Results 71 to 80 of about 155,151 (336)

Elevated Apolipoprotein E Expression in Hippocampal Microglia Drives Temporal Lobe Epilepsy Progression

Advanced Science, EarlyView.
In temporal lobe epilepsy, hippocampal APOE is markedly upregulated predominantly in microglia. APOE overexpression in microglia drives TLR4 and cGAS/STING‐dependent neuroinflammation, engages bidirectional crosstalk with neurons and astrocytes, increases neuronal excitability, and perturbs hippocampal lipid metabolism. These findings suggest that APOE‐
Jianwei Shi, Zesheng Li, Xin Sun, Yanfeng Yang, Yumin Luo, Ziang Song, Hengxin Dong, Lei Jin, Jing Xie, Yongzhi Shan, Guoguang Zhao   +10 more
wiley   +1 more source

Candidate glutamatergic and dopaminergic pathway gene variants do not influence Huntington’s disease motor onset [PDF]

, 2014
Huntington’s disease (HD) is a neurodegenerative disorder characterized by motor, cognitive, and behavioral disturbances. It is caused by the expansion of the HTT CAG repeat, which is the major determinant of age at onset (AO) of motor symptoms. Aberrant
Abramson, Ruth K., Alonso, Isabel, Ashizawa, Tetsuo, Ayuso, Carmen, Di Donato, Stefano, Di Pardo, Alba, Frank, Samuel, Frontali, Marina, Gellera, Cinzia, Gillis, Tammy, Gomez-Tortosa, Estrella, Gusella, James F., Harrison, Madaline B., Hayden, Michael R., Hersch, Steven M., Jones, Randi, Latourelle, Jeanne C., Lee, Jong-Min, Lucente, Diane, MacDonald, Marcy E., Marder, Karen, Margolis, Russell L., McCusker, Elizabeth, Morrison, Patrick J., Myers, Richard H., Mysore, Jayalakshmi S., Nance, Martha, Novelletto, Andrea, Ramos, Eliana Marisa, Rosas, Herminia D., Ross, Christopher A., Saint-Hilaire, Marie-Helene, Sequeiros, Jorge, Squitieri, Ferdinando, Suchowersky, Oksana, Trent, Ronald J., Zanko, Andrea   +36 more
core   +1 more source

Regulation of Dopamine D1 Receptor Trafficking and Desensitization by Oligomerization with Glutamate N-Methyl-D-aspartate Receptors*

Journal of Biological Chemistry, 2003
Activation of dopamine D1 receptors is critical for the generation of glutamate-induced long-term potentiation at corticostriatal synapses. In this study, we report that, in striatal neurons, D1 receptors are co-localized with N-methyl-d-aspartate (NMDA)
C. Fiorentini, F. Gardoni, P. Spano, M. di Luca, C. Missale   +4 more
semanticscholar   +1 more source

Onion‐Mitochondria Inhibit Lipopolysaccharide‐Induced Acute Lung Injury by Shaping Lung Macrophage Mitochondrial Function

Advanced Science, EarlyView.
Proposed model of orally administered onion mitochondria (O‐Mit) uptake by lung macrophages and fuse with macrophage mitochondria (M‐Mit). This fusion reprograms the metabolism of dysfunctional M‐Mit in lipopolysaccharide‐induced murine acute lung injury by modulating dynamin‐related protein 1 (DRP1) phosphorylation and cardiolipin peroxidation ...
Qingbo Xu, Yun Teng, Yinan Huang, Jingyao Mu, Lucy Teng, Hongjia Qian, Qiming Huang, Minmin Liu, Yi Zou, Lifeng Zhang, Michael L Merchant, Xiang Zhang, Jun Yan, Huang‐Ge Zhang   +13 more
wiley   +1 more source

Long-Term Treatment With Morphine Increases the D-Serine Content in the Rat Brain by Regulating the mRNA and Protein Expressions of Serine Racemase and D-Amino Acid Oxidase

Journal of Pharmacological Sciences, 2008
Recent studies indicate that an endogenous co-agonist for an N-methyl-D-aspartate (NMDA) receptor–related glycine site, D-serine, is synthesized by serine racemase and is metabolized by D-amino acid oxidase (DAO) and that acute treatment with morphine ...
Masanobu Yoshikawa, Takashi Shinomiya, Naoko Takayasu, Hideo Tsukamoto, Mitsuru Kawaguchi, Hiroyuki Kobayashi, Tetsuo Oka, Atsushi Hashimoto   +7 more
doaj   +1 more source

Conformational rearrangement of the NMDA receptor amino-terminal domain during activation and allosteric modulation

Nature Communications, 2021
N-Methyl-D-aspartate receptors (NMDARs) activation involves closure of the GluN1 and GluN2 subunit ligand binding domains, which is regulated allosterically by the amino-terminal domain (ATD).
Vojtech Vyklicky, Cherise Stanley, Chris Habrian, Ehud Y. Isacoff   +3 more
doaj   +1 more source

Triheteromeric NR1/NR2A/NR2B Receptors Constitute the Major N-Methyl-d-aspartate Receptor Population in Adult Hippocampal Synapses

Journal of Biological Chemistry, 2010
NMDA receptors (NMDARs), fundamental to learning and memory and implicated in certain neurological disorders, are heterotetrameric complexes composed of two NR1 and two NR2 subunits.
Claudia Rauner, G. Köhr
semanticscholar   +1 more source

Iron Overload Mediates the Differential Cell Fate of Astrocytes from Neurons and Its Regulatory Mechanisms in Ischemic Stroke

Advanced Science, EarlyView.
Upon ischemia/reperfusion‐induced iron overload condition, neurons and astrocytes exhibit similar oxidative stress changes but opposite alterations in endogenous antioxidant defense mechanisms, leading to divergent ferroptotic outcomes. The iron deposition and neuronal loss are increased within the perilesional cortex of stroke patients ...
Yi Guo, Yue Wang, Yong Ni, Bin Bo, Jinzhi He, Yongming Zhu, Aiping Qin, Xianyong Zhou, Huaping Du, Yuan Liu, Tianyao Wang, Yudu Li, Yibo Zhao, Zengai Chen, Zhipei Liang, Yao Li, Yuan Xu, Huiling Zhang   +17 more
wiley   +1 more source

Hippocampal Memory Recovery After Acute Stress: A Behavioral, Morphological and Molecular Study [PDF]

, 2018
Indexación: Scopus.Laboratory of Neuroplasticity and Neurogenetics, Department of Biochemistry and Molecular Biology, Faculty of Chemistry and Pharmaceutical Sciences, Universidad de Chile, Santiago, Chile, 2Laboratorio Farmacología del Comportamiento ...
Ana M. Avalos, Ana M. Avalos, Aníbal Pacheco, Esteban Aliaga, Felipe Antonio Olave, Felipe Ignacio Aguayo, Gabriela Díaz-Véliz, Gonzalo García-Rojo, Jenny Lucy Fiedler, José L. Ulloa, Luciano Román-Albasini, Macarena Tejos-Bravo, Paulina S. Rojas, Wladimir Corrales   +13 more
core   +5 more sources

Selective vulnerabilities of N-methyl-D-aspartate (NMDA) receptors during brain aging

Frontiers in Aging Neuroscience, 2010
N-methyl-D-aspartate (NMDA) receptors are present in high density within the cerebral cortex and hippocampus and play an important role in learning and memory.
Brenna L Brim, Siba R Das
doaj   +1 more source