Results 261 to 270 of about 646,259 (330)

Iron homeostasis disruption and lipid peroxidation in skeletal muscle during short‐term immobilization

FEBS Open Bio, EarlyView.
14‐day casting‐induced immobilization reduced gastrocnemius muscle mass and increased non‐heme iron and ferritin heavy chain levels. Despite iron accumulation, transferrin receptor 1 and iron regulatory protein 2 were paradoxically upregulated. Lipid peroxidation was elevated without compensatory antioxidant responses.
Haruka Yokogawa, Kazuhiko Higashida, Naoya Nakai   +2 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Gut-derived bacterial extracellular vesicles: the microbial dark matter contributing to host inflammation and cardiometabolic disease. [PDF]

Gut Microbes
Oliver B, Sun M, Lee YS, Cho S, Zhu T, Durgan D, Sweeney G.   +6 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Decoding Host-Pathogen Dynamics in <i>Klebsiella pneumoniae</i> Infections: Mechanisms of Cell Death Regulation and Host-Directed Therapies for Sepsis. [PDF]

Antibiotics (Basel)
Thomas SS, Kannan K, Abhinand K, Menon AM, Ranjith G, Sony SM, Babu P, Kumar GB, Nair BG, Arun KB, Edison LK, Madhavan A.   +11 more
europepmc   +1 more source

Different Immune Cells Modified With Chimeric Antigen Receptors Are Being Applied to Ovarian Cancer: Which Is the Most Effective? [PDF]

Cancer Med
Wang L, Cao Y, Ren Y, Zhang Y, Wang L.
europepmc   +1 more source

<i>Galleria mellonella</i> proteomic response to infection with <i>Streptococcus pyogenes</i>. [PDF]

Virulence
Abt-Becker C, Burzlaff J, Mikkat S, Kreikemeyer B, Patenge N.   +4 more
europepmc   +1 more source

Danger or Salvation? The Role of DAMPs in Cancer Therapy. [PDF]

Cancers (Basel)
Vedunova AA, Guryev EL, Gudkov SV, Mishchenko TA, Vedunova MV.   +4 more
europepmc   +1 more source

Subverting Host Defense from Within: Innate Immune Modulation by <i>Coxiella burnetii</i>. [PDF]

Pathogens
Busbee AO, Arunima A, Samuel JE, van Schaik EJ.   +3 more
europepmc   +1 more source

Polysaccharide-based anticancer therapeutics: molecular mechanisms, translational advances, and the road toward precision oncology. [PDF]

Front Pharmacol
Wei M, Gao C, Li S, Wang Y, Cao J, Hao S, Li H, Zhang H, Liu S.   +8 more
europepmc   +1 more source