Results 171 to 180 of about 115,612 (189)
Some of the next articles are maybe not open access.
Modeling of N-Methyl-D-Aspartate Receptors
2019Several reduced kinetic models for N-methyl-D-aspartate receptors were derived in order to suit different experimental protocols. Their simultaneous application allows for a step-wise estimation of parameters of a conventional model that is otherwise overparameterized with respect to the existing data.
Leonid V. Kalachev +2 more
openaire +2 more sources
International Journal of Gynecological Pathology, 2014
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common antibody-mediated limbic encephalitis and is associated with underlying ovarian teratoma. Previous studies suggest that expression of NMDAR on teratoma neural tissue initiates an autoimmune response to NMDAR in the brain.
Lawrence R. Zukerberg +5 more
openaire +3 more sources
Anti-N-methyl-D-aspartate receptor (anti-NMDAR) encephalitis is the most common antibody-mediated limbic encephalitis and is associated with underlying ovarian teratoma. Previous studies suggest that expression of NMDAR on teratoma neural tissue initiates an autoimmune response to NMDAR in the brain.
Lawrence R. Zukerberg +5 more
openaire +3 more sources
Excitotoxicity and N‐methyl‐D‐Aspartate receptors
Drug Development Research, 1989AbstractA great deal of new information has been generated over the past decade in the excitatory amino acid (EAA) field. Not only have endogenous EAA such as glutamate and aspartate become recognized as the leading neurotransmitter candidates at the majority of excitatory synapses in the mammalian central nervous system, but it is becoming ...
openaire +2 more sources
NeuroReport, 2008
We hypothesized that proteins from the GRINL1A complex transcription unit called Gcom proteins modulate glutamatergic neurotransmission through interaction with the NR1 subunit of the N-methyl D-aspartate (NMDA) receptor. Cotransfection of hemagglutinin-tagged Gcom1 (GRINL1A combined transcript 1) and NR1 cDNAs into HEK293 cells revealed overlapping ...
Mohan R. Nair +5 more
openaire +3 more sources
We hypothesized that proteins from the GRINL1A complex transcription unit called Gcom proteins modulate glutamatergic neurotransmission through interaction with the NR1 subunit of the N-methyl D-aspartate (NMDA) receptor. Cotransfection of hemagglutinin-tagged Gcom1 (GRINL1A combined transcript 1) and NR1 cDNAs into HEK293 cells revealed overlapping ...
Mohan R. Nair +5 more
openaire +3 more sources
Neuroscience, 1999
Interest in the fundamental mechanisms underlying headache, particularly the pathophysiology of migraine and cluster headache, has lead to the study of the physiology and pharmacology of the trigeminovascular system and its central ramifications. Cats were anaesthetized (60 mg/kg alpha-chloralose, i.p., along with halothane for all surgical procedures)
RJ Storer, Peter J. Goadsby
openaire +3 more sources
Interest in the fundamental mechanisms underlying headache, particularly the pathophysiology of migraine and cluster headache, has lead to the study of the physiology and pharmacology of the trigeminovascular system and its central ramifications. Cats were anaesthetized (60 mg/kg alpha-chloralose, i.p., along with halothane for all surgical procedures)
RJ Storer, Peter J. Goadsby
openaire +3 more sources
Proteolysis of the N-Methyl-d-Aspartate Receptor by Calpain in Situ [PDF]
The Journal of Pharmacology and Experimental Therapeutics, 2002 N-Methyl-D-aspartate (NMDA) receptors are calcium-permeable glutamate receptors that play putative roles in learning, memory, and excitotoxicity. NMDA receptor-mediated calcium entry can activate the calcium-dependent protease calpain, leading to substrate degradation. The major NMDA receptor 2 (NR2) subunits of the receptor are in vitro substrates for
David A. Lynch +5 more
openaire +2 more sources
The role of N-methyl-D-aspartate receptor in Alzheimer's disease
Journal of the Neurological Sciences, 2014Alzheimer's disease (AD) is a neurodegenerative disease characterized by cognitive disorder and memory dysfunction. This kind of cognitive impairment is closely related to synaptic plasticity, in which N-methyl-D-aspartate receptor (NMDAR), which is one of the glutamate receptors, plays a critical role.
Junsi Zhang +3 more
openaire +3 more sources
Deramciclane inhibits N-methyl-D-aspartate receptor function
Brain Research Bulletin, 2000Effects of the novel anxiolytic drug deramciclane on excitatory amino acid release and transmembrane Ca(2+) ion flux processes were compared in rat cerebrocortical homogenates containing resealed plasmalemma fragments and nerve endings. Deramciclane (10 microM) significantly inhibited [(3)H]D-aspartate release and transmembrane Ca(2+) flux to N-methyl ...
Ilona Kovács +3 more
openaire +3 more sources
The promise of N-methyl-d-aspartate receptor antagonists in fibromyalgia
Rheumatic Disease Clinics of North America, 2002There is strong evidence that intravenous administration of ketamine following a standardized protocol could be used as a diagnostic test for a central sensitization in the central nervous system in patients with FM. The combination of a weak opioid and an NMDA-receptor antagonist with few side effects is presently a promise for treatment of pain in a ...
Jan Sörensen, K. G. Henriksson
openaire +3 more sources
Felbamate block of the N-methyl-D-aspartate receptor.
The Journal of Pharmacology and Experimental Therapeutics, 1995The anticonvulsant felbamate may act as an N-methyl-D-aspartate (NMDA) receptor antagonist, but the mechanism of block has not been fully characterized. We sought to identify the sites at which felbamate exerts its NMDA receptor blocking action using radioligand binding to rat forebrain membranes and whole-cell voltage clamp and single-channel ...
S, Subramaniam +5 more
openaire +2 more sources