Results 61 to 70 of about 205,915 (263)

Computational modelling of cancerous mutations in the EGFR/ERK signalling pathway [PDF]

, 2009
This article has been made available through the Brunel Open Access Publishing Fund - Copyright @ 2009 Orton et al.BACKGROUND: The Epidermal Growth Factor Receptor (EGFR) activated Extracellular-signal Regulated Kinase (ERK) pathway is a critical cell ...
Amelie Gormand, B Schoeberl, BN Kholodenko, BR Voldborg, C Dong, CJ Wikstrand, CY Huang, David R Gilbert, DK Moscatello, E Douville, FA Brightman, GEP Box, H Davies, HS Huang, J Pinney, JE Ferrell Jr, JL Bos, JS Oliveira, KS Brown, L Gao, M Calder, M Hucka, MH Schmidt, Michiel E Adriaens, N Chabrier, Oliver E Sturm, PA Humphrey, PA Humphrey, RD York, Richard J Orton, RJ Orton, RJ Orton, S Corbalan-Garcia, S Hoops, S Kao, S Sasagawa, S Traverse, S Traverse, S Yoon, SB Waters, SD Santos, SH Bigner, TA Libermann, V De Falco, Walter Kolch, WJ Langlois, WR Burack, YH Xu, YR Chen   +48 more
core   +3 more sources

Investigation of Solid‐Solution Phase Formation in AlCuNiSi Medium Entropy Alloys and its Effect on Microstructural, Thermal, and Microhardness Properties

Advanced Engineering Materials, EarlyView.
This study focuses on synthesizing equiatomic AlCuNiSi medium‐entropy alloys using mechanical alloying for advanced industrial applications. Continuous milling leads to grain refinement and the formation of stable BCC/FCC solid‐solution phases, resulting in enhanced mechanical properties. A unique Si‐rich solid‐solution phase is observed, which did not
Mustafa Okumuş, Mehmet Emin Demir, Celal Onat   +2 more
wiley   +1 more source

Identification of a conserved protein motif in a group of growth factor receptors [PDF]

, 1990
Residues 370–383 (helix C) of the human nerve growth factor receptor (NGF-R) are highly similar to the sequence of the 14 residue wasp toxin, mastoparan.
Feinstein, Douglas L., Larhammar, Dan
core   +1 more source

Enhanced Mechanical Properties of Injectable Chitosan–Guar Gum Hydrogel Reinforced with Bacterial Cellulose Nanofibers for Tissue Engineering Applications

Advanced Engineering Materials, EarlyView.
This study presents the development and characterization of injectable nanocomposite hydrogels based on N‐succinyl chitosan, oxidized guar gum, and bacterial cellulose nanofibers. Emphasizing enhanced mechanical properties and biocompatibility, the hydrogels exhibit fast gelation, improved structural integrity, and reduced swelling. Their potential for
Raimundo Nonato Fernandes Moreira Filho, Pascale Chevallier, Silvia Rodriguez Fernandez, Maud Viallon, Matheus Xavier de Oliveira, Ana Lorena de Brito Soares, Diego Mantovani, Judith Pessoa de Andrade Feitosa, Rodrigo Silveira Vieira   +8 more
wiley   +1 more source

Static Recrystallization Simulation of Interstitial Free‐Steel by Coupling Multi‐Phase‐Field and Crystal Plasticity Model Considering Dislocation Density Distribution

Advanced Engineering Materials, EarlyView.
This study models static recrystallization in interstitial free‐steel using coupled crystal plasticity and phase‐field simulations. The method directly links heterogeneous dislocation density to nucleation site prediction, eliminating reliance on empirical assumptions.
Alireza Rezvani, Ramin Ebrahimi, Ebad Bagherpour   +2 more
wiley   +1 more source

TGF beta type II receptor signaling controls Schwann cell death and proliferation in developing nerves [PDF]

, 2006
During development, Schwann cell numbers are precisely adjusted to match the number of axons. It is essentially unknown which growth factors or receptors carry out this important control in vivo.
D'Antonio, M, Droggiti, A, Feltri, ML, Jessen, KR, Mirsky, R, Roes, J, Wrabetz, L   +6 more
core  

Ras p21 protein promotes survival and fiber outgrowth of cultured embryonic neurons [PDF]

, 1989
Although evidence obtained with the PC12 cell line has suggested a role for the ras oncogene proteins in the signal transduction of nerve growth factor-mediated fiber outgrowth, little is known about the signal transduction mechanisms involved in the ...
Barde, Y. A., Borasio, Gian Domenico, Heumann, R., John, J., Sendtner, M., Wittinghofer, A.   +5 more
core   +2 more sources

Profilometry‐Based Indentation Plastometry Testing of Tungsten at High Temperature

Advanced Engineering Materials, EarlyView.
Profilometry‐based indentation plastometry (PIP) allows extraction of stress‐strain curves from indent profiles. Tungsten is of industrial interest but is brittle at room temperature. It does plastically deform at higher temperatures. Excellent agreement is obtained between the two techniques in this regime, but PIP also gives plasticity ...
James Rees Miller, Philip John McKeown, Hillary Qiu, Trevor William Clyne   +3 more
wiley   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

Residual Stress States in Microstructurally Graded PBF–LB/M Austenitic Steel Components

Advanced Engineering Materials, EarlyView.
This study examines microstructurally graded 316L rectangular tube profiles fabricated via PBF–LB/M using a dual‐laser system. A 1 kW top‐hat and a 400 W Gaussian laser create distinct grain sizes and crystallographic texture. Mechanical properties are linked to microstructural evolution driven by processing conditions.
Nico Möller, Florian Loebich, Thomas Wegener, Julia Richter, Jens Gibmeier, Thomas Niendorf   +5 more
wiley   +1 more source