Results 71 to 80 of about 148,087 (354)

RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease

Hepatology, EarlyView., 2022
RIPK3 dampens mitochondrial bioenergetics and lipid droplet dynamics in metabolic liver disease. Abstract Background and Aims Receptor‐interacting protein kinase 3 (RIPK3) mediates NAFLD progression, but its metabolic function is unclear. Here, we aimed to investigate the role of RIPK3 in modulating mitochondria function, coupled with lipid droplet (LD)
Marta B. Afonso, Tawhidul Islam, Julie Magusto, Ricardo Amorim, Véronique Lenoir, Rui F. Simões, José Teixeira, Liana C. Silva, Dominique Wendum, Isabelle Jéru, Corinne Vigouroux, Rui E. Castro, Paulo J. Oliveira, Carina Prip‐Buus, Vlad Ratziu, Jérémie Gautheron, Cecília M. P. Rodrigues   +16 more
wiley   +1 more source

Algebraic study of receptor-ligand systems: a dose-response analysis [PDF]

arXiv, 2022
The study of a receptor-ligand system generally relies on the analysis of its dose-response (or concentration-effect) curve, which quantifies the relation between ligand concentration and the biological effect (or cellular response) induced when binding its specific cell surface receptor.
arxiv  

N-methyl-D-aspartate receptors play important roles in acquisition and expression of the eyeblink conditioned response in glutamate receptor subunit delta2 mutant mice. [PDF]

, 2005
Classical eyeblink conditioning has been known to depend critically on the cerebellum. Apparently consistent with this, glutamate receptor subunit delta2 null mutant mice, which have serious morphological and functional deficiencies in the cerebellar ...
Fukunaga Satoshi, Kato Yoshiko, Kawahara Shigenori, Kirino Yutaka, Mishina Masayoshi, Mori Hisashi, Takatsuki Kanako   +6 more
core   +2 more sources

Molecular determinants of coordinated proton and zinc inhibition of N-methyl-D-aspartate NR1/NR2A receptors.

Proceedings of the National Academy of Sciences of the United States of America, 2000
Modulation of the N-methyl-d-aspartate (NMDA)-selective glutamate receptors by extracellular protons and Zn(2+) may play important roles during ischemia in the brain and during seizures.
C. Low, Fang Zheng, P. Lyuboslavsky, S. Traynelis   +3 more
semanticscholar   +1 more source

Bacterial‐Based Molecular Communication: Simulation of a Fixed and Receding Receiver Scenarios in Varied Viscosities and Environmental Conditions

Advanced Theory and Simulations, EarlyView.
This study presents a robust 3D simulation for BBMC, focusing on both fixed and receding receiver scenarios across various conditions. Key parameters such as D, Q, u, and d are tested at different values to assess the performance and reliability of BBMC in applications like drug delivery, addressing critical challenges in nanoscale communication with ...
Mustafa Ozan Duman, Ibrahim Isik, Esme Isik, Mehmet Bilal Er   +3 more
wiley   +1 more source

Method for identification of condition-associated public antigen receptor sequences [PDF]

eLife 2018;7:e33050, 2017
Diverse repertoires of hypervariable immunoglobulin receptors (TCR and BCR) recognize antigens in the adaptive immune system. The development of immunoglobulin receptor repertoire sequencing methods makes it possible to perform repertoire-wide disease association studies of antigen receptor sequences.
arxiv   +1 more source

Massage‐Mimicking Nanosheets Mechanically Reorganize Inter‐organelle Contacts to Restore Mitochondrial Functions in Parkinson's Disease

Advanced Science, EarlyView.
Parkinson's disease (PD) progression is aggravated by disrupted inter‐organelle contacts, which are influenced by mechanical forces. NanoMassage, 200 nm PEGylated black phosphorus nanosheets, deliver targeted mechanical stimulation to neural cells.
Tianqi Li, Liwen Huang, Chenxiao Guo, Jing Ren, Xi Chen, Yachu Ke, Zengyu Xun, Wenzhuo Hu, Yilin Qi, Heping Wang, Zhongying Gong, Xing‐Jie Liang, Xue Xue   +12 more
wiley   +1 more source

Multiple and Alternative Sites Make Tau Protein an Adaptable Sticky Surface for the SH3 Domain of Fyn Kinase

Angewandte Chemie, EarlyView.
An NMR‐based study, combined with computational, calorimetric and in‐cell FRET methods, sheds light on the complex recognition mechanism between the intrinsically disordered protein Tau and the SH3 domain of Fyn kinase, highlighting how the multiple binding sites present in Tau make the protein an adaptable recognition surface that can function even ...
Roberto Tira, Giulia Leo, Laura Prandini, Carlo Giorgio Barracchia, Mariapina D'Onofrio, Luca Mollica, Stefano Capaldi, Michael Assfalg, Francesca Munari   +8 more
wiley   +2 more sources

Regulation of Neuromodulator Receptor Efficacy - Implications for Whole-Neuron and Synaptic Plasticity [PDF]

Progress in Neurobiology 72(6), pp 399-415, April 2004, 2004
Membrane receptors for neuromodulators (NM) are highly regulated in their distribution and efficacy - a phenomenon which influences the individual cell's response to central signals of NM release. Even though NM receptor regulation is implicated in the pharmacological action of many drugs, and is also known to be influenced by various environmental ...
arxiv   +1 more source

Localization and interaction of N-methyl-D-aspartate and non-N-methyl-D-aspartate receptors of lamprey spinal neurons

Biophysical Journal, 1995
Small volumes of N-Methyl-D-Aspartate (NMDA) and non-NMDA excitatory amino acid receptor agonists were applied to localized regions of the dendritic trees of lamprey spinal neurons along their medial-lateral axis to obtain a spatial map of glutamate receptor distribution.
Moore, L. E., Buchanan, James T., Murphey, C. R.   +2 more
openaire   +3 more sources