The Role of N-Methyl D-Aspartate Receptors on Pain Transmission
Çukurova Üniversitesi Tıp Fakültesi Dergisi, 2012 Aim : In the experimental studies, NMDA (N-methyl-D-aspartate) receptors play important role in the mechanism of action among the drugs used for the treatment of pain.
Yasemin Gunes +3 more
doaj
, 2016 NMDA receptors are ion channels activated by the neurotransmitter glutamate in the mammalian brain and are important in synaptic function and plasticity, but are also found in extrasynaptic locations and influence neuronal excitability.
Scheppach, Christian
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NYX-2925 Is a Novel NMDA Receptor-Specific Spirocyclic-beta-Lactam That Modulates Synaptic Plasticity Processes Associated with Learning and Memory [PDF]
, 2018 Background: N-methyl-D-aspartate receptors are one member of a family of ionotropic glutamate receptors that play a pivotal role in synaptic plasticity processes associated with learning and have become attractive therapeutic targets for diseases such as
Cearley, Cassia +6 more
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The prion protein regulates glutamate-mediated Ca2+ entry and mitochondrial Ca2+ accumulation in neurons [PDF]
, 2017 The cellular prion protein (PrPC) whose conformational misfolding leads to the production of deadly prions, has a still-unclarified cellular function despite decades of intensive research.
Bertoli, Alessandro +8 more
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Chronic brain inflammation leads to a decline in hippocampal NMDA-R1 receptors
Journal of Neuroinflammation, 2004 Background Neuroinflammation plays a prominent role in the progression of Alzheimer's disease and may be responsible for degeneration in vulnerable regions such as the hippocampus.
Hauss-Wegrzyniak Beatrice +3 more
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Serotonin Modulates Oscillations of the Membrane Potential in Isolated Spinal Neurons from Lampreys [PDF]
, 2002 Studies were performed on spinal neurons from lampreys isolated by an enzymatic/mechanical method using pronase. The effects of 100 µM serotonin (5-HT) on membrane potential oscillations induced by a variety of excitatory amino acids were studied.
Batueva, I. V. +4 more
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Neurotransmitters Drive Combinatorial Multistate Postsynaptic Density Networks [PDF]
, 2009 The mammalian postsynaptic density (PSD) comprises a complex collection of ~1100 proteins. Despite extensive knowledge of individual proteins, the overall organization of the PSD is poorly understood.
Choudhary, Jyoti S +8 more
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Anti-N-methyl-D-aspartate receptor encephalitis: one case report
Chinese Journal of Contemporary Neurology and Neurosurgery, 2015 DOI: 10.3969/j.issn.1672-6731.2015.12 ...
Ying CHEN +3 more
doaj
In vivo evidence for NMDA receptor mediated excitotoxicity in a murine genetic model of Huntington Disease [PDF]
, 2008 N-methyl-D-aspartate receptor (NMDAR) mediated excitotoxicity is implicated as a proximate cause of neurodegeneration in Huntington Disease (HD). However, this hypothesis has not been tested rigorously in vivo. NMDAR NR2B-subunits are the predominant NR2
Joe Tsien +4 more
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Direct Inhibition of N-Methyl-D-Aspartate (NMDA)-Receptor Function by Antiglaucomatous β-Antagonists
Journal of Pharmacological Sciences, 2008 In the present study, we investigated the direct effects of antiglaucoma drugs (timolol, betaxolol, pilocarpine, and latanoprost) on N-methyl-D-aspartate (NMDA)-receptor function using a Xenopus oocytes expression system and electrophysiological ...
Tatsuo Nagata +7 more
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