to act only on ligand-gated receptor channels--termed NMDA, AMPA and kainate receptors--involved in the fast excitatory synaptic transmission. Recently, glutamate has been shown to regulate ion channels and enzymes producing second messengers via ...
Jean-Philippe Pin, Robert M. Duvoisin
openaire +3 more sources
Metabotropic glutamate receptors
Cell and Tissue Research, 2006Metabotropic glutamate receptors (mGlus) are a family of G-protein-coupled receptors activated by the neurotransmitter glutamate. Molecular cloning has revealed eight different subtypes (mGlu1-8) with distinct molecular and pharmacological properties. Multiplicity in this receptor family is further generated through alternative splicing. mGlus activate
Ferraguti F., Shigemoto R.
openaire +3 more sources
Metabotropic glutamate receptors
Amino Acids, 2007l-Glutamate, one of the main neurotransmitters in the central nervous system (CNS), acts on two groups of receptors: (a) a group of ionotropic receptors that includes N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methylisoxazole-4-propionate (AMPA), and kainate receptors, and (2) a group of metabotropic receptors (mGluRs).
Andrzej Pilc, Krystyna Ossowska
openaire +2 more sources
Structure of the metabotropic glutamate receptor
Current Opinion in Neurobiology, 2003In the twelve years since the molecular elucidation of the metabotropic glutamate receptor subtype 1, a class III family of G-protein-coupled receptors has emerged; members of this family include the calcium-sensing receptor, the GABA(B) receptor, some odorant receptors and some taste receptors.
Shigetada Nakanishi +2 more
openaire +2 more sources
Metabotropic Glutamate Receptors and Neurodegeneration
2004Metabotropic glutamate (mGlu) receptors, which exert a modulatory effect on excitatory synaptic transmission, are considered as potential targets for neuroprotective drugs and the advent of potent and centrally available subtype-selective ligands has lead to an extensive investigation of the role of individual mGlu receptor subtypes in ...
BRUNO, Valeria Maria Gloria +7 more
openaire +6 more sources
A family of metabotropic glutamate receptors
Neuron, 1992Three cDNA clones, mGluR2, mGluR3, and mGluR4, were isolated from a rat brain cDNA library by cross-hybridization with the cDNA for a metabotropic glutamate receptor (mGluR1). The cloned receptors show considerable sequence similarity with mGluR1 and possess a large extracellular domain preceding the seven putative membrane-spanning segments. mGluR2 is
Yasuto Tanabe +4 more
openaire +3 more sources
Metabotropic glutamate receptors and epilepsy
Journal of the Neurological Sciences, 2006Metabotropic glutamate receptors (mGluRs) play an important role in the initiation of ictal discharges by participating in the interictal-ictal transition, and may play a crucial role in recruiting normal brain tissue into synchronized discharges, thereby facilitating propagation of seizure activity.
Michel Baudry +2 more
openaire +3 more sources
Metabotropic Glutamate Receptors in Glial Cells
Neurochemical Research, 2008Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and exerts its actions via a number of ionotropic glutamate receptors/channels and metabotropic glutamate (mGlu) receptors. In addition to being expressed in neurons, glutamate receptors are expressed in different types of glial cells including astrocytes ...
Simona D'Antoni +6 more
openaire +6 more sources
Metabotropic Glutamate Receptors as Drug Targets
Current Drug Targets, 2007L-glutamate (Glu), the main excitatory amino acid neurotransmitter in the mammalian central nervous system, is involved in many physiological functions, including learning and memory, but also in toxic phenomena occurring in numerous degenerative or neurological diseases.
Récasens, Max +4 more
openaire +4 more sources