Results 21 to 30 of about 149,284 (337)

Structure-activity relationships for amino acid transmitter candidates acting at N-methyl-D-aspartate and quisqualate receptors

Journal of Neuroscience, 1990
Dose-response curves for activation of excitatory amino acid receptors on mouse embryonic hippocampal neurons in culture were recorded for 15 excitatory amino acids, including the L-isomers of glutamate, aspartate, and a family of endogenous sulfur amino
DK Patneau, M. Mayer
semanticscholar   +1 more source

N-methyl-D-aspartate receptors in the basolateral amygdala are required for both acquisition and expression of conditional fear in rats

Behavioral Neuroscience, 1996
Three experiments examined the effects of intra-amygdaloid infusions of an N-methyl-D-aspartate (NMDA) receptor antagonist, D,L-2-amino-5-phosphonovalerate (APV), on contextual fear conditioning in rats. In Experiment 1, APV infusion into the basolateral
Stephen Maren, G. Aharonov, D. L. Stote, M. Fanselow   +3 more
semanticscholar   +2 more sources

Spatial and temporal boundaries of NMDA receptor hypofunction leading to schizophrenia

npj Schizophrenia, 2017
The N-methyl-d-aspartate receptor hypofunction is one of the most prevalent models of schizophrenia. For example, healthy subjects treated with uncompetitive N-methyl-d-aspartate receptor antagonists elicit positive, negative, and cognitive-like symptoms
Kazu Nakazawa, Vivek Jeevakumar, Kazuhito Nakao   +2 more
doaj   +1 more source

Uses of magnesium sulfate in anesthesiology

Revista Médica del Hospital General de México, 2022
Introduction: Magnesium sulfate heptahydrate (MgSO4 7H2O) is a divalent cation, pharmacologically its mechanism has been as a reversible blocker of the N-methyl-D-aspartate receptor (NMDAR) and therefore has been proposed in the use of anesthesiology ...
Claudia I. Gutiérrez-Román, Orlando Carrillo-Torres, Emmanuel S. Pérez-Meléndez   +2 more
doaj   +1 more source

Modulatory effects mediated by metabotropic glutamate receptor 5 on lateral geniculate nucleus relay cells [PDF]

, 2005
[Abstract] Glutamate is thought to be the excitatory neurotransmitter in the lateral geniculate nucleus (LGN) of the cat, mediating visual transmission from the retina via ionotropic receptors of both d,l-α-amino-3-hydroxy-5-α-methyl-4 ...
Cudeiro, Javier, Labra, Carmen de, Rivadulla, Casto   +2 more
core   +2 more sources

Role of cortical N-methyl-D-aspartate receptors in auditory sensory memory and mismatch negativity generation: implications for schizophrenia.

Proceedings of the National Academy of Sciences of the United States of America, 1996
Working memory refers to the ability of the brain to store and manipulate information over brief time periods, ranging from seconds to minutes. As opposed to long-term memory, which is critically dependent upon hippocampal processing, critical substrates
D. Javitt, M. Steinschneider, C. E. Schroeder, J. Arezzo   +3 more
semanticscholar   +1 more source

Research progress of N⁃methyl⁃D⁃aspartate receptor GRIN2A gene variations and epilepsy

Chinese Journal of Contemporary Neurology and Neurosurgery, 2023
In recent years, with the rapid development of gene sequencing technology, a variety of epilepsy pathogenic genes have been discovered, among which GRIN2A gene variations encoding the neurotransmitter N⁃methyl⁃D⁃aspartate receptor (NMDAR) are closely ...
TANG Wei⁃ting, XIAO Bo
doaj   +1 more source

The effects of AMPA receptor blockade on resting magnetoencephalography recordings [PDF]

, 2017
The ionotropic N-methyl-D-aspartate and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors of the glutamatergic neurotransmitter system are of fundamental importance to healthy brain function.
Khalid, Hamandi, Muthukumaraswamy, Suresh D, Routley, Bethany, Singh, Krishna   +3 more
core   +1 more source

The effect of N-acetyl-aspartyl-glutamate and N-acetyl-aspartate on white matter oligodendrocytes [PDF]

, 2009
Elevations of the levels of N-acetyl-aspartyl-glutamate (NAAG) and N-acetyl-aspartate (NAA) are associated with myelin loss in the leucodystrophies Canavan's disease and Pelizaeus-Merzbacher-like disease. NAAG and NAA can activate and antagonize neuronal
A. Wade, Berger, Bergeron, Billups, Burlina, Bzdega, Chakraborty, Chatterton, D'Angelo, D. Attwell, Fenwick, Fields, Follett, Jakobs, Jane, K. Kolodziejczyk, Karadottir, Karadottir, Khwaja, Koenig, Kumar, K  rad  ttir, Li, Micu, N. B. Hamilton, Pliss, R. Karadottir, Rubin, Salter, Sartori, Sekiguchi, Tortella, Valivullah, Westbrook, Wevers, Wolf, Wroblewska   +36 more
core   +2 more sources

Role of N-methyl-D-aspartate receptors in action-based predictive coding deficits in schizophrenia [PDF]

, 2017
Published in final edited form as:Biol Psychiatry. 2017 March 15; 81(6): 514–524. doi:10.1016/j.biopsych.2016.06.019.BACKGROUND: Recent theoretical models of schizophrenia posit that dysfunction of the neural mechanisms subserving predictive coding ...
Ford, Judith M., Gunduz-Bruce, Handan, Jaeger, Judith, Kort, Naomi S., Krystal, John H., Mathalon, Daniel H., Reinhart, Robert M.G., Roach, Brian J.   +7 more
core   +1 more source