Involution of the mouse mammary gland is associated with an immune cascade and an acute-phase response, involving LBP, CD14 and STAT3 [PDF]
, 2004 INTRODUCTION: Involution of the mammary gland is a complex process of controlled apoptosis and tissue remodelling. The aim of the project was to identify genes that are specifically involved in this process.
Bell, A.K. +9 more
core
Hemidesmosome Mutations Contribute to the Onset and Severity of Acquired Autoimmune Bullous Diseases
MedComm, Volume 7, Issue 3, March 2026.This study examined hemidesmosome assembly‐related genes in pemphigoid diseases, revealing variants linked to disease onset and severity. Functional analyses, including Caenorhabditis elegans models, Ker‐CT transcriptomics, human proteomics, etc., demonstrated that ITGA6 mutations destabilize hemidesmosomes, disrupt dermal–epidermal adhesion, and ...
Shan Cao +19 more
wiley +1 more source
Cardiac oxidative stress and inflammatory cytokines response after myocardial infarction [PDF]
, 2015 Oxidative stress in heart failure or during ischemia/reperfusion occurs as a result of the excessive generation or accumulation of free radicals or their oxidation products.
Cerretani D. +6 more
core +1 more source
Molecular Microbiology, Volume 125, Issue 3, Page 185-202, March 2026.Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç +4 more
wiley +1 more source
Ifitm3 Limits the Severity of Acute Influenza in Mice [PDF]
, 2012 Interferon-induced transmembrane (IFITM) proteins are a family of viral restriction factors that inhibit the entry processes of several pathogenic viruses, including influenza A virus (IAV), in vitro.
Bailey, Charles C +3 more
core +7 more sources
Modulation of human JAK-STAT pathway signaling by functionally conserved regulators [PDF]
, 2012 Both the core JAK-STAT pathway components and their in vivo roles have been widely conserved between vertebrates and invertebrate models such as Drosophila melanogaster.
Müller, P. +2 more
core +1 more source
Novel Genetic Findings in Stuve‐Wiedemann Syndrome: A Case Report and Review of Literature
Clinical Case Reports, Volume 14, Issue 1, January 2026.ABSTRACT Stuve‐Wiedemann Syndrome (SWS) is a rare autosomal recessive condition, first reported in 1971 by Stuve and Wiedemann. It is associated with pathogenic or likely pathogenic homozygous or compound heterozygous variants in the Leukemia Inhibitory Factor Receptor (LIFR) gene.
Khalid Hamasalih Hamasharef +4 more
wiley +1 more source
Modulation of human JAK-STAT pathway signaling by functionally conserved regulators [PDF]
, 2014 Both the core JAK-STAT pathway components and their in vivo roles have been widely conserved between vertebrates and invertebrate models such as Drosophila melanogaster.
Müller, Patrick +2 more
core +1 more source
STAT3 SH2 Domain Aspartic Acid 661 Mutations Activate Immune Gene Programs
Journal of Cellular and Molecular Medicine, Volume 30, Issue 1, January 2026.ABSTRACT The conserved aspartic acid residue D661 within the STAT3 SH2 domain is a recurrent mutational hotspot in hematologic malignancies, including T‐cell large granular lymphocytic leukaemia, myelodysplastic syndromes and acute lymphoblastic leukaemia. To define the functional consequences of distinct STAT3D661 variants, we integrated computational,
Hye Kyung Lee +10 more
wiley +1 more source
Inhibition of interleukin-6 trans-signaling in the brain facilitates recovery from lipopolysaccharide-induced sickness behavior [PDF]
, 2011 Background Interleukin (IL)-6 is produced in the brain during peripheral infection and plays an important but poorly understood role in sickness behavior.
Michael D Burton +2 more
core +1 more source