Results 21 to 30 of about 28,584 (233)

Soluble epoxide hydrolase maintains steady-state lipid turnover linked with autocrine signaling in peritoneal macrophages

iScience, 2023
Summary: Soluble epoxide hydrolase is a widely distributed bifunctional enzyme that contains N-terminal phosphatase (N-phos) and C-terminal epoxide hydrolase (C-EH) domains.
Feng Liu, Xueying Diao, Haolun Cong, Eriko Suzuki, Keiji Hasumi, Hiroshi Takeshima   +5 more
doaj   +1 more source

Bee Venom Phospholipase A2 Induces Regulatory T Cell Populations by Suppressing Apoptotic Signaling Pathway

Toxins, 2020
Bee venom phospholipase A2 is a lipolytic enzyme in bee venom that catalyzes hydrolysis of the sn-2 ester bond of membrane phospholipids to produce free fatty acid and lysophospholipids.
Hyunjung Baek, Seon-Young Park, Su Jeong Ku, Kihyun Ryu, Younsub Kim, Hyunsu Bae, Ye-Seul Lee   +6 more
doaj   +1 more source

Lysosome-Dependent LXR and PPARδ Activation Upon Efferocytosis in Human Macrophages

Frontiers in Immunology, 2021
Efferocytosis is critical for tissue homeostasis, as its deregulation is associated with several autoimmune pathologies. While engulfing apoptotic cells, phagocytes activate transcription factors, such as peroxisome proliferator-activated receptors (PPAR)
Ana Carolina Mota, Monica Dominguez, Andreas Weigert, Ryan G. Snodgrass, Dmitry Namgaladze, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne, Bernhard Brüne   +8 more
doaj   +1 more source

Mammalian Phospholipase A2: Phospholipase A2 Receptor

Biological and Pharmaceutical Bulletin, 2004
The phospholipase A2 receptor (PLA2R) is a type I transmembrane glycoprotein related to the C-type animal lectin family such as the mannose receptor. PLA2R regulates a variety of biological responses elicited by secretory phospholipase A2s (sPLA2s). Group IB sPLA2 acts as an endogenous ligand to induce cell proliferation and lipid mediator production ...
openaire   +3 more sources

Treatment of phospholipase A2 receptor associated membranous nephropathy with obinutuzumab: a report of ten cases with a literature review

Linchuang shenzangbing zazhi
Objective To explore the efficacy and safety of obinutuzumab (OBZ) for phospholipase A2 receptor（PLA2R）-associated membranous nephropathy (MN) with an intermediate-to-high risk of progression.
Miao Yan, Wei Liang
doaj   +1 more source

Inhibition of nicotinic acetylcholine receptors, a novel facet in the pleiotropic activities of snake venom phospholipases A2.

PLoS ONE, 2014
Phospholipases A2 represent the most abundant family of snake venom proteins. They manifest an array of biological activities, which is constantly expanding. We have recently shown that a protein bitanarin, isolated from the venom of the puff adder Bitis
Catherine A Vulfius, Igor E Kasheverov, Vladislav G Starkov, Alexey V Osipov, Tatyana V Andreeva, Sergey Yu Filkin, Elena V Gorbacheva, Maxim E Astashev, Victor I Tsetlin, Yuri N Utkin   +9 more
doaj   +1 more source

Activation of phospholipase D-2 by P2X7 agonists in rat submandibular gland acini

Journal of Lipid Research, 2002
Exogenous ATP stimulated phospholipase D (PLD), but not sphingomyelinase in rat submandibular gland (SMG) acini. PLD activation was dependent upon extracellular Ca2+ and did not involve intracellular Ca2+ mobilization or phosphoinositide-specific ...
Encarnación Pérez-Andrés, María Fernández-Rodriguez, Mónica González, Ana Zubiaga, Ainara Vallejo, Itxaso García, Carlos Matute, Stéphanie Pochet, Jean Paul Dehaye, Miguel Trueba, Aida Marino, Antonio Gómez-Muñoz   +11 more
doaj   +1 more source

P2 Receptors and Platelet Activation

The Scientific World Journal, 2002
Adenosine diphosphate (ADP) plays a crucial role in hemostasis and thrombosis by activating platelets. In platelets, the classical P2T receptor is now resolved into three P2 receptor subtypes: the P2Y1, the P2Y12, and the P2X1 receptors.
Satva P. Kunapuli
doaj   +1 more source

A rare case of PLA2R- and THSD7A-positive idiopathic membranous nephropathy

Brazilian Journal of Nephrology, 2019
Idiopathic membranous nephropathy (IMN) is a frequent cause of nephrotic syndrome in adults. In terms of etiology, the condition may be categorized as primary/idiopathic or secondary. Literature on the pathophysiology of IMN has indicated the presence of
David Campos Wanderley, Bárbara Dornelas Jones, Fabricio Augusto Marques Barbosa, Stanley de Almeida Araujo   +3 more
doaj   +2 more sources

Anti-phospholipase A2 Receptor Antibody and Immunosuppression in Membranous Nephropathy [PDF]

Journal of the American Society of Nephrology, 2015
In the 6 years since the discovery of anti-phospholipase A2 receptor (anti-PLA2R) antibodies in the majority of patients with primary membranous nephropathy (MN),1 our understanding of the role of anti-PLA2R in clinical disease has evolved rapidly. The initial small retrospective clinical studies indicated that anti-PLA2R levels could be modulated by ...
openaire   +2 more sources