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Nerve growth factor receptors in dementia [PDF]
TURKISH JOURNAL OF MEDICAL SCIENCES, 2015 Nerve growth factor (NGF) promotes the survival and differentiation of sensory and sympathetic neurons. Several studies have found that certain neuropathological factors stimulate NGF receptor expression and release the truncated nerve growth factor receptor (TNGFR) to biological fluids.
Manoochehr Messripour +3 more
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Targeting nerve growth factor: an Achilles’ heel for tumors? [PDF]
Journal for ImmunoTherapy of CancerA tumor’s ability to attract innervation is a critical factor in tumor progression and immune escape, with the sympathetic nervous system playing a major role.
Elizabeth Repasky, Hemn Mohammadpour
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Cell Communication and Signaling, 2022 Plain English summary Ceramide and sphingomyelin reportedly are important both for differentiation of nerve cells and for their death. We studied PC12 cells, which can differentiate into neuron-like cells in the presence of nerve growth factor and cells ...
Terri Kagan +3 more
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The effects of painless nerve growth factor on human microglia polarization
Frontiers in Cellular Neuroscience, 2022 Previous studies in the rat suggest that microglial cells represent a potential druggable target for nerve growth factor (NGF) in the brain. The painless human Nerve Growth Factor (hNGFp) is a recombinant mutated form of human nerve growth factor (hNGF ...
Lucia Lisi +8 more
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Exposure to nerve growth factor worsens nephrotoxic effect induced by Cyclosporine A in HK-2 cells. [PDF]
PLoS ONE, 2013 Nerve growth factor is a neurotrophin that promotes cell growth, differentiation, survival and death through two different receptors: TrkA(NTR) and p75(NTR).
Donatella Vizza +8 more
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Frontiers in Cell and Developmental Biology, 2021 Triple-negative breast cancer is a heterogeneous disease that still lacks specific therapeutic approaches. The identification of new biomarkers, predictive of the disease’s aggressiveness and pharmacological response, is a challenge for a more tailored ...
Marzia Di Donato +5 more
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Nerve growth factor in muscle afferent neurons of peripheral artery disease and autonomic function
Neural Regeneration Research, 2021 In peripheral artery disease patients, the blood supply directed to the lower limbs is reduced. This results in severe limb ischemia and thereby enhances pain sensitivity in lower limbs.
Lu Qin, Jianhua Li
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Diagnostics, 2021 Congenital diaphragm hernia (CDH) is a congenital disease that occurs during prenatal development. Although the morbidity and mortality rate is rather significant, the pathogenesis of CDH has been studied insignificantly due to the decreased ...
Ricards Kaulins +3 more
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Nerve growth factor binding domain of the nerve growth factor receptor. [PDF]
Proceedings of the National Academy of Sciences, 1991 A structural analysis of the rat low-affinity nerve growth factor (NGF) receptor was undertaken to define the NGF binding domain. Mutant NGF receptor DNA constructs were expressed in mouse fibroblasts or COS cells, and the ability of the mutant receptor to bind NGF was assayed.
Catherine M. Bitler +3 more
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Molecules, 2023 Prion protein peptide (PrP) has demonstrated neurotoxicity in brain cells, resulting in the progression of prion diseases with spongiform degenerative, amyloidogenic, and aggregative properties.
Sokho Kim, Jihye Choi, Jungkee Kwon
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