Results 11 to 20 of about 149,284 (337)

Roles of N-Methyl-D-Aspartate Receptors (NMDARs) in Epilepsy [PDF]

Frontiers in Molecular Neuroscience, 2022
Epilepsy is one of the most common neurological disorders characterized by recurrent seizures. The mechanism of epilepsy remains unclear and previous studies suggest that N-methyl-D-aspartate receptors (NMDARs) play an important role in abnormal ...
Shuang Chen, Da Xu, Liu Fan, Zhi Fang, Xiufeng Wang, Man Li   +5 more
doaj   +3 more sources

Protein quality control of N-methyl-D-aspartate receptors

Frontiers in Cellular Neuroscience, 2022
N-methyl-D-aspartate receptors (NMDARs) are glutamate-gated cation channels that mediate excitatory neurotransmission and are critical for synaptic development and plasticity in the mammalian central nervous system (CNS). Functional NMDARs typically form
Taylor M. Benske, Ting-Wei Mu, Ya-Juan Wang   +2 more
doaj   +3 more sources

Case report: Anti N-methyl-D-aspartate autoimmune encephalitis following a mildly symptomatic COVID-19 infection in an adolescent male [PDF]

Frontiers in Psychiatry, 2023
BackgroundAntibodies against N-methyl-D-aspartate receptors are the most commonly identified cause of autoimmune encephalitis. While predominantly associated with malignancies, cases of anti-N-methyl-D-aspartate receptor autoimmune encephalitis have been
Thomas Hainmueller, Lambert Lewis, Lambert Lewis, Tzvi Furer, Tzvi Furer   +4 more
doaj   +3 more sources

Long-term potentiation and the role of N-methyl-d-aspartate receptors [PDF]

Brain Research, 2015
N-methyl-D-aspartate receptors (NMDARs) are known for their role in the induction of long-term potentiation (LTP). Here we start by reviewing the early evidence for their role in LTP at CA1 synapses in the hippocampus. We then discuss more recent evidence that NMDAR dependent synaptic plasticity at these synapses can be separated into mechanistically ...
A. Volianskis, G. France, M. Jensen, Z. Bortolotto, D. Jane, G. Collingridge   +5 more
semanticscholar   +6 more sources

Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors [PDF]

Journal of Neuroinflammation, 2004
Background Neuroinflammation plays a prominent role in the progression of Alzheimer's disease and may be responsible for degeneration in vulnerable regions such as the hippocampus.
Hauss-Wegrzyniak Beatrice, Ramirez-Amaya Victor, Rosi Susanna, Wenk Gary L   +3 more
doaj   +4 more sources

Intracerebroventricular Injection of L-Pipecolic Acid Exerts Hypnotic Effects Without Activating NMDA Receptors in Neonatal Chicks under Social Isolation-induced Stress

The Journal of Poultry Science, 2020
L-Pipecolic acid is an intermediate of L-lysine catabolism. Its central injection exerted a hypnotic effect on the brain, which was partially mediated by the activation of γ-aminobutyric acid-A and γ-aminobutyric acid-B receptors. L-Proline has also been
Asako Shigemura, Vishwajit S. Chowdhury, Mitsuhiro Furuse   +2 more
doaj   +1 more source

Amiloride but not memantine reduces neurodegeneration, seizures and myoclonic jerks in rats with cardiac arrest-induced global cerebral hypoxia and reperfusion. [PDF]

PLoS ONE, 2013
It has been reported that both activation of N-methyl-D-aspartate receptors and acid-sensing ion channels during cerebral ischemic insult contributed to brain injury.
Kwok Keung Tai, Daniel D Truong
doaj   +1 more source

Anti-N-Methyl-D-Aspartate Receptor Encephalitis

Pediatric Neurology Briefs, 2013
Investigators at Universities of Barcelona, Pennsylvania, Oviedo, and Valencia, and the Spanish NMDAR Encephalitis Work Group report the clinical features of 20 pediatric patients with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis seen in a single center in Spain in the last 4 years.
Kenneth Nugent, Charoen Mankongpaisarnrung, Ragesh Panikkath, Ebtesam Islam, Zachary Mulkey, Sian Yik Lim   +5 more
  +10 more sources

Pharmacology of triheteromeric N-Methyl-d-Aspartate Receptors [PDF]

Neuroscience Letters, 2016
The N-Methyl-D-Aspartate Receptors (NMDARs) are heteromeric cation channels involved in learning, memory, and synaptic plasticity, and their dysregulation leads to various neurodegenerative disorders. Recent evidence has shown that apart from the GluN1/GluN2A and GluN1/GluN2B diheteromeric ion channels, the NMDAR also exists as a GluN1/GluN2A/GluN2B ...
Kasper B. Hansen, John Cheriyan, Rashna D. Balsara, Francis J. Castellino   +3 more
openaire   +3 more sources

Cardiac N-methyl d-aspartate Receptors as a Pharmacological Target [PDF]

Journal of Cardiovascular Pharmacology, 2016
Abstract: This study focuses on characterization of the cardiac N-methyl d-aspartate receptors (NMDARs) as a target for endogenous and synthetic agonists and antagonists. Using isolated perfused rat hearts, we have shown that intracoronary administration of the NMDAR agonists and antagonists has a pronounced effect on autonomous heart ...
Makhro, Asya, Tian, Qinghai, Kaestner, Lars, Kosenkov, Dmitry, Faggian, Giuseppe, Gassmann, Max, Schwarzwald, Colin, Bogdanova, Anna   +7 more
openaire   +4 more sources