Results 11 to 20 of about 3,424 (135)

The role of cytokines in ovarian cancer drug resistance. [PDF]

Int J Cancer
Abstract Ovarian cancer is the leading cause of death among women diagnosed with female reproductive system cancers. While significant advances have been made in treating various types of cancer, progress in ovarian cancer treatment over the past 20 years has been minimal, and the treatment course of ovarian cancer is not linear. Although many patients
Wang L, Zang Y, Dejenie R, Bing J, Dong S, Zhang Y, Zhu Y, Li J.   +7 more
europepmc   +2 more sources

A Mendelian Randomization Study and Experimental Validation Investigating the Potential Relationship Among Interleukin-6 Receptor Subunit Beta, Obesity, and Alzheimer's Disease. [PDF]

Brain Behav
This study employs Mendelian randomization (MR) aimed at systematically evaluating the relationship among interleukin‐6 receptor subunit beta, obesity, and Alzheimer's disease (AD). ABSTRACT Objective This study employs Mendelian randomization (MR) aimed at systematically evaluating the relationship among interleukin‐6 receptor subunit beta, obesity ...
Liu Y, Song N, Wang Q, Cui P, Min D.
europepmc   +2 more sources

Definition of a family of tissue-protective cytokines using functional cluster analysis: a proof-of-concept study [PDF]

, 2014
The discovery of the tissue-protective activities of erythropoietin (EPO) has underlined the importance of some cytokines in tissue-protection, repair, and remodeling.
Annenkov, Alexander, Ermilov, Peter, Ghezzi, Pietro, Mengozzi, Manuela, Pearl, Frances   +4 more
core   +3 more sources

Reduction of circulating cholesterol and apolipoprotein levels during sepsis [PDF]

, 1999
Sepsis with multiple organ failure is frequently associated with a substantial decrease of cholesterol levels. This decrease of cholesterol is strongly associated with mortality suggesting a direct relation between inflammatory conditions and altered ...
Alvarez C, Chajek-Shaul T, Engelmann H, Ettinger WH, Ettinger WH, Ettinger WH, Feingold KR, Feingold KR, Flegel WA, Gouni I, Graham A, Greenberg AS, Grove RI, Grunfeld C, Hubsch AP, Ishibashi S, Kipp HA, Moran CS, Netea MG, Pacelli F, Pak YK, Read TE, Semb H, Stopeck AT, Van Gameren MM, Weinstock C, Wilson DE, Yokoyama K   +27 more
core   +1 more source

New insights in cellular senescence: The pituitary model. [PDF]

J Neuroendocrinol
Senescence is a pivotal process in pituitary tumorigenesis. Recent advances have elucidated the complex mechanisms by which key factors, including IL‐6, establish and maintain senescence in these tumors. Given the critical role of senescence and the development of novel techniques to detect senescent cells, the identification of biomarkers and the ...
Herbstein F, Rosmino J, Guitelman MA, Cagliero J, Gonilski-Pacin D, Ciancio Del Giudice N, Fiz M, Fuertes M, Arzt E.   +8 more
europepmc   +2 more sources

TYK2-induced phosphorylation of Y640 suppresses STAT3 transcriptional activity [PDF]

, 2017
STAT3 is a pleiotropic transcription factor involved in homeostatic and host defense processes in the human body. It is activated by numerous cytokines and growth factors and generates a series of cellular effects.
De Bosscher, Karolien, De Cauwer, Lode, Icardi, Laura, Mori, Raffaele, Peelman, Frank, Tavernier, Jan, Van Der Heyden, José, Wauman, Joris   +7 more
core   +3 more sources

Serum Levels of IL-6 Type Cytokines and Soluble IL-6 Receptors in Active B-Cell Chronic Lymphocytic Leukemia and in Cladribine Induced Remission

Mediators of Inflammation, 1999
We have investigated the serum concentrations of interleukin-6 (IL-6) and two IL-6 family cytokines-oncostatin M (OSM) and leukemia inhibitory factor (LIF)-in 63 patients with B-cell chronic lymphocytic leukemia (B-CLL) and 17 healthy controls using the ...
T. Robak, A. Wierzbowska, M. Blasinska-Morawiec, A. Korycka, J. Z. Blonski   +4 more
doaj   +1 more source

Leukemia inhibitory factor inhibits erythropoietin-induced myelin gene expression in oligodendrocytes [PDF]

, 2018
Background: The pro-myelinating effects of leukemia inhibitory factor (LIF) and other cytokines of the gp130 family, including oncostatin M (OSM) and ciliary neurotrophic factor (CNTF), have long been known, but controversial results have also been ...
Ghezzi, Pietro, Gyetvai, Georgina, Heikal, Lamia, Mengozzi, Manuela, Roe, Cieron   +4 more
core   +5 more sources

Precise mapping of the CD95 pre-ligand assembly domain. [PDF]

, 2012
International audiencePre-association of CD95 at the plasma membrane is mandatory for efficient death receptor signaling. This homotrimerization occurs through self-association of an extracellular domain called the pre-ligand assembly domain (PLAD ...
Daburon, Sophie, Edmond, Valérie, Ghali, Benoist, Legembre, Patrick, Moreau, Jean-François, Penna, Aubin, Taupin, Jean-Luc   +6 more
core   +4 more sources

Late gestation modulation of fetal glucocorticoid effects requires the receptor for leukemia inhibitory factor: an observational study [PDF]

, 2003
Background Ablation of the low-affinity receptor subunit for leukemia inhibitory factor (LIFR) causes multi-systemic defects in the late gestation fetus.
Nelson Angelique M, Ware Carol B, Liggitt Denny   +2 more
core   +2 more sources