Results 71 to 80 of about 38,001 (122)
Proceedings of the National Academy of Sciences of the United States of America, 2000 The low density lipoprotein receptor-related protein (LRP) is an endocytic receptor that is a member of the low density lipoprotein receptor family. We report that the LRP ligand, activated alpha(2)-macroglobulin (alpha(2)M*), induces robust calcium ...
B. Bacskai +4 more
semanticscholar +1 more source
Dual Action of Memantine in Alzheimer Disease: A Hypothesis
Taiwanese Journal of Obstetrics & Gynecology, 2009 Objective: In this study, we proposed a hypothesis to explain the mechanisms of memantine action in treating Alzheimer disease (AD). Memantine may reduce the expression of amyloid precursor protein and tau protein, as well as acting as an antagonist of N-
Tzong-Yuan Wu, Chih-Ping Chen
doaj +1 more source
Proceedings of the National Academy of Sciences of the United States of America, 2004 Traumatic brain injury is a leading cause of mortality and morbidity among young people. For the last couple of decades, it was believed that excess stimulation of brain receptors for the excitatory neurotransmitter glutamate was a major cause of delayed
A. Biegon +5 more
semanticscholar +1 more source
A Comprehensive Review of the Ketamine Mechanism and Its Pleiotropic Effects [PDF]
المجلة العراقية للصيدلةObjective: In the world of anesthetics, ketamine is unique. Over thirty years ago, the substance was first used in therapeutic practice to act as a "mono-anesthetic," causing analgesia, forgetfulness, loss of consciousness, and immobility.
Taqwa B. Thanoon, Zeina Althanoon
doaj +1 more source
Effect of Alprazolam and Ketamine on Seizures Induced by Two Different Convulsants
Acta Medica, 1997 Effect of two anticonvulsants with different mechanism of action, i.e. alprazolam and ketamine, was tested in two types of seizure activity.
Josef Herink
doaj +1 more source
Multiple Routes for Glutamate Receptor Trafficking: Surface Diffusion and Membrane Traffic Cooperate to Bring Receptors to Synapses [PDF]
Science's STKE (electronic resource) : signal transduction
knowledge environment 327 (21/03/2006) 13, 2007 Trafficking of glutamate receptors into and out of synapses is critically involved in the plasticity of excitatory synaptic transmission. Endocytosis and exocytosis of receptors have initially been thought to account alone for this trafficking. However, membrane proteins also traffic through surface lateral diffusion in the plasma membrane. We describe
arxiv
Journal of Biological Chemistry, 2006 Alzheimer disease (AD) is a progressive, neurodegenerative disorder that leads to debilitating cognitive deficits. Although little is known about the early functional or ultrastructural changes associated with AD, it has been proposed that a stage of ...
Brent L. Kelly, Adriana Ferreira
semanticscholar +1 more source
Astrocytic NMDA Receptors Modulate the Dynamics of Continuous Attractors [PDF]
arXivNeuronal networking supports complex brain functions, with neurotransmitters facilitating communication through chemical synapses. The release probability of neurotransmitters varies and is influenced by pre-synaptic neuronal activity. Recent findings suggest that blocking astrocytic N-Methyl-D-Aspartate (NMDA) receptors reduces this variation. However,
arxiv
Anesthesiology, 2019 What We Already Know about This TopicPresynaptic N-methyl-D-aspartate receptors contribute to opioid tolerance and hyperalgesia as well as neuropathic painThe &agr;2&dgr;-1 protein subunit enhances presynaptic N-methyl-D-aspartate receptor activity What ...
M. Deng, Shaorui Chen, Hong Chen, H. Pan
semanticscholar +1 more source
Presynaptic NMDA receptors and spike timing-dependent long-term depression at cortical synapses
Frontiers in Synaptic Neuroscience, 2010 It has recently been discovered that some forms of timing-dependent long-term depression (t-LTD) require presynaptic N-methyl-D-aspartate (NMDA) receptors. In this review, we discuss the evidence for the presence of presynaptic NMDA receptors at cortical
Antonio Rodriguez Moreno +4 more
doaj +1 more source