Role of N-methyl-D-aspartate receptors in action-based predictive coding deficits in schizophrenia [PDF]
, 2017 Published in final edited form as:Biol Psychiatry. 2017 March 15; 81(6): 514–524. doi:10.1016/j.biopsych.2016.06.019.BACKGROUND: Recent theoretical models of schizophrenia posit that dysfunction of the neural mechanisms subserving predictive coding ...
Ford, Judith M. +7 more
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Pharmacology of triheteromeric N-Methyl-d-Aspartate Receptors [PDF]
Neuroscience Letters, 2016 The N-Methyl-D-Aspartate Receptors (NMDARs) are heteromeric cation channels involved in learning, memory, and synaptic plasticity, and their dysregulation leads to various neurodegenerative disorders. Recent evidence has shown that apart from the GluN1/GluN2A and GluN1/GluN2B diheteromeric ion channels, the NMDAR also exists as a GluN1/GluN2A/GluN2B ...
John, Cheriyan +3 more
openaire +2 more sources
N-Methyl-D-Aspartate Receptors in Hematopoietic Cells: What Have We Learned?
Frontiers in Physiology, 2020 The N-methyl-D-aspartate receptor (NMDAR) provides a pathway for glutamate-mediated inter-cellular communication, best known for its role in the brain but with multiple examples of functionality in non-neuronal cells.
Maggie L. Kalev-Zylinska +6 more
doaj +1 more source
In silico investigation on the probable macromolecular drug targets involved in the anti-schizophrenia activity of Nardostachys jatamansi [PDF]
Brazilian Journal of Pharmaceutical Sciences, 2022 Existing medications i.e. the antipsychotic drugs are known to be effective in treating only the positive symptoms of schizophrenia, while being ineffective on negative and cognitive symptoms of the disease.
Foong Xi Wei +2 more
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NR2A- and NR2B-containing NMDA Receptors in the Prelimbic Medial Prefrontal Cortex Differentially Mediate Trace, Delay, and Contextual Fear Conditioning [PDF]
, 2013 Activation of N-methyl-D-aspartate receptors (NMDAR) in the prelimbic medial prefrontal cortex (PL mPFC) is necessary for the acquisition of both trace and contextual fear memories, but it is not known how specific NR2 subunits support each association ...
Gilmartin, Marieke R. +2 more
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Anti-N-methyl-D-aspartate receptor encephalitis: analysis of three cases
Chinese Journal of Contemporary Neurology and Neurosurgery, 2018 Objective To explore the clinical features, diagnosis, treatment and prognosis of patients with anti-N-methyl-D-aspartate (NMDA) receptor encephalitis.
Ya-nan TIAN
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Positive allosteric modulation as a potential therapeutic strategy in anti-NMDA receptor encephalitis [PDF]
, 2018 N-methyl-d-aspartate receptors (NMDARs) are ionotropic glutamate receptors important for synaptic plasticity, memory, and neuropsychiatric health. NMDAR hypofunction contributes to multiple disorders, including anti-NMDAR encephalitis (NMDARE), an ...
Benz, Ann +11 more
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Journal of Neuroscience, 1990 Dose-response curves for activation of excitatory amino acid receptors on mouse embryonic hippocampal neurons in culture were recorded for 15 excitatory amino acids, including the L-isomers of glutamate, aspartate, and a family of endogenous sulfur amino
DK Patneau, M. Mayer
semanticscholar +1 more source
Spatial and temporal boundaries of NMDA receptor hypofunction leading to schizophrenia
npj Schizophrenia, 2017 The N-methyl-d-aspartate receptor hypofunction is one of the most prevalent models of schizophrenia. For example, healthy subjects treated with uncompetitive N-methyl-d-aspartate receptor antagonists elicit positive, negative, and cognitive-like symptoms
Kazu Nakazawa +2 more
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Research progress of N⁃methyl⁃D⁃aspartate receptor GRIN2A gene variations and epilepsy
Chinese Journal of Contemporary Neurology and Neurosurgery, 2023 In recent years, with the rapid development of gene sequencing technology, a variety of epilepsy pathogenic genes have been discovered, among which GRIN2A gene variations encoding the neurotransmitter N⁃methyl⁃D⁃aspartate receptor (NMDAR) are closely ...
TANG Wei⁃ting, XIAO Bo
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