Results 241 to 250 of about 39,335 (289)

Parathyroid Hormone Resistance and Autoantibodies to the PTH1 Receptor

New England Journal of Medicine, 2021
We describe two cases of acquired parathyroid hormone (PTH) resistance consequent to the development of serum PTH type 1 receptor (PTH1R) autoantibodies, which block PTH binding and signaling. Both cases were associated with other autoimmune manifestations, and one case was associated with atypical membranous glomerulonephritis.
Adel, Mandl, Peter D, Burbelo, Giovanni, Di Pasquale, You Sher, Tay, James, Welch, Michail S, Lionakis, Sergio D, Rosenzweig, Meryl A, Waldman, Blake M, Warner, Brian, Walitt, Michael T, Collins, James E, Balow, John A, Chiorini, William F, Simonds, Sunita K, Agarwal, Jenny E, Blau, Lee S, Weinstein   +16 more
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Parathyroid hormone-parathyroid hormone-related peptide receptor expression and function in otosclerosis

American Journal of Physiology-Endocrinology and Metabolism, 1999
The aim of this study was to investigate the possibility that an abnormality related to parathyroid hormone (PTH) action is involved in the increased bone turnover observed in otosclerosis. To do so, expression and function of the PTH-PTH-related peptide (PTHrP) receptor were studied in the involved tissue (stapes) and compared with that in control ...
A B, Grayeli, O, Sterkers, P, Roulleau, P, Elbaz, E, Ferrary, C, Silve   +5 more
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A G Protein-Linked Receptor for Parathyroid Hormone and Parathyroid Hormone-Related Peptide

Science, 1991
The complementary DNA encoding a 585-amino acid parathyroid hormone-parathyroid hormone-related peptide (PTH-PTHrP) receptor with seven potential membrane-spanning domains was cloned by COS-7 expression using an opossum kidney cell complementary DNA (cDNA) library.
Harald Jüppner, Abdul-Badi Abou-Samra, Mason Freeman, Xiang F. Kong, Ernestina Schipani, Jennifer Richards, Lee F. Kolakowski, Janet Hock, John T. Potts, Henry M. Kronenberg, Gino V. Segre   +10 more
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Parathyroid hormone: new assays, new receptors

Seminars in Nephrology, 2004
Accurate measurements of parathyroid hormone (PTH) in plasma are necessary for the assessment, monitoring, and therapy of disorders of bone and mineral metabolism including renal osteodystrophy. Assays for PTH have evolved to provide 2-site immunometric assays that are highly specific for the intact 84 amino-acid peptide, PTH (1-84). With the advent of
Kevin J, Martin, Irme, Akhtar, Esther A, González   +2 more
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Identification of a Receptor-Binding Region in Parathyroid Hormone*

Endocrinology, 1980
Analyses of structure/activity relations for parathyroid hormone (PTH) have revealed that the sequence PTH- (1–34) is fully active in all known bioassay systems and that deletion of the first two amino-terminal residues results in the loss of all or virtually all biological activity but not in the loss of the property of binding to renal receptors in ...
M, Rosenblatt, G V, Segre, G A, Tyler, G L, Shepard, S R, Nussbaum, J T, Potts   +5 more
openaire   +2 more sources

Receptors for parathyroid hormone and parathyroid hormone-related peptide: exploration of their biological importance

Bone, 1999
The molecular cloning of the PTH/PTHrP receptor (also termed PTH1 receptor; PTH1R) and the receptors for calcitonin and secretin established a distinct family of G protein-coupled receptors. These receptors are characterized by seven membranespanning domains, a long amino-terminal extracellular domain, and a long carboxyl-terminal intracellular tail ...
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Expression of Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor in Vascular Endothelial Cells

Journal of Cardiovascular Pharmacology, 1998
The parathyroid hormone (PTH)/PTH-related protein (PTHrP) receptor has been reported to be expressed in many tissues, including vascular smooth-muscle cells (VSMCs), but it has not been identified in vascular endothelial cells. To determine whether vascular endothelial cells can express the PTH/PTHrP receptor, its gene expression was examined in simian
B, Jiang, S, Morimoto, J, Yang, T, Niinoabu, K, Fukuo, T, Ogihara   +5 more
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Identification and Characterization of Parathyroid Hormone/Parathyroid Hormone-related Peptide Receptor in Cultured Astrocytes

Biochemical and Biophysical Research Communications, 1994
Parathyroid hormone (PTH)/parathyroid hormone-related peptide (PTHrP) receptor expressed in rat cultured cortical type I astrocytes was identified and characterized. Northern blot analysis demonstrated that the PTH/PTHrP receptor mRNA is expressed in astrocytes. A human PTH fragment, PTH [1-34], stimulated adenylate cyclase with the EC50 value of 3 nM,
H, Hashimoto, H, Aino, N, Ogawa, S, Nagata, A, Baba   +4 more
openaire   +2 more sources

Receptors | Parathyroid Hormone/Parathyroid Hormone-Related Protein Receptor

2021
Thomas J. Gardella, Justin J. Miller
openaire   +1 more source

Calcium Receptor and Regulation of Parathyroid Hormone Secretion

Reviews in Endocrine and Metabolic Disorders, 2000
The cloning of the CaR has made it possible to show definitively that the CaR is a critical mediator of the inhibitory effect of high Cao2+ on PTH secretion and parathyroid cellular proliferation. The receptor may also mediate the suppressive action of high Cao2+ on PTH gene expression, while its involvement in several other known actions of Cao2+ on ...
openaire   +2 more sources