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International Journal of Neuroscience, 1985
Nerve growth factor is a polypeptide hormone that is required for the normal growth and development of the embryonic sensory and sympathetic nervous systems. On these cells, there are two different receptors for the nerve growth factor. Recently, these receptors have been isolated from three cell types and shown to have essentially the same binding ...
R W, Stach +3 more
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Nerve growth factor is a polypeptide hormone that is required for the normal growth and development of the embryonic sensory and sympathetic nervous systems. On these cells, there are two different receptors for the nerve growth factor. Recently, these receptors have been isolated from three cell types and shown to have essentially the same binding ...
R W, Stach +3 more
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The nerve growth factor family of receptors
Trends in Neurosciences, 1992The neurotrophins, of which nerve growth factor (NGF) is the best known example, support the survival and differentiation of chick embryo sensory neurons at extremely low concentrations, 10(-12) M or less. These same neurons display two different classes of neurotrophin receptors with dissociation constants of 10(-11) M and 10(-9) M, respectively ...
S O, Meakin, E M, Shooter
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Receptors for Nerve Growth Factor
1993Publisher Summary This chapter discusses the two receptors for nerve growth factor (NGF)—namely, (1) the low-affinity NGF receptor and (2) the product of the proto-oncogene trk . It also reviews the way they were originally identified and the structural and functional features of the two receptors.
M V, Chao, D S, Battleman, M, Benedetti
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THE RECEPTORS FOR NERVE GROWTH FACTOR AND OTHER NEUROTROPHINS
Annual Review of Biochemistry, 1993OVERVIEW .. . . . . . . . . . .. . .. . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 823 HISTORICAL ASPECTS . . . . . . . .. . . . . . . . . .. . . . . . . . . . .. . . . . . . . 825 MOLECULAR PROPERTIES . . . . . . . . . . . . . . . . ... . . . . .. . . .... . . . 827 Low-Molecular-Weight Receptor (LNGFR; p75) . l.:' . • . . . . . . . . . .
S, Raffioni, R A, Bradshaw, S E, Buxser
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Regulation of the Synthesis of Nerve Growth Factor and Nerve Growth Factor Receptor
1988The importance of Nerve Growth Factor (NGF) for the development and the maintenance of differentiated properties of peripheral sympathetic and neural crest- derived sensory neurons as well as for basal forebrain cholinergic neurons is well established (cf Levi-Montalcini & Angeletti, 1968; Greene & Shooter, 1980; Thoenen & Barde, 1980; Thoenen et al ...
R. Heumann +7 more
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Nerve Growth Factor Receptors and Signaling in Breast Cancer
Current Cancer Drug Targets, 2004Nerve growth factor (NGF) has long been known for its effects on neuronal cell survival and differentiation. This prototypical neurotrophic factor stimulates neurons through two distinct classes of membrane receptors: the TrkA tyrosine kinase receptor, and the tumor necrosis factor receptor family member p75NTR, also known as the common neurotrophin ...
Dollé, Laurent +5 more
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European Journal of Oral Sciences, 2012
Nerve growth factor (NGF) is a pluripotent mediator that is present in a range of human tissues. Nerve growth factor was originally considered important only in neuronal homeostasis and pathophysiology, but later it was also implicated in the pathophysiology of inflammation, epithelial differentiation, and wound healing. In this study, the distribution
Elsebeth P, Naesse +4 more
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Nerve growth factor (NGF) is a pluripotent mediator that is present in a range of human tissues. Nerve growth factor was originally considered important only in neuronal homeostasis and pathophysiology, but later it was also implicated in the pathophysiology of inflammation, epithelial differentiation, and wound healing. In this study, the distribution
Elsebeth P, Naesse +4 more
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Nerve growth factor and nerve growth factor receptors in respiratory syncytial virus-infected lungs
American Journal of Physiology-Lung Cellular and Molecular Physiology, 2002Nerve growth factor (NGF) controls sensorineural development and responsiveness and modulates immunoinflammatory reactions. Respiratory syncytial virus (RSV) potentiates the proinflammatory effects of sensory nerves in rat airways by upregulating the substance P receptor, neurokinin 1 (NK1).
Chengping, Hu +4 more
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Epidermal growth factor receptor ≠ nerve growth factor
Neurobiology of Aging, 1989I am perplexed by the authors' complete lack of definition of neurotrophic factors. The agents Butcher and Woolf want to blame are neurite promoting factors, not neurotrophic factors. Treatment of Alzheimer's disease with NGF antagonists might instead exacerbate the death of both basal forebrain neurons and their cortical target neurons, accelerating ...
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