Results 41 to 50 of about 28,584 (233)

Perioperative Intravenous Dexamethasone Improves Pain and Functional Outcomes After Arthroscopic Rotator Cuff Repair

Arthroscopy, Sports Medicine, and Rehabilitation, EarlyView.
Purpose To evaluate the effect of perioperative dexamethasone on patient‐reported pain, functional outcomes, and minimal clinically important difference (MCID) achievement following arthroscopic rotator cuff repair. Methods Patients who underwent rotator cuff repair between 2013 and 2023 were identified and divided into groups.
Trevor D. Wolterink, Germain Craddock, Joshua P. Castle, Michael A. Gaudiani, Chimdindu Obinero, Alexander S. Jurayj, Christian A. Freitag, Nathan Y. Li, Jared Mahylis, Stephanie J. Muh   +9 more
wiley   +1 more source

Research advances of obinutuzumab in the treatment of membranous nephropathy

Linchuang shenzangbing zazhi
Membranous nephropathy （MN） is a common cause of adult nephrotic syndrome. Rituximab, a type Ⅰ anti-CD20 monoclonal antibody, is an effective treatment of MN.
Xiao-jing Lin, Jing Sun, Hao-yi Xiangli, Xuan-yi Du   +3 more
doaj   +1 more source

A Multifaceted Interplay Among Hemophagocytosis, Interleukin‐18, and Type I Interferon Distinguishes Still Disease From Other Autoinflammatory Diseases

Arthritis &Rheumatology, EarlyView.
Objective The unknown pathophysiology and the lack of specific features for systemic juvenile idiopathic arthritis and adult‐onset Still disease (collectively known as Still disease; SD) delay diagnosis and appropriate treatment. The goal of this study was to identify features and mechanisms that distinguish SD from other systemic autoinflammatory ...
Yvonne M. Mueller, Charlotte Girard, Harmen J. G. van de Werken, Stefan J. Erkeland, Dwin G. B. Grashof, Laurie Vaillant, Renske J. H. den Dekker, Iris van Zuijen, Sharon Veenbergen, Fanny Coffin, Eric Bindels, Yvan Jamilloux, Katerina Laskari, Vassili Soumelis, Bruno Fautrel, Cem Gabay, Peter D. Katsikis   +16 more
wiley   +1 more source

DioxolaneA3-phosphatidylethanolamines are generated by human platelets and stimulate neutrophil integrin expression

Redox Biology, 2017
Activated platelets generate an eicosanoid proposed to be 8-hydroxy-9,10-dioxolane A3 (DXA3). Herein, we demonstrate that significant amounts of DXA3 are rapidly attached to phosphatidylethanolamine (PE) forming four esterified eicosanoids, 16:0p, 18:0p,
Maceler Aldrovandi, Christine Hinz, Sarah N. Lauder, Helen Podmore, Martin Hornshaw, David A. Slatter, Victoria J. Tyrrell, Stephen R. Clark, Lawrence J. Marnett, Peter W. Collins, Robert C. Murphy, Valerie B. O’Donnell   +11 more
doaj   +1 more source

Adenosine stimulates the basolateral 50 pS K+ channel in renal proximal tubule via adenosine-A1 receptor

Frontiers in Physiology, 2023
Background: The basolateral potassium channels play an important role in maintaining the membrane transport in the renal proximal tubules (PT) and adenosine receptors have been shown to regulate the trans-epithelial Na+ absorption in the PT.
Hao Liu, Qi Sun, Zheng Ding, Wensen Shi, Wen-Hui Wang, Chengbiao Zhang   +5 more
doaj   +1 more source

Resistance to Endotoxic Shock in Phospholipase A2 Receptor-deficient Mice [PDF]

Journal of Biological Chemistry, 1997
Mammals possess various types of secretory phospholipase A2, which differ in the primary structure and tissue distribution. The phosholipase A2 receptor (PLA2R) recognizes group IB phospholipase A2 (PLA2-IB) and mediates the PLA2-IB-induced biological responses in non-digestive organs, including eicosanoid production and contraction of airway smooth ...
K, Hanasaki, Y, Yokota, J, Ishizaki, T, Itoh, H, Arita   +4 more
openaire   +2 more sources

Advancing design strategies in smart stimulus‐responsive liposomes for drug release and nanomedicine

BMEMat, EarlyView.
Schematic illustration of stimulus‐responsive liposomes designed for controlled drug release and nanomedicine. The innermost circle represents different liposomal structures, including unilamellar, multilamellar, and multivesicular liposomes. The middle layer illustrates the responsive phospholipid components.
Yuchen Guo, Nan Li, Daiwei Zhang, Jingya Gu, Zhihuan Liao, Zihao Teng, Xiangfu Du, Peter S. Timashev, Shipeng Chen, Shuaidong Huo   +9 more
wiley   +1 more source

PLA2R-associated membranous nephropathy associated with renal clear cell carcinoma: one case report

Linchuang shenzangbing zazhi, 2021
临床资料患者,男,40岁,因"双下肢水肿2个月余"于2019年4月30日入院。入院体格检查:血压 160/82 mmHg（1 mmHg=0.133 kPa）,全身皮肤黏膜色泽正常,心、肺、腹无特殊,双下肢中度凹陷性水肿。入院后查尿潜血（++）,尿蛋白（+++）,24 h尿蛋白定量7 g, 血红蛋白119 g/L,白蛋白18.12 g/L,总胆固醇5.79 mmol/L,低密度脂蛋白胆固醇4.50 mmol/L,
Xu Xiao-chang, Dong Ye-jing, Ju Lang, Zhang Yi-min   +3 more
doaj  

Coupling of two pools of P2X7 receptors to distinct intracellular signaling pathways in rat submandibular gland

Journal of Lipid Research, 2006
The plasma membrane of cells from rat submandibular glands was isolated and extensively sonicated. The homogenate was centrifuged at high speed in a discontinuous sucrose gradient.
Mikel Garcia-Marcos, Encarnacioén Peérez-Andreés, Seéverine Tandel, Unai Fontanils, Alain Kumps, Elie Kabreé, Antonio Goémez-Muñoz, Aida Marino, Jean-Paul Dehaye, Steéphanie Pochet   +9 more
doaj   +1 more source

Pt‐TiO2 mesoporous nanosystem co‐delivering phlorezin enables synergistic sonodynamic‐chemoimmunotherapy for hepatocellular carcinoma via directly targeting DDX5 and metabolic reprogramming modulation

BMEMat, EarlyView.
Abstract Hepatocellular carcinoma (HCC), ranking as the third leading cause of cancer‐related mortality globally, continues to pose significant therapeutic challenges. Here, we developed an innovative nanosystem, Phl@PT, based on Pt‐TiO2 nanoparticles for the co‐delivery of Phlorezin, presenting a novel approach for HCC treatment through sonodynamic ...
Kairui Liu, Bo Zhang, Yue Wan, Zhiru Yang, Abdusami Abdurahman, Mengxin He, Shengtao Hu, Yi Zhang, Xiaoke Li, Jin Chang, Jun Kang, Liren Liu, Wanghua Liu, Shao Li   +13 more
wiley   +1 more source