Results 161 to 170 of about 83,236 (271)

Modeling presynaptic inhibition by the amyloid precursor protein demonstrates one potential mechanism for preventing runaway synaptic modification in Alzheimer's disease

Alzheimer's &Dementia, Volume 21, Issue 10, October 2025.
Abstract INTRODUCTION Previous simulations of Hebbian associative memory models inspired the malignant synaptic growth hypothesis of Alzheimer's disease (AD), which suggests that cognitive impairments arise due to runaway synaptic modification resulting from poor separation between encoding and retrieval.
Dylan Barber, Michael E. Hasselmo, Heather C. Rice   +2 more
wiley   +1 more source

Xerostomia as a Rare Adverse Effect of Low‐Dose Oral Minoxidil: A Case Report With Recurrence After Rechallenge

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Low‐dose oral minoxidil (LDOM) is an emerging option for the treatment of female pattern hair loss (FPHL), generally well tolerated at doses under 1 mg/day. We report a rare adverse event of significant xerostomia in a 74‐year‐old woman with Hashimoto's thyroiditis, receiving 0.5 mg/day of minoxidil for FPHL.
Nicolò Rivetti
wiley   +1 more source

Xanomeline/trospium-induced polyuria: A patient case report. [PDF]

Ment Health Clin
Leach H, DiGuglielmo F.
europepmc   +1 more source

Targeting muscarinic receptors in schizophrenia treatment: Novel antipsychotic xanomeline/trospium chloride. [PDF]

World J Psychiatry
Pejčić AV.
europepmc   +1 more source

Pediatric Anesthetic Management of a Patient With Warburg Micro Syndrome, a Rare Autosomal Recessive Genetic Disorder

Clinical Case Reports, Volume 13, Issue 10, October 2025.
ABSTRACT Warburg micro syndrome is an extremely rare autosomal recessive genetic disorder with only 100 families documented worldwide. We present a safe and successful anesthetic management of a pediatric patient with Warburg micro syndrome utilizing total intravenous anesthesia (TIVA) and incisional Exparel.
Esha Thakkar, Michael McNally, Adrienne Hutton, Michael Holdeman, David G. Jackson   +4 more
wiley   +1 more source

Physiological Significance of Endothelial M3 Muscarinic Receptors During Exercise. [PDF]

Circ Res
Ackland GL, Hosford PS, Gutierrez Del Arroyo A, Korsak A, Machhada A, Pickard J, Gomez De La Torre GG, Stuckey DJ, Tinker A, Tobin AB, Jeon J, Wess J, Gourine AV.   +12 more
europepmc   +1 more source

Does Adding Electroanalgesic Modalities to a Multimodal Therapeutic Program Improve Clinical Outcomes in Individuals With Chronic Nonspecific Neck Pain? A Randomised Controlled Trial

European Journal of Pain, Volume 29, Issue 9, October 2025.
ABSTRACT Background Chronic nonspecific neck pain (CNSNP) is a prevalent and complex condition. Although many studies have evaluated the effectiveness of transcutaneous electrical nerve stimulation (TENS), interferential current (IFC), therapeutic exercise (TE), and manual therapy (MT) individually, this study aimed to determine whether adding IFC and ...
Gabriela Nascimento de Santana, Aron Charles Barbosa da Silva, Patrícia Gabrielle dos Santos, Carlos Eduardo Girasol, Adriano Rodrigues de Oliveira, Almir Vieira Dibai‐Filho, Cid André Fidelis de Paula Gomes   +6 more
wiley   +1 more source

Considerations for Augmenting Aripiprazole Long-Acting Injectables with Other Antipsychotics: A Mini-Review. [PDF]

Diseases
Shaw J, Kim E, Ton E, Lai C, Bota P, Allee T.   +5 more
europepmc   +1 more source

Administration of Metoclopramide Prior to Endoscopy for Acute Upper Gastrointestinal Bleeding: A Systematic Review and GRADE Meta‐Analysis of Randomized Controlled Trials

JGH Open, Volume 9, Issue 10, October 2025.
ABSTRACT Acute Upper Gastrointestinal Bleeding (UGIB) is a critical condition where endoscopy is often hindered by poor visibility. This meta‐analysis assesses the safety and efficacy of metoclopramide as a pre‐endoscopic aid to improve visualization.
Muhammad Hassan Waseem, Zain Ul Abideen, Ayesha Ahmed, Barka Sajid, Noor Ul Huda Ramzan, Amina Tahir, Sania Aimen, Muhammad Arslan Tariq, Aleeza Afzal, Pawan Kumar Thada, Ameer Haider Cheema   +10 more
wiley   +1 more source