Results 101 to 110 of about 114,328 (209)
Computational modeling of spike generation in serotonergic neurons of the dorsal raphe nucleu [PDF]
, 2012 We consider here a single-compartment model of these neurons which is capable of describing many of the known features of spike generation, particularly the slow rhythmic pacemaking activity often observed in these cells in a variety of species. Included
Penington, Nicholas J. +1 more
core
Structural conservation of Notch receptors and ligands
Seminars in Cell & Developmental Biology, 1998 The Notch signalling pathway is an evolutionarily conserved cell-to-cell communication system utilized multiple times and in many tissues during development. The outcome of an interaction between Notch and its ligands is highly influenced by factors both extrinsic and intrinsic to Notch expressing cells, suggesting that Notch functions either directly ...
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Notch receptor expression in human brain arteriovenous malformations
Journal of Cellular and Molecular Medicine, 2015 AbstractThe roles of the Notch pathway proteins in normal adult vascular physiology and the pathogenesis of brain arteriovenous malformations are not well‐understood. Notch 1 and 4 have been detected in human and mutant mice vascular malformations respectively.
Hill-Felberg, Sandra +3 more
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eLife, 2018 The correct establishment and maintenance of unidirectional Notch signaling are critical for the homeostasis of various stem cell lineages. However, the molecular mechanisms that prevent cell-autonomous ectopic Notch signaling activation and deleterious ...
Bo Li +6 more
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, 2016 Angiogenesis involves the formation of new blood vessels by sprouting or splitting of existing blood vessels. During sprouting, a highly motile type of endothelial cell, called the tip cell, migrates from the blood vessels followed by stalk cells, an ...
Dallinga, Marchien G. +5 more
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NOTCH3 inactivation increases triple negative breast cancer sensitivity to gefitinib by promoting EGFR tyrosine dephosphorylation and its intracellular arrest. [PDF]
, 2018 Notch dysregulation has been implicated in numerous tumors, including triple-negative breast cancer (TNBC), which is the breast cancer subtype with the worst clinical outcome.
Bellavia, Diana +14 more
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Signal Processing during Developmental Multicellular Patterning [PDF]
, 2008 Developing design strategies for tissue engineering and regenerative medicine is limited by our nascent understanding of how cell populations self-organize into multicellular structures on synthetic scaffolds. Mechanistic insights can be gleaned from the
Asthagiri, Anand R. +1 more
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Prognostic values of Notch receptors in breast cancer
Tumor Biology, 2015 Notch receptors are frequently deregulated in several human malignancies including human breast cancer. Activation of Notch has been reported to cause mammary carcinomas in mice. However, the prognostic value of individual Notch receptors in breast cancer (BC) patients remains elusive. In the current study, we investigated the prognostic value of Notch
Junming, Xu +7 more
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Notch Signaling in Neuroendocrine Tumors
Frontiers in Oncology, 2016 Carcinoids and neuroendocrine tumors (NETs) are a heterogeneous group of tumors that arise from the neuroendocrine cells of the GI tract, endocrine pancreas and the respiratory system.
Judy Sue Crabtree +4 more
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PLoS Computational BiologyThe ubiquitous Notch receptor signalling network is essential for tissue growth and maintenance. Operationally, receptor activity is regulated by two principal, counterposed mechanisms: intercellular Notch transactivation triggered by interactions ...
Daipeng Chen +4 more
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