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Nerve growth factor receptors in dementia [PDF]
TURKISH JOURNAL OF MEDICAL SCIENCES, 2015 Nerve growth factor (NGF) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate NGF receptor expression and release the truncated nerve growth factor receptor (TNGFR) to biological fluids.
Manoochehr Messripour +3 more
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Nerve growth factor binding domain of the nerve growth factor receptor. [PDF]
Proceedings of the National Academy of Sciences, 1991 A structural analysis of the rat low-affinity nerve growth factor (NGF) receptor was undertaken to define the NGF binding domain. Mutant NGF receptor DNA constructs were expressed in mouse fibroblasts or COS cells, and the ability of the mutant receptor to bind NGF was assayed.
Catherine M. Bitler +3 more
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Hidden receptors for nerve growth factor in PC12 cells [PDF]
European Journal of Biochemistry, 1983 The binding of nerve growth factor (NGF) to its receptors in PC12 cells was studied in two experimental conditions: (a) cell fixation with paraformaldehyde followed by permeabilization of the plasma membrane with methanol and (b) metabolic poisoning of living cells with sodium azide.
CATTANEO, ANTONINO +3 more
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Journal of Investigative Dermatology, 1994 Keratinocytes, a key cellular component both for homeostasis and pathophysiologic processes of the skin, secrete a number of cytokines and are stimulated by several growth factors. Nerve growth factor (NGF) is synthesized in the skin and basal keratinocytes express the low-affinity nerve growth factor receptor (NGF-R).
PINCELLI, Carlo +9 more
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Nerve growth factor and its receptor in schizophrenia
BBA Clinical, 2014 Promising studies suggest that defects in synaptic plasticity detected in schizophrenia may be linked to neurodevelopmental and neurodegenerative abnormalities and contribute to disease-associated cognitive impairment. We aimed to clarify the role of the synaptic plasticity regulatory proteins, nerve growth factor (NGF) and its receptor (NGFR) in the ...
Zakharyan, Roksana +3 more
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Binding of Nerve Growth Factor Receptor in Sympathetic Ganglia [PDF]
Proceedings of the National Academy of Sciences, 1973 125 I-Labeled nerve growth factor binds to membrane preparations from superior cervical ganglia of rabbit in a specific fashion indicative of an interaction with the physiological receptor. Of various tissues examined, binding was observed only in the superior cervical ganglia, a presumed target organ of nerve growth factor ...
Lloyd A. Greene +3 more
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Nerve Growth and Expression of Receptors for Nerve Growth Factor in Tumors of Melanocyte Origin
Journal of Investigative Dermatology, 1991 Nerve growth factor (NGF) stimulates growth and differentiation of sensory and sympathetic neurons. It is not known what role NGF plays in melanoma development, but nevus and malignant melanoma cells express NGF-receptor (NGF-R). We counted nerve fibers within melanocytic nevi, primary cutaneous melanomas, and cutaneous melanoma metastases using a ...
Heike Magiera +2 more
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Distribution of neuronal receptors for nerve growth factor in the rat [PDF]
The Journal of Neuroscience, 1986 To survey the distribution of neuronal receptors for NGF, sections of the rat brain, spinal cord, and peripheral ganglia were incubated in vitro with radioiodinated NGF and examined by autoradiography. NGF binds selectively with high affinity to most sympathetic neurons and many primary sensory neurons together with their intraspinal or intramedullary ...
V. M. K. Verge Issa +2 more
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Nerve Growth Factor Receptor-Mediated Gene Transfer
Molecular Therapy, 2004 One obstacle to effective gene therapies for neurological disorders lies in the cell-type diversity of the nervous system, making it difficult to direct gene delivery vectors to specific types of cells. To meet this challenge, we have developed a recombinant peptide-based gene delivery vector that targets nerve growth factor (NGF) receptors.
Ma, N. +7 more
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Nerve Growth Factor Receptors in the Peripubertal Rat Ovary [PDF]
Molecular Endocrinology, 1991 We previously demonstrated that the immature rat ovary synthesizes nerve growth factor (NGF), and that interference of NGF actions by immunoneutralization during neonatal life prevents development of the ovarian sympathetic innervation and delays follicular maturation. Since the actions of NGF are exerted via binding to specific cell surface receptors,
Ying Jun Ma +4 more
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