Results 241 to 250 of about 507,789 (292)
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Relaxin Family Peptides and Their Receptors
Physiological Reviews, 2013There are seven relaxin family peptides that are all structurally related to insulin. Relaxin has many roles in female and male reproduction, as a neuropeptide in the central nervous system, as a vasodilator and cardiac stimulant in the cardiovascular system, and as an antifibrotic agent.
Bathgate, RAD +5 more
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Biology of natriuretic peptides and their receptors
Peptides, 2005Increasing evidence suggests that natriuretic peptides (NPs) play diverse roles in mammals, including renal hemodynamics, neuroendocrine, and cardiovascular functions. Collectively, NPs are classified as hypotensive hormones; the main actions of NPs are implicated in eliciting natriuretic, diuretic, steroidogenic, antiproliferative, and vasorelaxant ...
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pH profile of a peptide receptor
Comparative Biochemistry and Physiology, 1969Abstract 1. 1. The activation of the feeding response in Hydra littoralis was used as a model system to investigate the mechanism by which a specific peptide activates its complementary cellular receptor to give a co-ordinated biological response. 2. 2. Through use of a modified Lineweaver-Burk equation and a modified Dixon equation, it was
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Peptide hormone and receptor evolution
General and Comparative Endocrinology, 2007An important and fascinating theme that unifies both invertebrate and vertebrate endocrinologists is that of the evolution of peptide precursor and receptor genes. Peptide signalling plays a crucial role in processes that control decisive physiological events in organisms as divergent as yeast and mammals.
Dan, Larhammar, Jozef, Vanden Broeck
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Formyl-peptide receptors revisited
Trends in Immunology, 2002Leukocytes accumulate at sites of inflammation and microbial infection in direct response to locally produced chemotactic factors, which signal through specific G protein-coupled receptors. The first chemotactic factors to be structurally defined were the N-formyl peptides. Unlike other leukocyte chemoattractants, N-formyl peptides could originate from
Yingying, Le +2 more
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Peptide Antagonist of the Androgen Receptor
Current Pharmaceutical Design, 2010Androgen receptor (AR) is a steroid hormone receptor that is activated by endogenous androgens, mainly testosterone and 5alpha-dihydrotestosterone (5alpha-DHT). AR is also an important drug target, and AR antagonists (antiandrogens) have been widely used for prostate cancer therapy.
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Urotensin‐II receptor peptide agonists
Medicinal Research Reviews, 2004AbstractUrotensin II (U‐II) has been known for over 30 years as an important teleost fish hormone, but only recently has it been recognized as the endogenous ligand of a new human G‐protein‐coupled receptor (GPCR) homologous to the GPR14 orphan receptor from rat.
CAROTENUTO, ALFONSO +3 more
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A Helical Peptide Receptor for [60]Fullerene
Chemistry - A European Journal, 2002Two terminally blocked nonapeptides, each made up of six Aib residues, a Gly spacer and two L-Tyr residues in positions 2 and 8 (these are substituted in the side chain with either ferrocenoyl or methyl moieties), have been synthesized by solution methods and fully characterized.
A. BIANCO +6 more
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Peptide receptor imaging and therapy.
Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 2000This article reviews the results of somatostatin receptor imaging (SRI) in patients with somatostatin receptor-positive neuroendocrine tumors, such as pituitary tumors, endocrine pancreatic tumors, carcinoids, gastrinomas, and paragangliomas, or other diseases in which somatostatin receptors may also be expressed, like sarcoidosis and autoimmune ...
Kwekkeboom, Dik +2 more
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Peptide-Receptor Ligands and Multivalent Approach
Anti-Cancer Agents in Medicinal Chemistry, 2012The overexpression of peptide receptors in human tumours makes peptide-ligands attractive agents for the development of specific diagnostic imaging and/or therapy of cancers. Solid-phase peptide synthesis, modern phage display technology and combinatorial peptide chemistry have profoundly affected the pool of available targeting peptides for efficient ...
Ruzza Paolo +3 more
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