Results 231 to 240 of about 507,789 (292)
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Opioid Peptides and their Receptors
1982The three agonists, methionine-enkephalin, leucine-enkephalin and beta-endorphin have different pharmacological patterns. It may be of particular importance that they vary in their relative affinities to the enkephalin and naltrexone binding sites in the brain; the former are probably related to delta-receptors prevalent in the mouse vas deferens and ...
H.W. Kosterlitz +2 more
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Peptide Receptors on Astrocytes
Frontiers in Neuroendocrinology, 1998In recent years, it has become apparent that astrocytes (at least in vitro) harbor functional receptors to almost all possible neurotransmitters (with the potential noticeable exception of acetylcholine nicotinic receptors). Peptides are no exception, since receptors to all neuropeptides known to be produced in the CNS have been found on cultured ...
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1991
A large number of peptide hormones have been identified and are known to elicit a wide variety of biological responses from target cells throughout the body. These hormones exert their effects by interaction with receptors which are integral components of the cell surface membrane.
J, Lloyd, R, Tibolt, G V, Childs
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A large number of peptide hormones have been identified and are known to elicit a wide variety of biological responses from target cells throughout the body. These hormones exert their effects by interaction with receptors which are integral components of the cell surface membrane.
J, Lloyd, R, Tibolt, G V, Childs
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Receptors for Relaxin Family Peptides
Annals of the New York Academy of Sciences, 2005Abstract: Recent studies have identified four receptors that are the physiological targets for relaxin family peptides. All are class I (rhodopsin like) G‐protein‐coupled receptors with LGR7 (RXFP1) and LGR8 (RXFP2) being type C leucine‐rich repeat‐containing receptors, whereas GPCR135 (RXFP3) and GPCR142 (RXFP4) resemble receptors that respond to ...
Bathgate, R. +4 more
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Peptide Receptors in the Airways
American Review of Respiratory Disease, 1987Abstract Two categories of peptides exert opposing effects on the isolated guinea pig trachea. Neurokinins (substance P [SP] and congeners) provoke contraction, and kinins (bradykinin) provoke relaxation. Both peptide categories promote the release of relaxing prostaglandins that oppose the contractions induced by neurokinins and ...
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MHC molecules as peptide receptors
Current Opinion in Immunology, 1993The central unit for regulation of the specific immune system is a trimolecular complex made up of the T cell antigen receptor, the MHC molecule, and the MHC ligand. The third component is a peptide derived as a degradation product from a protein. During recent years there has been some progress in understanding the interaction between MHC molecules ...
H G, Rammensee, K, Falk, O, Rötzschke
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Peptide‐Based Carbohydrate Receptors
Chemistry – A European Journal, 2014AbstractA broad spectrum of physiological processes is mediated by highly specific noncovalent interactions of carbohydrates and proteins. In a recent communication we identified several cyclic hexapeptides in a dynamic combinatorial library that interact selectively with carbohydrates with high binding constants in water.
Melanie, Rauschenberg +3 more
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Non-peptide ligands for peptide receptors
Trends in Pharmacological Sciences, 1989Considerable progress has been made in synthesizing peptide analogs with improved stability for probing function of peptide-receptor systems. However, since peptide ligands are usually unsuitable for development as potent orally active long-duration therapeutic agents, considerable research effort is being directed to the development of non-peptidal ...
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Peptide YY receptors in the brain
Biochemical and Biophysical Research Communications, 1988Radiolabelled ligand binding studies demonstrated that specific receptors for peptide YY are present in the porcine as well as the canine brains. Peptide YY was bound to brain tissue membranes via high-affinity (dissociation constant, 1.39 X 10(-10)M) and low-affinity (dissociation constant, 3.72 X 10(-8)M) components.
A, Inui +9 more
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Receptor antagonists for gastrointestinal peptides
American Journal of Physiology-Gastrointestinal and Liver Physiology, 1993Receptors for gastrointestinal peptides are all G protein-coupled receptors. Since the discovery that dibutyryl guanosine 3',5'-cyclic monophosphate was a cholecystokinin-receptor antagonist, a variety of receptor antagonists have been developed for a number of different gastrointestinal peptides.
M E, Presti, J D, Gardner
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