Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells [PDF]
, 2005 [Abstract] Glutamate is thought to be the excitatory neurotransmitter in the lateral geniculate nucleus (LGN) of the cat, mediating visual transmission from the retina via ionotropic receptors of both d,l-α-amino-3-hydroxy-5-α-methyl-4 ...
Cudeiro, Javier +2 more
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Uses of magnesium sulfate in anesthesiology
Revista Médica del Hospital General de México, 2022 Introduction: Magnesium sulfate heptahydrate (MgSO4 7H2O) is a divalent cation, pharmacologically its mechanism has been as a reversible blocker of the N-methyl-D-aspartate receptor (NMDAR) and therefore has been proposed in the use of anesthesiology ...
Claudia I. Gutiérrez-Román +2 more
doaj +1 more source
An expanding range of targets for kynurenine metabolites of tryptophan [PDF]
, 2013 The kynurenine pathway of tryptophan metabolism accounts for most of the tryptophan that is not committed to protein synthesis and includes compounds active in the nervous and immune systems.
Darlington, L. Gail +2 more
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Ketamine: NMDA receptors and beyond [PDF]
, 2016 Human studies examining the effects of the dissociative anesthetic ketamine as a model for psychosis and as a rapidly acting antidepressant have spurred great interest in understanding ketamine's actions at molecular, cellular, and network levels ...
Izumi, Yukitoshi +2 more
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Effects of sarcosine and N, N-dimethylglycine on NMDA receptor-mediated excitatory field potentials [PDF]
, 2017 BACKGROUND: Sarcosine, a glycine transporter type 1 inhibitor and an N-methyl-D-aspartate (NMDA) receptor co-agonist at the glycine binding site, potentiates NMDA receptor function.
Hwei-Hsien Chen +5 more
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In developing hippocampal neurons, NR2B-containing N-methyl-d-aspartate receptors (NMDARs) can mediate signaling to neuronal survival and synaptic potentiation, as well as neuronal death [PDF]
, 2009 It has been suggested that NR2B-containing N-methyl-d-aspartate (NMDA) receptors have a selective tendency to promote pro-death signaling and synaptic depression, compared with the survival promoting, synapse potentiating properties of NR2A-containing ...
Hardingham, G.E. +2 more
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The GluN3 subunit regulates ion selectivity within native N-methyl-d-aspartate receptors
IBRO Reports, 2020 Glutamatergic N-methyl-d-aspartate receptors (NMDARs) are heterotetrameric proteins whose subunits are derived from three gene families, GRIN1 (codes for GluN1), GRIN2 (GluN2) and GRIN3 (GluN3).
Stephen Beesley +2 more
doaj +1 more source
Journal of Neuroscience, 2013 N-methyl-d-aspartate receptors (NMDARs) are glutamate-gated ion channels that are critical to the regulation of excitatory synaptic function in the CNS.
S. Paul +11 more
semanticscholar +1 more source
Block of NMDA receptor channels by endogenous neurosteroids: implications for the agonist induced conformational states of the channel vestibule [PDF]
, 2015 N-methyl-D-aspartate receptors (NMDARs) mediate synaptic plasticity, and their dysfunction is implicated in multiple brain disorders. NMDARs can be allosterically modulated by numerous compounds, including endogenous neurosteroid pregnanolone sulfate ...
A Malayev +61 more
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Cyclisation of Cell Penetrating PDZ-Binding Peptides Directed to PSD95 [PDF]
, 2019 Excitatory glutamatergic neurotransmission via N-methyl-D-aspartate receptor (NMDAR) is critical for synaptic plasticity and survival of neurons. Excessive NMDAR activity, however can cause excitotoxicity and promote cell death, underlying a potential ...
Al-Nasir, J +4 more
core +2 more sources