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The nerve growth factor/tumor necrosis factor receptor family
Journal of Leukocyte Biology, 1996Abstract Receptors in the nerve growth factor/tumor necrosis factor receptor family are characterized by the presence of cysteine-rich motifs of ~40 amino acids in the extracellular domain. The ligands are type II transmembrane proteins with β-strands that form a jelly-roll β-sandwich.
Lotz, Martin +3 more
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Tissue Localization of Nerve Growth Factor and Nerve Growth Factor Receptors
1991The pioneering investigations of Levi-Montalcini and coworkers established that nerve growth factor (NGF) is an important physiological regulator of neurons of the peripheral nervous system. No doubt in part because of the dramatic and specific effects on the sympathetic and sensory nervous system resulting from immunochemically depriving rodents of ...
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The Membrane Receptor for Nerve Growth Factor
1991Receptors for mammalian growth factors are integral membrane proteins designed to have multiple functions for communicating with other cells and for intracellular signal transduction. These cell surface proteins have binding sites for the ligand that face the external environment and also an effector site that generates a biological signal within the ...
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The expression of growth factor receptors during nerve regeneration
Restorative Neurology and Neuroscience, 1990Growth factors and their receptors play a central role in the regulation of normal and injury-induced regenerative cell growth. In this article we review the data on the expression of growth factor receptors for β-nerve growth factor, platelet-derived growth factor and serum transferrin during regeneration following peripheral nerve injury.
Raivich, G. +3 more
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Nerve growth factor: two receptors, multiple functions
BioEssays, 1998Nerve growth factor (NGF) was characterized over 4 decades ago, and like the other neurotrophins subsequently discovered, it is best known for its trophic role, including the prevention of programmed cell death in specific populations of neurones in the peripheral nervous system. This property can be accounted for by the activation of a tyrosine kinase
Frade, J. M., Barde, Y. A.
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Acute Regulation of the Epidermal Growth Factor Receptor in Response to Nerve Growth Factor
Journal of Neurochemistry, 1991Abstract: PC12 cells possess specific receptors for both nerve growth factor and epidermal growth factor, and by an unknown mechanism, nerve growth factor is able to attenuate the propagation of a mitogenic response to epidermal growth factor.
A B, Brown, G, Carpenter
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Nerve growth factor and its receptors in asthma and inflammation
European Journal of Pharmacology, 2004Nerve growth factor (NGF) is a high molecular weight peptide that belongs to the neurotrophin family. It is synthesized by various structural and inflammatory cells and activates two types of receptors, the TrkA (tropomyosin-receptor kinase A) receptor and the p75(NTR) receptor, in the death receptor family. NGF was first studied for its essential role
Nelly, Frossard +2 more
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Peripheral nerve regeneration: Role of growth factors and their receptors
International Journal of Developmental Neuroscience, 1993AbstractGrowth factors play a central role in the regulation of normal and injury‐induced regenerative cell growth. The purpose of this article is to summarize the available data on the expression of different growth factors and their receptors in the injured peripheral nervous system and to discuss their possible role in promoting peripheral nerve ...
G, Raivich, G W, Kreutzberg
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Nicotine stimulation of nerve growth factor receptor expression
Life Sciences, 1994Previous studies have suggested that nicotine may have beneficial actions in neurodegenerative disease models. The purpose of the experiments described in this study was to determine whether the long lasting and beneficial effects of nicotine observed previously could be expressed through actions upon nerve growth factor (NGF) receptors.
A V, Terry, M S, Clarke
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Nerve Growth Factor Synthesis and Nerve Growth Factor Receptor Expression in Neural Development
1991Publisher Summary This chapter describes nerve growth factor (NGF) in the context of the neurotrophic theory. It also discusses its implications for understanding the molecular basis of neuron–target interactions in the developing nervous system. Since its discovery, NGF has been the prototype of a class of proteins termed “neurotrophic factors” that
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