Results 61 to 70 of about 112,349 (256)

Permissive role for mGlu1 metabotropic glutamate receptors in excitotoxic retinal degeneration [PDF]

, 2017
Neuroprotection is an unmet need in eye disorders characterized by retinal ganglion cell (RGC) death, such as prematurity-induced retinal degeneration, glaucoma, and age-related macular degeneration.
Battaglia, Giuseppe, Beneventano, Martina, Bruno, Valeria, Bucci, Domenico, Di Pietro, Paola, Liberatore, Francesca, Madonna, Michele, Mascio, Giada, Nicoletti, Ferdinando, Puliti, Alda Maria, Romano, Maria Rosaria   +10 more
core   +1 more source

Uncovering the Lipid Interface in Neurotransmission: Single Molecule Measurements of Neurotransmitters Interacting with Membranes Reveal Species Dependent Membrane Binding

Advanced Science, EarlyView.
Using single‐molecule whispering gallery mode sensors, neurotransmitter‐specific membrane binding signatures are measured that reveal intrinsically distinct interaction kinetics and orientations on a lipid membrane. Abstract Neurotransmitters (NTs) have traditionally been understood to act via aqueous‐phase receptor binding, but growing evidence ...
Thomas L. Derrien, Aneeth Kakkanattu Arunkumar, Rosalind Cross, Emilie Sunnucks, Frank Vollmer   +4 more
wiley   +1 more source

Long-Term Depression of Striatal DA Release Induced by mGluRs via Sustained Hyperactivity of Local Cholinergic Interneurons

Frontiers in Cellular Neuroscience, 2021
The cellular mechanisms regulating dopamine (DA) release in the striatum have attracted much interest in recent years. By in vitro amperometric recordings in mouse striatal slices, we show that a brief (5 min) exposure to the metabotropic glutamate ...
Nicola B. Mercuri, Nicola B. Mercuri, Mauro Federici, Francesca Romana Rizzo, Lorenzo Maugeri, Sebastian L. D’Addario, Sebastian L. D’Addario, Sebastian L. D’Addario, Rossella Ventura, Rossella Ventura, Nicola Berretta   +10 more
doaj   +1 more source

Xanthurenic Acid Activates mGlu2/3 Metabotropic Glutamate Receptors and is a Potential Trait Marker for Schizophrenia

Scientific Reports, 2015
The kynurenine pathway of tryptophan metabolism has been implicated in the pathophysiology of psychiatric disorders, including schizophrenia. We report here that the kynurenine metabolite, xanturenic acid (XA), interacts with and activates mGlu2 and ...
F. Fazio, L. Lionetto, M. Curto, L. Iacovelli, Michele Cavallari, C. Zappulla, M. Ulivieri, Flavia Napoletano, M. Capi, V. Corigliano, S. Scaccianoce, A. Caruso, J. Miele, A. De Fusco, Luisa Di Menna, A. Comparelli, A. de Carolis, R. Gradini, R. Nisticò, A. de Blasi, P. Girardi, V. Bruno, G. Battaglia, F. Nicoletti, M. Simmaco   +24 more
semanticscholar   +1 more source

Antibody‐Empowered Nanomedicine for Precise Biomedical Applications

Advanced Science, EarlyView.
This review explores strategies for functionalizing nanoparticles with antibodies to construct antibody‐empowered nanomedicine. It discusses the classification of these nanomedicines based on antibody structure, with a specific focus on their biomedical applications in diagnostics, bioimaging, and therapeutics for various diseases.
Chen Chen, Xinglin Chen, Zhenhao Gao, Meng Sun, Yaozong Yu, Fang Lv, Qiujun Wang, Jinfeng Zhang   +7 more
wiley   +1 more source

Deletion of Metabotropic Glutamate Receptors 2 and 3 (mGlu2 & mGlu3) in Mice Disrupts Sleep and Wheel-Running Activity, and Increases the Sensitivity of the Circadian System to Light.

PLoS ONE, 2015
Sleep and/or circadian rhythm disruption (SCRD) is seen in up to 80% of schizophrenia patients. The co-morbidity of schizophrenia and SCRD may in part stem from dysfunction in common brain mechanisms, which include the glutamate system, and in particular,
David Pritchett, Aarti Jagannath, Laurence A Brown, Shu K E Tam, Sibah Hasan, Silvia Gatti, Paul J Harrison, David M Bannerman, Russell G Foster, Stuart N Peirson   +9 more
doaj   +1 more source

Glutamatergic system components as potential biomarkers and therapeutic targets in cancer in non-neural organs

Frontiers in Endocrinology, 2022
Glutamate is one of the most abundant amino acids in the blood. Besides its role as a neurotransmitter in the brain, it is a key substrate in several metabolic pathways and a primary messenger that acts through its receptors outside the central nervous ...
Ana Cristina García-Gaytán, Andy Hernández-Abrego, Mauricio Díaz-Muñoz, Isabel Méndez   +3 more
doaj   +1 more source

Selective Negative Allosteric Modulation Of Metabotropic Glutamate Receptors – A Structural Perspective of Ligands and Mutants

Scientific Reports, 2015
The metabotropic glutamate receptors have a wide range of modulatory functions in the central nervous system. They are among the most highly pursued drug targets, with relevance for several neurological diseases and a number of allosteric modulators have
K. Harpsøe, Vignir Ísberg, B. Tehan, Dahlia R. Weiss, Angela Arsova, F. Marshall, H. Bräuner‐Osborne, David E. Gloriam   +7 more
semanticscholar   +1 more source

Metabotropic Glutamate Receptor Activation in Cerebelar Purkinje Cells as Substrate for Adaptive Timing of the Classicaly Conditioned Eye Blink Response [PDF]

, 1995
To understand how the cerebellum adaptively times the classically conditioned nictitating membrane response (NMR), a model of the metabotropic glutamate receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.
Bullock, Daniel, Fiala, John C., Grossberg, Stephen   +2 more
core   +1 more source

Decoding the Pathophysiology of Autoimmune Diseases—Mechanism, Triggers, and Nanotherapeutics: A Review

Advanced NanoBiomed Research, EarlyView.
This review highlights how autoimmune diseases arise from intertwined immunological, genetic, and environmental factors, emphasizing gut microbiota dysbiosis as a pivotal driver. It outlines emerging nanotechnology‐based strategies—such as liposomes, hydrogels, and polymeric nanoparticles—that enhance targeted drug delivery, minimize systemic toxicity,
Md. Meraj Ansari, Yunhui Min, Eun‐Ju Ko, Doyoung Kwon, Rehan Khan, Young‐Ok Son   +5 more
wiley   +1 more source