Results 11 to 20 of about 296,111 (290)

Neurotransmitter Specific, Cellular-Resolution Functional Brain Mapping Using Receptor Coated Nanoparticles: Assessment of the Possibility. [PDF]

, 2015
Receptor coated resonant nanoparticles and quantum dots are proposed to provide a cellular-level resolution image of neural activities inside the brain. The functionalized nanoparticles and quantum dots in this approach will selectively bind to different
Forati, Ebrahim, Head, Brian, Ray, Supriyo, Sabouni, Abas, Schoen, Christian, Sievenpiper, Dan   +5 more
core   +9 more sources

Central nervous system interaction and crosstalk between nAChRs and other ionotropic and metabotropic neurotransmitter receptors

Pharmacological Research, 2023
Neuronal nicotinic acetylcholine receptors (nAChRs) are widely distributed in both the peripheral and the central nervous systems. nAChRs exert a crucial modulatory influence on several brain biological processes; they are involved in a variety of ...
Federica Bono, Chiara Fiorentini, Veronica Mutti, Zaira Tomasoni, Giulia Sbrini, Hanna Trebesova, Mario Marchi, Massimo Grilli, Cristina Missale   +8 more
doaj   +1 more source

Positive allosteric modulators of the a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptor [PDF]

, 2010
L-glutamate is the major excitatory neurotransmitter in the mammalian central nervous system (CNS) and plays a fundamental role in the control of motor function, cognition and mood.
Grove, Simon J .A., Jamieson, Craig, Maclean, John K. F., Morrow, John A., Rankovic, Zoran   +4 more
core   +1 more source

Organisational and neuromodulatory underpinnings of structural-functional connectivity decoupling in patients with Parkinson’s disease

Communications Biology, 2021
Zarkali et al. identify two organizational gradients to structural-functional connectivity decoupling in Parkinson’s disease and relate spatial patterns of decoupling to the expression of neurotransmitter receptors.
Angeliki Zarkali, Peter McColgan, Louise-Ann Leyland, Andrew J. Lees, Geraint Rees, Rimona S. Weil   +5 more
doaj   +1 more source

Determining the neurotransmitter concentration profile at active synapses [PDF]

, 2009
Establishing the temporal and concentration profiles of neurotransmitters during synaptic release is an essential step towards understanding the basic properties of inter-neuronal communication in the central nervous system.
A Barberis, A Scimemi, A Tao, A Triller, AE Spruce, AG Ogston, AI Gulyas, AM Aravanis, Annalisa Scimemi, AV Hill, B Barbour, B Ceccarelli, B Granseth, B Katz, C Auger, C Nicholson, C Nicholson, C Nicholson, C Racca, D Colquhoun, D Colquhoun, D Sulzer, DA Rusakov, DE Bergles, DM Kullmann, DR Copenhagen, E Betzig, E Neher, E Sykova, EL Botvinick, EN Pothos, EP Huang, F Asztely, F Pouille, G Brasnjo, G Liu, G Szapiro, G Tong, GH Acheson, GH Patterson, H Korn, H Korn, H Shroff, HC Hartzell, IM Raman, J Balaji, J Castillo Del, J Hrabe, J Matthews-Bellinger, J Szabadics, JC Eccles, JC Eccles, JC Eccles, JD Clements, JE Heuser, JH Singer, JI Wadiche, JI Wadiche, JJ Celentano, JM Bekkers, JM Christie, JM Fernandez, JR Stiles, JS Diamond, JS Diamond, JS Diamond, JW Mozrzymas, JW Mozrzymas, K Belaya, K Krnjevic, K Luby-Phelps, K Zheng, KA Foster, KE Sorra, KL Magleby, KM Franks, KP Lehre, L He, L Tao, LG Longsworth, LM Levy, LM Wahl, LP Savtchenko, LS Overstreet, M Beato, M Beato, M Beato, MA Medina, Marco Beato, MI Banks, MJ Higley, MV Jones, MY Min, N Arnth-Jensen, N Harata, N Riveros, NC Harata, O Prange, P Fatt, P Fatt, P Legendre, PJ Kruk, PM Burger, Q Zhang, Q Zhang, R Ando, R Conti, R Renden, R Ventura, RG Thorne, RH Chow, RM Wightman, RW Daniels, RY Tsien, S Habuchi, S Hrabetova, S Manley, S Namiki, S Okumoto, S Takamori, SA Hires, SJ Pitt, SP Gandhi, SW Kuffler, SY Breusegem, T Lu, T Schikorski, T Schikorski, TA Nielsen, TG Allen, TG Banke, TG Oertner, TM Bartol Jr, V Burzomato, VA Levin, W Almers, W Lu, X Chen, XS Wu, Y Dehnes, Y Takumi, YH Huang, Z Nusser, Z Petrasek, Z Petrasek   +144 more
core   +2 more sources

Neurotransmitter receptors on microglia [PDF]

Stroke and Vascular Neurology, 2016
As the resident immune cells in the central nervous system, microglia have long been hypothesised to promote neuroinflammation and exacerbate neurotoxicity. However, this traditional view has undergone recent revision as evidence has accumulated that microglia exert beneficial and detrimental effects depending on activation status, polarisation ...
Liu, Huan, Leak, Rehana K, Hu, Xiaoming
openaire   +2 more sources

Competition for synaptic building blocks shapes synaptic plasticity

eLife, 2018
Changes in the efficacies of synapses are thought to be the neurobiological basis of learning and memory. The efficacy of a synapse depends on its current number of neurotransmitter receptors. Recent experiments have shown that these receptors are highly
Jochen Triesch, Anh Duong Vo, Anne-Sophie Hafner   +2 more
doaj   +1 more source

Synaptic Neurotransmitter-Gated Receptors [PDF]

Cold Spring Harbor Perspectives in Biology, 2012
Since the discovery of the major excitatory and inhibitory neurotransmitters and their receptors in the brain, many have deliberated over their likely structures and how these may relate to function. This was initially satisfied by the determination of the first amino acid sequences of the Cys-loop receptors that recognized acetylcholine, serotonin ...
Trevor G, Smart, Pierre, Paoletti
openaire   +2 more sources

Two Players in the Field: Hierarchical Model of Interaction between the Dopamine and Acetylcholine Signaling Systems in the Striatum

Biomedicines, 2021
Tight interactions exist between dopamine and acetylcholine signaling in the striatum. Dopaminergic neurons express muscarinic and nicotinic receptors, and cholinergic interneurons express dopamine receptors.
Jaromir Myslivecek
doaj   +1 more source

A receptor-based analysis of local ecosystems in the human brain. [PDF]

, 2017
BackgroundAs a complex system, the brain is a self-organizing entity that depends on local interactions among cells. Its regions (anatomically defined nuclei and areas) can be conceptualized as cellular ecosystems, but the similarity of their functional ...
Janušonis, Skirmantas
core   +1 more source