Results 171 to 180 of about 830 (216)
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Characterization of the mitogen-regulated protein (proliferin) receptor.
Endocrinology, 1995Mitogen-regulated protein (MRP/PLF; also called proliferin) is a member of the PRL-GH family expressed by the placenta in mid-gestation. This report describes an MRP/PLF receptor in uterine membrane preparations from pregnant mice. Peak receptor activity occurred at 11 days of gestation with a dissociation constant of 6 x 10(-10) M and maximal binding ...
J T, Nelson +2 more
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The control of transferrin receptor synthesis in mitogen-stimulated human lymphocytes
Experimental Cell Research, 1984Human lymphocytes cultured in the presence of the plant mitogenic lectin phytohemagglutin in (PHA) become activated and leave the G0 phase of the cell cycle. In the presence of PHA and lymphokines produced in situ the cells will enter S phase and undergo cell division. We have determined the time course of appearance for the receptor for transferrin as
C D, Pauza, J D, Bleil, E S, Lennox
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Progress in clinical and biological research, 1977
125I-Insulin was used as a model mitogen to examine the relationships of mitogen receptor occupancy and exposure in controlling cell replication. Labeled hormone was bound to substratum-attached, confluent fibroblasts with two affinities, K1 approximately equal to 2 X 108 M-1 and K2 approximately equal to 0.8 X 107 M-1.
J F, Perdue, M K, Raizada
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125I-Insulin was used as a model mitogen to examine the relationships of mitogen receptor occupancy and exposure in controlling cell replication. Labeled hormone was bound to substratum-attached, confluent fibroblasts with two affinities, K1 approximately equal to 2 X 108 M-1 and K2 approximately equal to 0.8 X 107 M-1.
J F, Perdue, M K, Raizada
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Effects of mitogens on ADCC activity and Fc receptor bearing cells
Experientia, 1983Murine spleen cells, when activated by various mitogens (Con A, PHA, LPS, BCG) or Con-A conditioned medium show altered behavior as effector cells of antibody-mediated cell cytotoxicity (ADCC) which does not correlate with the expression of Fc-receptors (FcR) at the effector cell surface.
Hugin, A, Matter, A
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Signalling from adenosine receptors to mitogen-activated protein kinases
Cellular Signalling, 2003The purine nucleoside adenosine acts via four distinct adenosine receptor subtypes: the adenosine A(1), A(2A), A(2B), and A(3) receptor. They are all G protein-coupled receptors (GPCR) coupling to classical second messenger pathways such as modulation of cAMP production or the phospholipase C (PLC) pathway. In addition, they couple to mitogen-activated
Gunnar, Schulte, Bertil B, Fredholm
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Mitogenic signalling by B2 bradykinin receptor in epithelial breast cells
Journal of Cellular Physiology, 2004AbstractThe kinin peptides are released during inflammation and are amongst the most potent known mediators of vasodilatation, pain, and oedema. A role in the modulation or induction of healthy breast tissue growth has been postulated for tissue kallikrein present in human milk. Moreover, tissue kallikrein was found in malignant human breast tissue and
GRECO S +5 more
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Relationship of Estrogen Receptors and Protein Synthesis to the Mitogenic Effect of Estrogens*
Endocrinology, 19851,3,5(10)-Estratriene-3,16 alpha-diol (16 alpha-E2) is an estrogen which is ineffective in stimulating DNA synthesis in the prepuberal rat uterus when administered to rats in a single injection in doses up to at least 5 micrograms. However, it acquires the same high mitogenic potency as 1,3,5(10)-estratriene-3,17 beta-diol (17 beta-E2) if a 5 ...
G, Stack, J, Gorski
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Tumor necrosis factor: Receptor binding and mitogenic action in fibroblasts
Journal of Cellular Physiology, 1987Until about two years ago, the only known function of tumor necrosis factor (TNF) was inhibition of tumor growth. Since then it has become apparent that many types of normal and transformed cells express specific high-affinity TNF receptors (Kd 200 pM) and that the presence of receptors does not correlate with susceptibility to the cytotoxic/cytostatic
J, Vilcek +4 more
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Evidence that the TSH receptor acts as a mitogenic antigen in Graves' disease
Nature, 1978GRAVES' DISEASE (GD) is an autoimmune disorder associated with the formation of thyroid antibodies, one class of which, thyroid-stimulating antibodies (TSAb), is thought to be involved in the pathogenesis1–3. TSAb act similarly to thyrotropin (TSH) on the thyroid follicle cell through the mediation of adenylate cyclase4.
T, Mäkinen +4 more
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Receptor-mediated regulation of mitogenic response.
Clinical and experimental immunology, 1982We have investigated the requirements of mitogenic response of mouse spleen cells for free and cell-bound concanavalin A (Con A) and inhibition of the response by egg lecithin. We also studied 125I-Con A binding with the mouse cells at different times after stimulation with the lectin.
M H, Ng, W S, Ng, T K, Siu
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