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Parathyroid hormone and parathyroid hormone-related peptide, and their receptors
Biochemical and Biophysical Research Communications, 2005Parathyroid hormone (PTH) has a central role in the regulation of serum calcium and phosphate, while parathyroid hormone-related peptide (PTHrP) has important developmental roles. Both peptides signal through the same receptor, the PTH/PTHrP receptor (a class B G-protein-coupled receptor).
Robert C, Gensure +2 more
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Parathyroid hormone-receptor interactions
Trends in Endocrinology & Metabolism, 1990Identification of sites within the antagonist peptide of parathyroid hormone (PTH) that are "tolerant" of a wide range of amino acid substitutions has led to the design of new PTH antagonists. These antagonists have increased potency because of substitution, at appropriate sites, of amino acids that increase the interaction of the ligand with its ...
M P, Caulfield, M, Rosenblatt
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AUTOANTIBODIES TO PARATHYROID HORMONE RECEPTOR
The Lancet, 1978Autoantibodies which block the binding of parathyroid hormone to membrane receptors for the hormone were detected in the sera (especially in the IgG fraction) of 49 out of 50 uraemic patients with secondary hyperparathyroidism (patients with high levels of C-regional parathyroid hormone). These antibodies are species-specific.
H, Jüppner +2 more
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Endosomal parathyroid hormone receptor signaling
American Journal of Physiology-Cell Physiology, 2022The canonical model for G protein-coupled receptors (GPCRs) activation assumes that stimulation of heterotrimeric G protein signaling upon ligand binding occurs solely at the cell surface and that duration of the stimulation is transient to prevent overstimulation.
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The Parathyroid Hormone 2 (PTH2) Receptor
Receptors and Channels, 2002The human PTH2 receptor binds and is activated at high potency by PTH and by the recently discovered peptide tuberoinfundibular peptide of 39 residues (TIP39). Rat and zebrafish PTH2 receptors are more weakly activated by PTH, suggesting that TIP39 may be the natural ligand for the PTH2 receptor.
T B, Usdin, T I, Bonner, S R J, Hoare
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Frontiers in Neuroendocrinology, 2000
The parathyroid hormone (PTH) family currently includes three peptides and three receptors. PTH regulates calcium homeostasis through bone and kidney PTH1 receptors. PTH-related peptide, probably also through PTH1 receptors, regulates skeletal, pancreatic, epidermal, and mammary gland differentiation and bladder and vascular smooth muscle relaxation ...
T B, Usdin +4 more
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The parathyroid hormone (PTH) family currently includes three peptides and three receptors. PTH regulates calcium homeostasis through bone and kidney PTH1 receptors. PTH-related peptide, probably also through PTH1 receptors, regulates skeletal, pancreatic, epidermal, and mammary gland differentiation and bladder and vascular smooth muscle relaxation ...
T B, Usdin +4 more
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Current Opinion in Nephrology and Hypertension, 1997
Parathyroid hormone-related peptide has recently been shown to have important functions in the control of cellular growth and differentiation. Studies using knockout and transgenic technology have played a key part in the development of our understanding of its physiological role in endochondral bone development and adult skeletal homeostasis.
A C, Karaplis, L, Vautour
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Parathyroid hormone-related peptide has recently been shown to have important functions in the control of cellular growth and differentiation. Studies using knockout and transgenic technology have played a key part in the development of our understanding of its physiological role in endochondral bone development and adult skeletal homeostasis.
A C, Karaplis, L, Vautour
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Parathyroid Hormone-Related Peptide (PTHrP) and Parathyroid Hormone (PTH)/PTHrP Receptor
Critical Reviews in Eukaryotic Gene Expression, 1998Parathyroid hormone-related peptide (PTHrP) has been identified as the factor responsible for the humoral hypercalcemia of malignancy (HHM). Since the cloning of the cDNA, it has become clear that PTHrP is a prohormone that is posttranslationally cleaved to yield a complex family of peptides.
B, Lanske, H M, Kronenberg
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Localization of parathyroid hormone/parathyroid hormone-related peptide receptor mRNA in kidney
American Journal of Physiology-Renal Physiology, 1996In kidney, parathyroid hormone (PTH) exerts differential distal effects along the nephron. To define cells expressing receptors for PTH in kidney, we localized PTH/ PTH-related peptide (PTH/PTHrP) receptor mRNA in rat kidney by in situ hybridization. PTH/PTHrP receptor mRNA is localized to glomerular podocytes, convoluted and straight proximal tubules,
K, Lee +6 more
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Biochemistry, 1998
Native PTH/PTHrP receptors in ROS 17/2.8 cells are downregulated after PTH treatment. Since downregulation may involve receptor phosphorylation, we examined PTH/PTHrP receptor phosphorylation in ROS 17/2.8 cells and we mapped the agonist-induced phosphorylation sites using recombinant PTH/PTHrP receptors expressed in LLCPK-1 and COS-7 cells.
F, Qian, A, Leung, A, Abou-Samra
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Native PTH/PTHrP receptors in ROS 17/2.8 cells are downregulated after PTH treatment. Since downregulation may involve receptor phosphorylation, we examined PTH/PTHrP receptor phosphorylation in ROS 17/2.8 cells and we mapped the agonist-induced phosphorylation sites using recombinant PTH/PTHrP receptors expressed in LLCPK-1 and COS-7 cells.
F, Qian, A, Leung, A, Abou-Samra
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