Results 101 to 110 of about 2,492,882 (302)

Giving It a Twist: One‐Step Fabrication of Aligned Biomimetic Yarn Scaffolds via Rotational Melt Electrofibrillation

Advanced Healthcare Materials, EarlyView.
Due to its multifunctionality, replicating the fibrillar and supramolecular architecture of Collagen I is gaining increasing priority in regenerative medicine. Using rotational Melt Electrofibrillation, we present a powerful method to accurately mimic the ultrastructure of Collagen with polycaprolactone, enabling the one‐step fabrication of three ...
Zan Lamberger, Vivien Priebe, Philipp Stahlhut, Kristina Andelovic, Girish Pattappa, Denitsa Docheva, Sven Heilig, Heike M. Hermanns, Taufiq Ahmad, Jürgen Groll, Gregor Lang, Matthias Ryma   +11 more
wiley   +1 more source

In vivo analysis of the Notch receptor S1 cleavage.

PLoS ONE, 2009
A ligand-independent cleavage (S1) in the extracellular domain of the mammalian Notch receptor results in what is considered to be the canonical heterodimeric form of Notch on the cell surface.
Robert J Lake, Lisa M Grimm, Alexey Veraksa, Andrew Banos, Spyros Artavanis-Tsakonas   +4 more
doaj   +1 more source

A “NOTCH” Deeper into the Epithelial-To-Mesenchymal Transition (EMT) Program in Breast Cancer

Genes, 2019
Notch signaling is a primitive signaling pathway having various roles in the normal origin and development of each multicellular organisms. Therefore, any aberration in the pathway will inevitably lead to deadly outcomes such as cancer.
Rohan Kar, N. Jha, S. Jha, Ankur Sharma, S. Dholpuria, Nidhi Asthana, Kundan Chaurasiya, Vivek Kumar Singh, Shuaib Burgee, P. Nand   +9 more
semanticscholar   +1 more source

Low‐Temperature Fabrication of Thymosin β4‐Loaded Soluble Microneedles to Promote Wound Healing by Specific Binding to Downregulated Immune Regulators Vsig4 and IL22rɑ2

Advanced Healthcare Materials, EarlyView.
Schematic diagram depicting the fabrication and application of thymosin β4 (Tβ4)‐loaded microneedle patches for wound treatment. The Tβ4 was loaded into chitosan (CS) and sucrose MNs under mild conditions (4°C, 65% relative humidity). The Tβ4 MN patch specifically binds to the downregulated immune regulators Vsig4 and IL22rα2, thereby accelerating ...
Shilong He, Mei Yuan, Changkang Feng, Yixuan Zhang, Jinjing Che   +4 more
wiley   +1 more source

In Situ Amine Formation to Modulate MOF‐Derived PdIn N‐Doped Carbon Catalysts

Advanced Materials, EarlyView.
An amine‐assisted approach converts PdIn‐MOF into PdIn intermetallic nanoparticles embedded in N‐doped carbon. In situ‐generated amines trigger early Pd nucleation, producing smaller PdIn domains than direct pyrolysis. Amine sterics and basicity tune composition and particle size, while solvent and amine co‐determine textural features.
Gonzalo Egea, Jordan Santiago Martinez, M. Asunción Molina, Jaime Mazarío, Lucy Costley‐Wood, Christian Cerezo‐Navarrete, Carlo Marini, Eduardo Villalobos‐Portillo, Andrew M. Beale, Pascual Oña‐Burgos   +9 more
wiley   +1 more source

Piezoelectric Stimulation of Neural Cells: Exploring the Synergistic Potential of Hybrid Scaffolds for Enhanced Regeneration

Advanced Materials Interfaces, EarlyView.
Hybrid piezoelectric scaffolds offer a promising route for Central Nervous System regeneration by combining structural and electrical cues to support neural stem cell growth. This review highlights their potential to overcome current challenges in neural tissue engineering by exploring porous hybrid materials, their biological interactions, and ...
Heather F. Titterton, Chris R. Bowen, Hamideh Khanbareh   +2 more
wiley   +1 more source

Structural conservation of Notch receptors and ligands

Seminars in Cell & Developmental Biology, 1998
The Notch signalling pathway is an evolutionarily conserved cell-to-cell communication system utilized multiple times and in many tissues during development. The outcome of an interaction between Notch and its ligands is highly influenced by factors both extrinsic and intrinsic to Notch expressing cells, suggesting that Notch functions either directly ...
openaire   +2 more sources

Notch receptor expression in human brain arteriovenous malformations

Journal of Cellular and Molecular Medicine, 2015
AbstractThe roles of the Notch pathway proteins in normal adult vascular physiology and the pathogenesis of brain arteriovenous malformations are not well‐understood. Notch 1 and 4 have been detected in human and mutant mice vascular malformations respectively.
Hill-Felberg, Sandra, Wu, Hope Hueizhi, Toms, Steven A, Dehdashti, Amir R   +3 more
openaire   +2 more sources

Lattice Structures for Bone Replacement: The Intersection of Bone Biomechanics, Lattice Design, and Additive Manufacturing

Advanced Materials Technologies, EarlyView.
This review outlines how understanding bone's biology, hierarchical architecture, and mechanical anisotropy informs the design of lattice structures that replicate bone morphology and mechanical behavior. Additive manufacturing enables the fabrication of orthopedic implants that incorporate such structures using a range of engineering materials ...
Stylianos Kechagias, Maxwell J. Munford, Frederik C.H. Masure, Richard J. van Arkel, Reece N Oosterbeek   +4 more
wiley   +1 more source

NOTCH1, NOTCH3, NOTCH4, and JAG2 protein levels in human endometrial cancer

Medicina, 2014
Background and objective: Notch signaling is a conserved developmental pathway, which plays an important role in the regulation of cell proliferation, differentiation and death.
Aušra Sasnauskienė, Violeta Jonušienė, Aurelija Krikštaponienė, Stasė Butkytė, Daiva Dabkevičienė, Daiva Kanopienė, Birutė Kazbarienė, Janina Didžiapetrienė   +7 more
doaj   +1 more source