Results 81 to 90 of about 2,325,434 (292)

Genetic Insights and Lifelong Management of Aldosterone Synthase Deficiency: A Case of Hyperreninemic Hypoaldosteronism. [PDF]

Clin Case Rep
ABSTRACT Aldosterone synthase deficiency is a rare cause of neonatal salt‐wasting and failure to thrive. Routine newborn electrolyte screening after 5 days of life is vital for early detection and prevention of life‐threatening crises. Genetic confirmation enables targeted fludrocortisone therapy, ensuring favorable growth and developmental outcomes.
Ahmed MMH, Waris R, Batool S, Omarzai RG, Rehman A.   +4 more
europepmc   +2 more sources

Myocardial inflammation is associated with impaired mitochondrial oxidative capacity in ischaemic cardiomyopathy

ESC Heart Failure, Volume 12, Issue 2, Page 1246-1255, April 2025.
Abstract Aims Myocardial inflammation and impaired mitochondrial oxidative capacity are hallmarks of heart failure (HF) pathophysiology. The extent of myocardial inflammation in patients suffering from ischaemic cardiomyopathy (ICM) or dilated cardiomyopathy (DCM) and its association with mitochondrial energy metabolism are unknown.
Julius Borger, Elric Zweck, Constanze Moos, Patrick Horn, Fabian Voß, Heinz‐Peter Schultheiss, Jacob Eifer Møller, Udo Boeken, Hug Aubin, Artur Lichtenberg, Malte Kelm, Michael Roden, Amin Polzin, Ralf Westenfeld, Julia Szendroedi, Daniel Scheiber   +15 more
wiley   +1 more source

Effects of Mineralocorticoid Receptors Blockade on FearMemory Reconsolidation in Rats

Basic and Clinical Neuroscience, 2011
Reconsolidation memory is defined as a process in which the retrieval of a previously consolidated memory returns to a labile state which is then subject to stabilization.
Ali Rashidy-Pour, Saeed Nikzad, Roghyeh Pakdel, Abbas Ali Vafaei   +3 more
doaj   +2 more sources

THE USE OF MINERALOCORTICOID RECEPTOR ANTAGONISTS IN THE PRE VENTION OF ATRIAL FIBRILLATION

Архивъ внутренней медицины, 2019
Atrial fibrillation (AF) is one of the most common cardiac rhythm disorders. Its prevalence is about 1 % in the general population and exceeds 7 % in individuals older than 60 years of age.
N. T. Vatutin, A. N. Shevelok, G. G. Taradin, I. N. Kravchenko   +3 more
doaj   +1 more source

Projecting the benefit of vericiguat in PARADIGM‐HF and DAPA‐HF populations: Insights from the VICTORIA trial

ESC Heart Failure, Volume 12, Issue 2, Page 1479-1484, April 2025.
Abstract Aims The VICTORIA trial demonstrated a significant reduction in the primary composite outcome of heart failure (HF) hospitalization or cardiovascular death with vericiguat relative to placebo in high‐risk HF. This study aimed to contextualize treatment effects of vericiguat in populations with varying risk profiles simulated from the PARADIGM ...
Veraprapas Kittipibul, Robert J. Mentz, Rebecca Young, Javed Butler, Justin A. Ezekowitz, Carolyn S.P. Lam, Piotr Ponikowski, Adriaan Voors, Stefano Corda, Ciaran McMullan, Christopher M. O'Connor, Kevin J. Anstrom, Paul W. Armstrong, for the VICTORIA Study Group   +13 more
wiley   +1 more source

Therapeutic potential of finerenone for diabetic cardiomyopathy: focus on the mechanisms

Diabetology & Metabolic Syndrome
Diabetic cardiomyopathy (DCM) is a kind of myocardial disease that occurs in diabetes patients and cannot be explained by hypertensive heart disease, coronary atherosclerotic heart disease and other heart diseases. Its pathogenesis may be closely related
Jing Wang, Haojie Xue, Jinyu He, Li Deng, Julong Tian, Yang Jiang, Jian Feng   +6 more
doaj   +1 more source

Hsp90 blockers inhibit adipocyte differentiation and fat mass accumulation.

PLoS ONE, 2014
Geldanamycin derivatives are benzoquinone ansamycin antibiotics that bind to Hsp90 and alter its function. The alteration of Hsp90 activity limits some cellular hormonal responses by inhibiting nuclear receptors activation. The nuclear receptors activity,
Sébastien Desarzens, Wan-Hui Liao, Caterina Mammi, Massimiliano Caprio, Nourdine Faresse   +4 more
doaj   +1 more source

Epidemiology of hospitalized heart failure in France based on national data over 10 years, 2012–2022

ESC Heart Failure, Volume 12, Issue 2, Page 1283-1294, April 2025.
Abstract Aims We aim to describe the incidence of HF hospitalization in France in the post‐pandemic era, the prevalence of HF cases and patients' characteristics, management and outcomes while focusing on sex, age and socio‐economic differences and to analyse time‐trends between 2012 and 2022.
Valérie Olié, Richard Isnard, Françoise Pousset, Clémence Grave, Jacques Blacher, Amélie Gabet   +5 more
wiley   +1 more source

Role of the Renin-Angiotensin System and Aldosterone on Cardiometabolic Syndrome

International Journal of Hypertension, 2011
Aldosterone facilitates cardiovascular damage by increasing blood pressure and through different mechanisms that are independent of its effects on blood pressure.
P. Stiefel, A. J. Vallejo-Vaz, S. García Morillo, J. Villar   +3 more
doaj   +1 more source

Behavioral stress induces regionally-distinct shifts of brain mineralocorticoid and glucocorticoid receptor levels

Frontiers in Behavioral Neuroscience, 2014
Mineralocorticoid and glucocorticoid receptors (MRs and GRs) mediate the impact of stress on brain function primarily by affecting gene transcription in the cell nucleus. In vitro studies using hippocampal neurons indicate that MRs and GRs translocate to
Dorian eCaudal, Dorian eCaudal, Thérèse M. Jay, Thérèse M. Jay, Bill P. Godsil, Bill P. Godsil   +5 more
doaj   +1 more source