Results 81 to 90 of about 53,335 (249)

Oxygen/Glucose deprivation induces a reduction in synaptic AMPA receptors on hippocampal CA3 neurons mediated by mGluR1 and adenosine A3 receptors [PDF]

, 2011
Hippocampal CA1 pyramidal neurons are highly sensitive to ischemic damage, whereas neighboring CA3 pyramidal neurons are less susceptible. It is proposed that switching of AMPA receptor (AMPAR) subunits on CA1 neurons during an in vitro model of ischemia,
Cimarosti, Helena, Dennis, Siobhan, Hanley, Jonathan G., Henley, Jeremy M., Jaafari, Nadia, Mellor, Jack R.   +5 more
core   +1 more source

Activation requirements for metabotropic glutamate receptors [PDF]

Neuroscience Letters, 2013
It has been common experimentally to use high frequency, tetanic, stimulation to activate metabotropic glutamate receptors (mGluRs) in cortex and thalamus. To determine what type of stimulation is actually necessary to activate mGluRs we examined the effects of varying stimulation duration and intensity on activating mGluR responses.
S. Murray Sherman, Angela N. Viaene, Iraklis Petrof   +2 more
openaire   +3 more sources

Recent Developments in the Optical Control of Adrenergic Signaling

Medicinal Research Reviews, EarlyView.
ABSTRACT Adrenoceptors (ARs) play a vital role in various physiological processes and are key therapeutic targets. The advent of optical control techniques, including optogenetics and photopharmacology, offers the potential to modulate AR signaling with precise temporal and spatial resolution. In this review, we summarize the latest advancements in the
Shuang Shi, Yangzhi Cao, Maikel Wijtmans, Henry F. Vischer, Rob Leurs   +4 more
wiley   +1 more source

Metabotropic Glutamate Receptor Activation in Cerebelar Purkinje Cells as Substrate for Adaptive Timing of the Classicaly Conditioned Eye Blink Response [PDF]

, 1995
To understand how the cerebellum adaptively times the classically conditioned nictitating membrane response (NMR), a model of the metabotropic glutamate receptor (mGluR) second messenger system in cerebellar Purkinje cells is constructed.
Bullock, Daniel, Fiala, John C., Grossberg, Stephen   +2 more
core   +1 more source

The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]

, 2017
The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro, Castellani, Angela, Giacomello, Marta, Lim, Dmitry, Mario, Agnese De, Massimino, Maria Lina, Peggion, Caterina, Sorgato, Maria Catia, Viviani, Francesca   +8 more
core   +1 more source

A comprehensive review on adaptive plasticity and recovery mechanisms post‐acquired brain injury

Neuroprotection, EarlyView.
This figure illustrates the dynamic process of neurogenesis following brain injury, focusing on the roles of neural stem and progenitor cells at the injury site. Key mechanisms include axonal sprouting, synaptogenesis, dendritic remodeling, and brain‐derived neurotrophic factor signaling via TrkB receptors.
Ravi Kumar Rajan
wiley   +1 more source

Memantine Administration Enhances Glutamatergic and GABAergic Pathways in the Human Hippocampus of Alzheimer's Disease Patients

PROTEOMICS, EarlyView.
ABSTRACT One of the traditional treatments in Alzheimer's disease (AD) is administration of memantine, the NMDA receptor antagonist. However, the molecular mechanism of the complex memantine action and the impact on the hippocampal proteome in humans is unknown.
Ivo Fabrik, Rudolf Kupcik, Daniela Fabrikova, Marketa Chvojkova, Kristina Holubova, Kristina Hakenova, Martin Horak, Jiri Soukup, Monika Manethova, Robert Rusina, Radoslav Matej, Ales Ryska, Ondrej Soukup   +12 more
wiley   +1 more source

Role of Metabotropic Glutamate Receptors in Neurological Disorders

Frontiers in Molecular Neuroscience, 2019
Glutamate is a fundamental excitatory neurotransmitter in the mammalian central nervous system (CNS), playing key roles in memory, neuronal development, and synaptic plasticity.
Rosalia Crupi, Daniela Impellizzeri, Salvatore Cuzzocrea, Salvatore Cuzzocrea   +3 more
doaj   +1 more source

Changes in synaptic transmission and protein expression in the brains of adult offspring after prenatal inhibition of the kynurenine pathway [PDF]

, 2013
During early brain development, N-methyl-d-aspartate (NMDA) receptors are involved in cell migration, neuritogenesis, axon guidance and synapse formation, but the mechanisms which regulate NMDA receptor density and function remain unclear. The kynurenine
Ahn, Al-Hayani, Alberati-Giani, Alexander, Alexander, Alvarez, Angot, Baez, Banerjee, Beal, Breton, Broadstock, Brown, Brown, C.M. Forrest, Cai, Charytoniuk, Chess, Chess, Chess, Chiarugi, Clark, Colonnese, Copeland, Corbo, Couillard-Despres, Cozzi, Cuppini, D. Jerusalinsky, Dave, Dellovade, Dikranian, Dobbing, Dobelis, Drian, du Bois, Dykens, E. Kornisiuk, English, Erhardt, Ernst, Fagiolini, Fatemi, Fazio, Forrest, Forsythe, Friocourt, Gleeson, Gobaille, Goncalves, Guidetti, Guillemin, Guillemin, Gurdon, Harris, Harvey, Heng, Higgins, Higgins, Hilmas, Hiramatsu, Hoffman, Holtze, Hor, Hornig, Huang, Hynes, Ikonomidou, Iwasato, Jin, K. McNair, Kappeler, Kemp, Kerjan, L.G. Darlington, Larson, Leung, M. Pisar, M. Snitcofsky, Martel, Meyer, Miller, Mok, Munn, Myers, N. Gonzalez, Nacher, Nathan, Neale, Neher, Nilsson, Niswender, O.S. Khalil, Okuda, Otis, Ozaki, O’Kane, Palma, Parish, Pena, Perkins, Pfaffl, Pocivavsek, Potter, Prajerova, Rajan, Ramakers, Ramoa, Rodgers, Rosenmund, Röver, Saito, Saviane, Schwarcz, Schwarcz, Shin, Simon, Sims, Spassky, Stone, Stone, Stone, Stone, Stone, Stringer, T.W. Stone, Taleb, Tang, Traiffort, Traiffort, Traiffort, Traynelis, Udin, Ultanir, Vaillant, Vincent, Waldeck, Walker, Wang, Wang, Wierońska, Wu, Xiong, Zucker, Zuckerman   +144 more
core   +2 more sources

Exploring the pathophysiology underlying clozapine‐induced enhancement of glutamatergic transmission through L‐glutamate and D‐serine release associated with pannexin1 hemichannels

British Journal of Pharmacology, EarlyView.
Abstract Background and purpose Clozapine, an approved antipsychotic for treatment‐resistant schizophrenia (TRS), enhances glutamatergic transmission by increasing exocytosis and non‐exocytosis glutamate release; however, its full action remained to be clarified.
Motohiro Okada, Ruri Okubo, Eishi Motomura   +2 more
wiley   +1 more source