Results 161 to 170 of about 115,612 (189)

N-Methyl-D-Aspartate Receptors in the Retina

Molecular Neurobiology, 2006
The vertebrate retina is a "genuine neural center" (Ramón y Cajal), in which glutamate is a major excitatory neurotransmitter. Both N-methyl-D-aspartate (NMDA) and non-NMDA receptors are expressed in the retina. Although non-NMDA receptors and/or metabotropic glutamate receptors are generally thought to be responsible for mediating the transfer of ...
Xiao-Ling Liu, Yin Shen, Xiong-Li Yang
openaire   +3 more sources

The N-Methyl-D-Aspartate Receptor Complex

Journal of Receptor Research, 1988
The effects of agonists of the N-methyl-D-aspartate (NMDA) receptor can be blocked by dissociative anesthetics such as phencyclidine (PCP) in a non-competitive manner. This finding together with the fact that ligand binding to the PCP receptor is dependent on the presence of L-glutamate has led to the suggestion that there may exist an NMDA/PCP ...
Albert Braunwalder, Patricia Loo, Michael F. Jarvis, Michael Williams, Matthew A. Sills, Deborah E. Murphy   +5 more
openaire   +3 more sources

N-methyl-d-aspartate receptors and pain

Current Opinion in Anaesthesiology, 1995
The N-methyl-d-aspartate subtype of excitatory amino acid receptor is abundantly distributed throughout the central nervous system and is intimately associated with physiologic processes underlying acute and chronic pain states.
Richard M. Kream, Andrew W. Sukiennik
openaire   +2 more sources

Assembly of N-methyl-d-aspartate (NMDA) receptors

Biochemical Society Transactions, 2003
The N-methyl-d-aspartate receptor (NMDAR) requires both NR1 and NR2 subunits to form a functional ion channel. Despite the recent advances in our understanding of the contributions of these different subunits to both the function and pharmacology of the NMDAR, the precise subunit stoichiometry of the receptor and the regions of the subunits governing ...
R.A.J. McIlhinney, S. Sandhu, Paul J. Whiting, Keith A. Wafford, B. Le Bourdelles, Sarah Grimwood, E. Philipps   +6 more
openaire   +3 more sources

N-methyl-D-aspartate receptors and Alzheimer's disease

Neurobiology of Aging, 1989
The results of several studies now suggest that the density of N-methyl-D-aspartate (NMDA) receptors is maintained in many Alzheimer's disease (AD) cases, although loss of these receptors can occur in specific regions as a consequence of severe neuronal loss.
Carl W. Cotman, Richard J. Bridges, James W. Geddes, Daniel T. Monaghan   +3 more
openaire   +2 more sources

The pharmacology of tacrine at N -methyl- d -aspartate receptors

Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2017
The mechanism of tacrine as a precognitive drug has been considered to be complex and not fully understood. It has been reported to involve a wide spectrum of targets involving cholinergic, gabaergic, nitrinergic and glutamatergic pathways. Here, we review the effect of tacrine and its derivatives on the NMDA receptors (NMDAR) with a focus on the ...
Martin Horak, Kristina Holubova, Eugenie Nepovimova, Jan Krusek, Martina Kaniakova, Jan Korabecny, Ladislav Vyklicky, Kamil Kuca, Ales Stuchlik, Jan Ricny, Karel Vales, Ondrej Soukup   +11 more
openaire   +3 more sources

Temperature dependence of N-methyl-d-aspartate receptor channels and N-methyl-d-aspartate receptor excitatory postsynaptic currents

Neuroscience, 2010
N-methyl-d-aspartate (NMDA) receptors (NMDARs) are highly expressed in the CNS and mediate the slow component of excitatory transmission. The present study was aimed at characterizing the temperature dependence of the kinetic properties of native NMDARs, with special emphasis on the deactivation of synaptic NMDARs.
Miloslav Korinek, O. Cais, M. Sedlacek, Ivan Dittert, Ladislav Vyklicky   +4 more
openaire   +2 more sources

Allosteric Modulation of N-Methyl-D-Aspartate Receptors

1990
In this review we have attempted to describe the basis for current models of the NMDA receptor, and justify the need for the various binding sites that have been proposed. The NMDA receptor is clearly a complex molecule with a number of modulatory sites, any of which may have great functional significance.
Richard J. Miller, Richard J. Miller, Ian J. Reynolds, Ian J. Reynolds   +3 more
openaire   +3 more sources

Novel Pyrrolinones as N‐Methyl‐D‐aspartate Receptor Antagonists.

ChemInform, 2005
AbstractFor Abstract see ChemInform Abstract in Full Text.
Peter Mayer, Georg Höfner, Hans-Dietrich Stachel, Hermann Poschenrieder   +3 more
openaire   +4 more sources