Results 181 to 190 of about 114,328 (209)
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Structural Insights into Notch Receptor-Ligand Interactions
2018Pioneering cell aggregation experiments from the Artavanis-Tsakonas group in the late 1980's localized the core ligand recognition sequence in the Drosophila Notch receptor to epidermal growth factor-like (EGF) domains 11 and 12. Since then, advances in protein expression, structure determination methods and functional assays have enabled us to define ...
Penny A, Handford +4 more
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Intracellular trafficking of Notch receptors and ligands
Experimental Cell Research, 2009The Notch pathway represents a highly conserved signaling network, which regulates the formation and maintenance of various organ systems along development and during adulthood. Direct cell-cell contacts between ligand- and receptor-expressing cells underlie activation of the Notch pathway.
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[Signalling by Notch family receptors].
Comptes rendus des seances de la Societe de biologie et de ses filiales, 1997From nematode to man, the transmembrane receptors of the Notch family act throughout embryonic and post-embryonic development to regulate the acquisition and/or maintenance of specific differentiative states. We will review here our current state of knowledge on Notch receptors structure and signalling activity.
F, Schweisguth +3 more
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Localization of ADAM10 and notch receptors in bone
Bone, 1999In Drosophila melanogaster, the role of the metallodisintegrin, Kuzbanian (kuz), is thought to involve activation of the Drosophila Notch receptor that plays a role in cell-fate determination during neurogenesis and myoblast differentiation. To understand the possible function(s) of a-disintegrin and metalloproteinase (ADAM10), the mammalian ortholog ...
D J, Dallas +5 more
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Evolution of Notch Transmembrane Receptors
2010Notch is the transmembrane receptor of a juxtacrine signalling pathway (Notch pathway) crucial for cell programming during animal development. The active Notch pathway is an innovation of the metazoan lineage: several major components of this molecular network are absent from other eukaryotes. The transmembrane multidomain protein Notch emerged through
Eve, Gazave, Renard, Emmanuelle
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Targeting Notch in oncology: the path forward
Nature Reviews Drug Discovery, 2020Samarpan Majumder +2 more
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Notch signaling pathway: architecture, disease, and therapeutics
Signal Transduction and Targeted Therapy, 2022Kongming Wu, Qian Chu
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Therapeutic modulation of Notch signalling — are we there yet?
Nature Reviews Drug Discovery, 2014Emma R Andersson, Urban Lendahl
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Notch signalling: a simple pathway becomes complex
Nature Reviews Molecular Cell Biology, 2006Sarah Bray
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