Mechanism of Allosteric Modulation of the Cys-loop Receptors
Pharmaceuticals, 2010 The cys-loop receptor family is a major family of neurotransmitter-operated ion channels. They play important roles in fast synaptic transmission, controlling neuronal excitability, and brain function.
Paul Whiteaker +2 more
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Synaptic transmission as a cooperative phenomenon in confined systems [PDF]
, 2017 In this review paper, the theory of synaptic transmission (ST) was developed and discussed. We used the hypothesis of isomorphism between: (a) the cooperative behavior of mediators --- acetylcholine molecules (ACh) and cholinoreceptors in a synaptic ...
Chalyi, A. V. +2 more
core +2 more sources
Mechanism for neurotransmitter-receptor matching [PDF]
Proceedings of the National Academy of Sciences, 2020 SignificanceNeurotransmitter switching generally involves replacement of an excitatory transmitter with an inhibitory transmitter or vice versa and has been linked to changes in animal behavior. There are corresponding switches in postsynaptic receptors that enable continued function of the circuit, but the mechanism by which receptor expression is ...
Dena R. Hammond-Weinberger +3 more
openaire +4 more sources
Cancer and neurotransmitter receptors
Chinese Medical Journal. In recent years, growing evidence indicates that the nervous system plays an indispensable role in tumor development and metastasis. Elucidating crosstalk between the nervous system and tumor progression has thrived as a hot topic and a new direction ...
Xiaoqiang Wang +4 more
doaj +1 more source
Glutamate at the Vertebrate Neuromuscular Junction: From Modulation to Neurotransmission
Cells, 2019 Although acetylcholine is the major neurotransmitter operating at the skeletal neuromuscular junction of many invertebrates and of vertebrates, glutamate participates in modulating cholinergic transmission and plastic changes in the last.
Maria Nicol Colombo, Maura Francolini
doaj +1 more source
Opioids and Their Receptors: Present and Emerging Concepts in Opioid Drug Discovery II
Molecules, 2022 A few neurotransmitter systems have fascinated the research community, as muchas the opioid system (i.e., opioid ligands and their receptors) [...]
Richard M. Van Rijn, Mariana Spetea
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Could dopamine agonists aid in drug development for anorexia nervosa? [PDF]
, 2014 Anorexia nervosa is a severe psychiatric disorder most commonly starting during the teenage-years and associated with food refusal and low body weight. Typically there is a loss of menses, intense fear of gaining weight, and an often delusional quality ...
Frank, Guido KW
core +2 more sources
Transcriptome of the female synganglion of the black-legged tick Ixodes scapularis (Acari: Ixodidae) with comparison between Illumina and 454 systems. [PDF]
PLoS ONE, 2014 Illumina and 454 pyrosequencing were used to characterize genes from the synganglion of female Ixodes scapularis. GO term searching success for biological processes was similar for samples sequenced by both methods.
Noble Egekwu +3 more
doaj +1 more source
Ubiquitination of Neurotransmitter Receptors and Postsynaptic Scaffolding Proteins
Neural Plasticity, 2013 The human brain is made up of an extensive network of neurons that communicate by forming specialized connections called synapses. The amount, location, and dynamic turnover of synaptic proteins, including neurotransmitter receptors and synaptic ...
Amy W. Lin, Heng-Ye Man
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Altered expression of genes encoding neurotransmitter receptors in GnRH neurons of proestrous mice
Frontiers in Cellular Neuroscience, 2016 Gonadotropin-releasing hormone (GnRH) neurons play a key role in the central regulation of reproduction. In proestrous female mice, estradiol triggers the pre-ovulatory GnRH surge, however, its impact on the expression of neurotransmitter receptor genes ...
Csaba Vastagh +4 more
doaj +1 more source