Results 31 to 40 of about 28,584 (233)

Anti-Phospholipase A2 Receptor Antibodies and the Pathogenesis of Membranous Nephropathy [PDF]

Nephron Clinical Practice, 2014
Since the early 2000s, considerable advances have been achieved in the understanding of molecular pathomechanisms of human membranous nephropathy (MN), inspired by studies of Heymann nephritis, a faithful experimental model. These studies led to the identification of neutral endopeptidase, the type-M phospholipase A₂ receptor ...
Pierre, Ronco, Hanna, Debiec
openaire   +2 more sources

Clear cell renal cell carcinoma complicated with PLA2R-associated membranous nephropathy：three cases report and literature review

Linchuang shenzangbing zazhi
ObjectiveTo explore the clinical characteristics， treatment and outcomes of renal cell carcinoma （RCC） combined with phospholipase A2 receptor （PLA2R）-related membranous nephropathy （MN）.MethodsThe clinical and pathological data， diagnosis， treatment ...
Sun Miao-xin, Wu Hao-wen, Wang Ding-ding, Wang Shuang-yu, Chai Wen-xiu, Li Yun, Li Zi-wei, Duan Li-ping   +7 more
doaj   +3 more sources

Therapeutic advances of rituximab alone or plus other drugs for membranous nephropathy

Linchuang shenzangbing zazhi
Membranous nephropathy （MN） is a common pathological type of adult nephrotic syndrome. According to the etiology, MN is divided into idiopathic membranous nephropathy （IMN） and secondary membranous nephropathy （SMN）.
Chao Zhang, Hui Liao, Rong-shan Li
doaj   +1 more source

The Spectrum of Biopsy‐Proven Renal Diseases in Chinese Elderly Patients and Its Temporal Shift Over 20 Years: A Retrospective Cohort Study

AGING MEDICINE, EarlyView.
This 20‐year retrospective study reveals a significant increase in renal biopsy utilization and a pivotal shift in biopsy‐proven renal disease among Chinese elderly patients. Secondary glomerular nephropathy (particularly diabetic nephropathy and hypertensive nephropathy) has surpassed primary glomerular nephropathy as the leading biopsy‐proven ...
Shasha Han, Lengnan Xu, Ying Sun, Fang Fang, Xin Liu   +4 more
wiley   +1 more source

Targeting the phospholipase A2 receptor ameliorates premature aging phenotypes [PDF]

Aging Cell, 2018
AbstractHutchinson–Gilford progeria syndrome (HGPS) is a lethal premature aging that recapitulates many normal aging characteristics. This disorder is caused by mutation in the LMNA gene leading to the production of progerin which induces misshapen nuclei, cellular senescence, and aging.
Griveau, Audrey, Wiel, Clotilde, Le Calvé, Benjamin, Ziegler, Dorian, Djebali, Sophia, Warnier, Marine, Martin, Nadine, Marvel, Jacqueline, Vindrieux, David, Bergo, Martin, Bernard, David   +10 more
openaire   +5 more sources

Platelet calcium signaling by G-protein coupled and ITAM-linked receptors regulating anoctamin-6 and procoagulant activity

Platelets, 2021
Most agonists stimulate platelet Ca2+ rises via G-protein coupled receptors (GPCRs) or ITAM-linked receptors (ILRs). Well studied are the GPCRs stimulated by the soluble agonists thrombin (PAR1, PAR4), ADP (P2Y1, P2Y12), and thromboxane A2 (TP ...
Delia I. Fernández, Marijke J. E. Kuijpers, Johan W. M. Heemskerk   +2 more
doaj   +1 more source

Mechanistic investigation of Liujing Toutong tablet in the treatment of cerebral ischemia–reperfusion injury in rats by the integration of serum pharmacochemistry and metabolomics

Animal Models and Experimental Medicine, EarlyView.
The research strategy for pharmacodynamics, serum pharmacochemistry, metabolomics, and network pharmacology analysis method in intervention effects of LTT are illustrated. Abstract Background Liujing Toutong tablet (LTT) is a traditional Chinese patent medicine.
Zihan Yu, Ke Pei, Xiulin Wang, Wenling Li, Hongchang Li, Wangyang Xie, Xianglong Meng, Tingting Zhao, Yan Ning, Haixin Liu, Wenbin He   +10 more
wiley   +1 more source

Vasoconstrictor effect of Africanized honeybee (Apis mellifera L.) venom on rat aorta

Journal of Venomous Animals and Toxins including Tropical Diseases, 2013
Background : Apis mellifera stings are a problem for public health worldwide, particularly in Latin America due to the aggressiveness of its Africanized honeybees. Massive poisoning by A.
Paulo César P Sousa, Teresinha S Brito, Daniel S Freire, Rafael M Ximenes, Pedro Jorge C Magalhães, Helena SA Monteiro, Renata S Alves, Alice Maria C Martins, Daniela O Toyama, Marcos H Toyama   +9 more
doaj   +1 more source

Therapeutic Applications of Stimuli‐Based Release and Engineering of Extracellular Vesicles

Advanced NanoBiomed Research, EarlyView.
This review summarizes the effects of endogenous and exogenous stimuli, their effects on the natural release of extracellular vesicles, as well as their uptake and release. It also gives an overview of stimuli‐responsive EVs and their therapeutic applications. Extracellular vesicles (EVs), nano‐ to microsized lipid bilayer membrane‐bound particles, are
Gloria Kemunto, Kristen Dellinger
wiley   +1 more source

Phospholipases and the network of auxin signal transduction with ABP1 and TIR1 as two receptors: a comprehensive and provocative model

Frontiers in Plant Science, 2012
Phospholipase D (PLD), secreted phospholipase A2 (sPLA2) and patatin-related phospholipase A (pPLA) are important elements in auxin signal transduction. PLDζ2 has a function in auxin transport.
Günther F. E. Scherer, Corinna eLabusch, Yunus eEffendi   +2 more
doaj   +1 more source