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Pattern recognition receptors as potential drug targets in inflammatory disorders.
Advances in Protein Chemistry and Structural Biology, 2020Pattern recognition receptors (PRRs) are a key part of the innate immune system, the body's first line of defense against infection and tissue damage. This superfamily of receptors including Toll-like receptors (TLRs), NOD-like receptors (NLRs), C-type ...
D. McKernan
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Control of adaptive immunity by pattern recognition receptors
ImmunityOne of the most significant conceptual advances in immunology in recent history is the recognition that signals from the innate immune system are required for induction of adaptive immune responses.
Shaina L. Carroll +2 more
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Pattern recognition receptors in Drosophila immune responses.
Developmental and Comparative Immunology, 2019Insects, which lack the adaptive immune system, have developed sophisticated innate immune system consisting of humoral and cellular immune responses to defend against invading microorganisms.
Yuzhen Lu +7 more
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Plant Pattern Recognition Receptors
Methods in Molecular Biology, 2017Libo Shan, P. He
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Current Opinion in Insect Science, 2019
Through evolution, selection pressures cause both insects and the pathogens attacking them to adapt so that they will both survive and this has been called the co-evolutionary 'arms race'. Insects expand their repertoire of pattern recognition receptors (
Xialu Wang +3 more
semanticscholar +1 more source
Through evolution, selection pressures cause both insects and the pathogens attacking them to adapt so that they will both survive and this has been called the co-evolutionary 'arms race'. Insects expand their repertoire of pattern recognition receptors (
Xialu Wang +3 more
semanticscholar +1 more source
Visualising pattern recognition receptor signalling
Biochemical Society Transactions, 2017Signalling by pattern recognition receptors (PRRs) is critical for protecting the host against pathogens. Disruption of these signalling pathways has been implicated in many diseases ranging from infection susceptibility to cancer and autoimmune disease.
Charlotte, Macleod, Clare E, Bryant
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Identification and functions of pattern-recognition receptors
Journal of Allergy and Clinical Immunology, 2010Since the identification of Toll-like receptors, our knowledge about pattern-recognition receptors (PRRs) has increased rapidly. Classes of PRRs that have been recently discovered include RIG-I-like receptors, Nod-like receptors, and C-type lectin receptors.
Yutaro, Kumagai, Shizuo, Akira
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Expression of pattern recognition receptors in cholesteatoma
European Archives of Oto-Rhino-Laryngology, 2013Although many immunologic mechanisms have been investigated in studies of the pathogenesis of cholesteatoma, the role of pattern recognition receptors (PRRs) has not been fully determined. Therefore, we assessed innate immune responses in patients with cholesteatoma. We prospectively evaluated 21 patients with acquired cholesteatoma between August 2010
Ho Yun, Lee +4 more
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Pattern recognition receptor function in neutrophils
Trends in Immunology, 2013Previously, neutrophils were largely ignored in the pattern recognition receptor (PRR) signaling field. However, interest in neutrophil biology has been revitalized by emerging roles for neutrophils in promoting protective and pathogenic T helper (Th)17-driven immune responses and in orchestrating innate and adaptive immunity via cytokine/chemokine ...
Thomas, Christina J., Schroder, Kate
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Pattern Recognition by Toll-like Receptors
2009The mammalian immune system senses pathogens through pattern recognition receptors and responds with activation. The Toll-like receptors (TLRs) that are expressed on antigen presenting cells such as macrophages and dendritic cells play a critical role in this process.
Stefan, Bauer +2 more
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