Results 111 to 120 of about 646,259 (330)
Editorial: Pattern-recognition receptors: Genetics, immunity, pathology
Frontiers in Cellular and Infection Microbiology, 2022 Petro Starokadomskyy
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Plant Physiology, 2016 Receptor-like cytoplasmic kinases PCRK1 and PCRK2 transduce defense signals from pattern recognition receptors to activate pathogen-induced SA biosynthesis. Salicylic acid (SA) serves as a critical signaling molecule in plant defense.
Qing Kong +9 more
semanticscholar +1 more source
Pattern recognition receptors: a contemporary view on liver diseases [PDF]
, 2010 Pattern recognition receptors (PRRs) function as sensors of microbial danger signals enabling the vertebrate host to initiate an immune response. PRRs are present not only in immune cells but also in liver parenchymal cells and the complexity of the cell
Szabo, Gyongyi +2 more
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Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Plant pattern-recognition receptors controlling innate immunity
Science China Life Sciences, 2016 Plants are exposed to numerous potential pathogenic microbes. To counter the threat, plants have evolved diverse pattern- recognition receptors (PRRs), which are receptor kinases (RKs) and receptor proteins (RPs) specialized to detect conserved pathogen ...
Lei Li +3 more
semanticscholar +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source
FEBS Letters, EarlyView.Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura +2 more
wiley +1 more source
COMMENSAL MICROFLORA AND ENDOGENOUS INDUCTORS OF PATHOPHYSIOLOGICAL REACTIONS OF INNATE IMMUNITY
Журнал микробиологии, эпидемиологии и иммунобиологии, 2015 This paper content analytical review of literature on commensal microflora and endogenous inductors of pathophysiological reactions of innate immunity.
W. M Bondarenko +2 more
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The role of BRI1-associated kinase 1 (BAK1) in the regulation of plant innate immunity : functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana [PDF]
, 2014 The role of BRI1-ASSOCIATED KINASE 1 (BAK1) in the regulation of plant innate immunity: functional and genetic characterization of BAK1 overexpression in Arabidopsis thaliana SUMMARY BAK1 (BRI1-ASSOCIATED KINASE 1) is an intensively studied member ...
Kiss-Papp, Márta
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FEBS Letters, EarlyView.Plasma membranes contain dynamic nanoscale domains that organize lipids and receptors. Because viruses operate at similar scales, this architecture shapes early infection steps, including attachment, receptor engagement, and entry. Using influenza A virus and HIV‐1 as examples, we highlight how receptor nanoclusters, multivalent glycan interactions ...
Jan Schlegel, Christian Sieben
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