Results 1 to 10 of about 91,275 (311)
Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy [PDF]
Frontiers in Molecular Neuroscience, 2022 Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal ...
Shuang Chen +5 more
doaj +3 more sources
Long-term potentiation and the role of N-methyl-d-aspartate receptors [PDF]
Brain Research, 2015 N-methyl-D-aspartate receptors (NMDARs) are known for their role in the induction of long-term potentiation (LTP). Here we start by reviewing the early evidence for their role in LTP at CA1 synapses in the hippocampus. We then discuss more recent evidence that NMDAR dependent synaptic plasticity at these synapses can be separated into mechanistically ...
A. Volianskis +5 more
semanticscholar +6 more sources
Acute and chronic excitotoxicity in ischemic stroke and late-onset Alzheimer’s disease [PDF]
Neural Regeneration ResearchStroke and Alzheimer’s disease are common neurological disorders and often occur in the same individuals. The comorbidity of the two neurological disorders represents a grave health threat to older populations.
Shan Ping Yu +3 more
doaj +2 more sources
Protein quality control of N-methyl-D-aspartate receptors
Frontiers in Cellular Neuroscience, 2022 N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated cation channels that mediate excitatory neurotransmission and are critical for synaptic development and plasticity in the mammalian central nervous system (CNS). Functional NMDARs typically form
Taylor M. Benske +2 more
doaj +2 more sources
At least three xenon binding sites in the glycine binding domain of the N-methyl D-aspartate receptor [PDF]
Archives of Biochemistry and Biophysics 2022, vol.724, 109265, 2022 Xenon can produce general anesthesia. Its main protein target is the N-methyl-D-aspartate receptor, a ionotropic channel playing a pivotal role in the function of the central nervous system. The molecular mechanisms allowing this noble gas to have such a specific effect remain obscure, probably as a consequence of the lack of structural data at the ...
arxiv +1 more source
Frontiers in Psychiatry, 2023 BackgroundAntibodies against N-methyl-D-aspartate receptors are the most commonly identified cause of autoimmune encephalitis. While predominantly associated with malignancies, cases of anti-N-methyl-D-aspartate receptor autoimmune encephalitis have been
Thomas Hainmueller +4 more
doaj +1 more source
The Journal of Poultry Science, 2020 L-Pipecolic acid is an intermediate of L-lysine catabolism. Its central injection exerted a hypnotic effect on the brain, which was partially mediated by the activation of γ-aminobutyric acid-A and γ-aminobutyric acid-B receptors. L-Proline has also been
Asako Shigemura +2 more
doaj +1 more source
Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. [PDF]
PLoS ONE, 2013 It has been reported that both activation of N-methyl-D-aspartate receptors and acid-sensing ion channels during cerebral ischemic insult contributed to brain injury.
Kwok Keung Tai, Daniel D Truong
doaj +1 more source
Anti-N-Methyl-D-Aspartate Receptor Encephalitis
Pediatric Neurology Briefs, 2013 Investigators at Universities of Barcelona, Pennsylvania, Oviedo, and Valencia, and the Spanish NMDAR Encephalitis Work Group report the clinical features of 20 pediatric patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis seen in a single center in Spain in the last 4 years.
Kenneth Nugent +5 more
+10 more sources
Pharmacology of triheteromeric N-Methyl-d-Aspartate Receptors [PDF]
Neuroscience Letters, 2016 The N-Methyl-D-Aspartate Receptors (NMDARs) are heteromeric cation channels involved in learning, memory, and synaptic plasticity, and their dysregulation leads to various neurodegenerative disorders. Recent evidence has shown that apart from the GluN1/GluN2A and GluN1/GluN2B diheteromeric ion channels, the NMDAR also exists as a GluN1/GluN2A/GluN2B ...
Kasper B. Hansen +3 more
openaire +3 more sources