Cytokine-centered strategies to boost cancer immunotherapy. [PDF]
Mol OncolIn this Viewpoint article, we discuss the three main cytokine‐centered approaches that may have an impact in the context of cancer immunotherapy: (1) modulation of cytokines to increase the efficacy of immune checkpoint inhibitors (ICIs), (2) cytokine inhibition to decrease immunotherapy‐associated side effects, and (3) potential of cytokines as ...
Manzano S, Caffarel MM.
europepmc +2 more sources
A Novel Missense Mutation in Oncostatin M Receptor Beta Causing Primary Localized Cutaneous Amyloidosis [PDF]
, 2014 Primary localized cutaneous amyloidosis (PLCA) is a chronic skin disorder, caused by amyloid material deposition in the upper dermis. Autosomal dominant PLCA has been mapped earlier to pathogenic missense mutations in the OSMR gene, which encodes the ...
Amoli, Mahsa M. +5 more
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Oncostatin M Promotes Mammary Tumor Metastasis to Bone and Osteolytic Bone Degradation [PDF]
, 2012 Oncostatin M (OSM) is an interleukin-6 (IL-6) family cytokine that has been implicated in a number of biological processes including inflammation, hematopoiesis, immune responses, development, and bone homeostasis.
Anderson, Robin +7 more
core +2 more sources
Interactions between fibroblast growth factors and Notch regulate neuronal differentiation [PDF]
, 2001 The differentiation of precursor cells into neurons has been shown to be influenced by both the Notch signaling pathway and growth factor stimulation.
Bartlett, PF +4 more
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Oncostatin m is produced in adipose tissue and is regulated in conditions of obesity and type 2 diabetes [PDF]
, 2013 CONTEXT: Adipose tissue is a highly active endocrine organ that secretes many factors that affect other tissues and whole-body metabolism. Adipocytes are responsive to several glycoprotein 130 (gp130) cytokines, some of which have been targeted as ...
Albasanz-Puig +63 more
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New developments in the genetics, pathogenesis, and therapy of IgA nephropathy [PDF]
, 2015 Recent years have brought notable progress in the field of IgA nephropathy. Here, we highlight important new directions and latest developments, including successful discovery of several genetic susceptibility loci, formulation of the multihit ...
Appel, Gerald B. +3 more
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Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells [PDF]
, 2009 Oncostatin M (OSM) is released together with type I interferon (IFN) by activated dendritic cells, suggesting a concerted action of these cytokines in the biological response against infection.
Larrea, E. (Esther) +6 more
core +1 more source
Advanced Science, EarlyView.This study highlights that radioimmunotherapy drives crosstalk between fibroblasts and immune cells (especially macrophages) in the cardiac microenvironment, with IL‐6 as the key mediator, and tocilizumab alleviates cardiac fibrosis by targeting this interplay.
Yuxi Luo +10 more
wiley +1 more source
Breast Cancer Cells Stimulate Neutrophils to Produce Oncostatin M: Potential Implications for Tumor Progression [PDF]
, 2005 Tumor-associated and tumor-infiltrating neutrophils (TAN) and macrophages (TAM) can account for as much as 50% of the total tumor mass in invasive breast carcinomas.
Holzer, Ryan G. +4 more
core +1 more source
Identifying Cytokine Motif‐Containing, Immunomodulatory Bacterial Proteins in Human Gut Microbiome
Advanced Science, EarlyView.By building and constructing HMM (Upper left, blue), the authors identify CMCPs in bacteria genomes and CRC related metagenomes and enriched CRC‐related CMCPs (Upper right, blue). They analyze sequence and structural similarity of hits (Lower left, green), test function with engineered EcN delivered to tumors in a mouse tumor model (Lower right, pink ...
Ziyu Wang +12 more
wiley +1 more source