Results 161 to 170 of about 830 (216)

Senotherapeutics for Knee Osteoarthritis

Medicinal Research Reviews, EarlyView.
ABSTRACT Osteoarthritis (OA) is a chronic disease that imposes a significant economic burden and deteriorates quality of life. Nevertheless, current therapeutic options for OA are limited to symptomatic remedies. As such, there is a high interest in novel methods for treating or preventing OA.
Ezgi Duman, Girish Pattappa, Patrick Pann, Stephan Reppenhagen, Maximilian Rudert, Peter Angele, Denitsa Docheva   +6 more
wiley   +1 more source

Imaging patterns and genetic associations of brain atrophy across distinct symptom stages in Parkinson's disease

Neuroprotection, EarlyView.
Early disease stages showed limited cortical atrophy and enrichment of synaptic and calcium signaling pathways, whereas advanced stages demonstrated widespread cortical degeneration associated with immune activation and extracellular matrix remodeling.
Yi Ji, Liujia Lu, Kaidong Chen, Ruixuan Zhang, Yao Lu, Yachen Shi, Xiangming Fang   +6 more
wiley   +1 more source

Building a precision therapeutics program at a tertiary care children's hospital

Pediatric Investigation, EarlyView.
Luke Hamilton, Heidi Trinkman, Diana Carrasco, Kaitlin Smith, Kelly Vallance, Alejandra Dominguez, Danielle Miller, Megan Gibbs, Anish Ray   +8 more
wiley   +1 more source

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Characterization of Human Lymphocyte Surface Receptors for Mitogenic and Non‐mitogenic Substances

Scandinavian Journal of Immunology, 1980
To compare the receptor patterns for mitogenic and non‐mitogenic substances, surface glycoproteins of human lymphocytes were labelled with the lactoperioxidase‐catalysed iodination technique and with a galactose oxidase‐tritiated sodium borohydride technique.
V T, Skoog, S F, Nilsson, T H, Weber
openaire   +2 more sources

Relationship between mitogen receptors in peripheral blood lymphocytes and blastogenic responses to mitogen

Research in Veterinary Science, 1990
The relationship between the optimum concentration of mitogen which induces lymphocyte blastogenic response and the receptor occupancy by mitogen was investigated. The receptor occupancies which induced maximal blastogenic activity in equine, bovine and canine peripheral blood lymphocytes (PBL) were 31.1 per cent, 26.5 per cent and 38.4 per cent with ...
M, Tajima, T, Fujinaga, Y, Okamoto, K, Otomo, T, Koike   +4 more
openaire   +2 more sources

Lymphocyte membrane receptors in cultures treated with mitogens

Cellular Immunology, 1974
Abstract Lymphocyte membrane receptors for sheep erythrocytes (E) and human erythrocytes sensitized with antibody and complement (HEAC) were used as markers for human T and B cells, respectively. Combining the method of rosette formation with E and HEAC with radioautography, we have studied the effect of in vitro stimulation with phytohemagglutinin
Mendes, N. F., Zenha, M. J., Musatti, C. C., Naspitz, C. K.   +3 more
openaire   +3 more sources

Mitogenic stimulation and the redistribution of concanavalin A receptors on lymphocytes

Experimental Cell Research, 1981
Abstract When mouse spleen (Ig − ) cells undergo maximal mitogenic stimulation by optimal concentrations of concanavalin A (conA), the Ig − cells form caps of conA very slowly, with 50% of maximum cap formation occurring after about 10 h and maximal capping after about 24 h.
T, Pozzan, A N, Corps, T R, Hesketh, J C, Metcalfe   +3 more
openaire   +2 more sources

Mitogenic lectins bind to the antigen receptor on human lymphocytes

European Journal of Immunology, 1989
AbstractThe specificity of interactions between mitogenic and non‐mitogenic lectins and disulfide‐linked cell surface receptors on human lymphocytes was explored. Lysates (Nonidet‐P40) of surface‐radioiodinated tonsil lymphocytes and T lymphoblastoid cells (HPB‐ALL) were absorbed with lectin‐agarose derivatives (or bovine serum albumin, BSA‐agarose) or
O P, Chilson, A E, Kelly-Chilson
openaire   +2 more sources

Dilsulfide‐linked receptors for mitogenic lectins on piglet lymphocytes

European Journal of Immunology, 1988
AbstractThe interaction between leucoagglutinating phytohemagglutinin (L‐PHA), con‐canavalin A (Con A), soybean agglutinin (SBA) and lentil lectin (LcH) with disulfide‐linked cell surface receptors & lymphocytes from mesenteric lymph nodes of 3‐day piglets (PMLN) was investigated.
O P, Chilson, A E, Kelly-Chilson
openaire   +2 more sources

Differential regulation of accessory mitogenic signaling receptors by the T cell antigen receptor

Molecular Immunology, 1995
In addition to the antigen receptor, resting T cells express a number of receptors that can be stimulated to generate proliferative signals. These "accessory" receptors require co-expression of the T cell receptor (TCR), suggesting that they channel their signals via secondary activation of the signal transduction function of the CD3-TCR complex ...
X M, Zhang, R, Berland, P M, Rosoff
openaire   +2 more sources