Results 21 to 30 of about 55,585 (143)
Frontiers in Molecular Neuroscience, 2022 For decades, N-methyl-D-aspartate (NMDA) receptors have been known to play a critical role in the modulation of both acute and chronic pain. Of particular interest are NMDA receptors expressed in the superficial dorsal horn (SDH) of the spinal cord ...
Annemarie Dedek +3 more
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Journal of Venomous Animals and Toxins including Tropical Diseases, 2017 Background The N-methyl-D-aspartate (NMDA) receptors are glutamate receptors that play vital roles in central nervous system development and are involved in synaptic plasticity, which is an essential process for learning and memory.
Maleeha Waqar, Sidra Batool
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Mutations of N-Methyl-D-Aspartate Receptor Subunits in Epilepsy [PDF]
Neuroscience Bulletin, 2017 Epilepsy is one of the most common neurological diseases. Of all cases, 70%-80% are considered to be due to genetic factors. In recent years, a large number of genes have been identified as being involved in epilepsy. Among them, N-methyl-D-aspartate receptor (NMDAR) subunit-encoding genes represent a large proportion, suggesting an important role for ...
Xing-Xing Xu, Jianhong Luo
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Structural basis of subtype-selective competitive antagonism for GluN2C/2D-containing NMDA receptors
Nature Communications, 2020 Selectively inhibiting N-Methyl-D-aspartate receptors (NMDARs) containing the GluN2C/2D subunits has been challenging. Here, using electrophysiology and X-ray crystallography, authors show that compounds UBP791 and UBP1700 show over 40- and 50-fold ...
Jue Xiang Wang +11 more
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Nature Communications, 2018 N-methyl-d-aspartate-receptors (NMDARs) are glutamate receptors critical for synaptic transmission, plasticity, and cognition. Here, the authors look at four neurodevelopmental disease-related mutations of NMDAR, gaining insight into binding of Mg2+ and ...
Laura Fedele +5 more
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GRIN1 Mutations in Early-Onset Epileptic Encephalopathy
Pediatric Neurology Briefs, 2015 Investigators from Yokohama City University and other medical centers in Israel and Japan reported mutations on N-methyl-D-aspartate (NMDA) receptors subunit GRIN1 (GluN1) identified in patients with nonsyndromic intellectual disability and early-onset ...
Wenjuan Chen, Hongjie Yuan
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Biophysical Journal, 1995 Small volumes of N-Methyl-D-Aspartate (NMDA) and non-NMDA excitatory amino acid receptor agonists were applied to localized regions of the dendritic trees of lamprey spinal neurons along their medial-lateral axis to obtain a spatial map of glutamate receptor distribution.
Moore, L. E. +2 more
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The Role of N-Methyl D-Aspartate Receptors on Pain Transmission
Cukurova Medical Journal, 2012 Aim : In the experimental studies, NMDA (N-methyl-D-aspartate) receptors play important role in the mechanism of action among the drugs used for the treatment of pain.
Yasemin Gunes +3 more
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D-Amino Acids in the Nervous and Endocrine Systems
Scientifica, 2016 Amino acids are important components for peptides and proteins and act as signal transmitters. Only L-amino acids have been considered necessary in mammals, including humans. However, diverse D-amino acids, such as D-serine, D-aspartate, D-alanine, and D-
Yoshimitsu Kiriyama, Hiromi Nochi
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Anti-N-methyl-D-aspartate receptor encephalitis: three cases report and review of literature
Chinese Journal of Contemporary Neurology and Neurosurgery, 2014 Objective To study the clinical and laboratory features and diagnosis of the patient with anti-N-methyl-D-aspartate receptor (NMDAR) encephalitis.
Guan-en ZHOU, Zhong-ping AN
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