Results 251 to 260 of about 724,506 (298)
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Progesterone-Progestin Receptors
1974A correlation between binding to the progestin-specific uterine cytosol receptor and with well-defined facets of progesterone action was established. Structurally similar derivatives of norprogesterone and nortestosterone were compared. Binding was measured in vitro by determining their competitive effect on the progestin-tagged uterine cytosol ...
J P, Raynaud +2 more
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Progesterone Receptors and Ovulation
2010The steroid hormone, progesterone, plays a critical role in the regulation of female ovulation. The physiological effects of progesterone are mediated by two nuclear receptor transcription factors, PR-A and PR-B, which are produced from a single gene and upon binding progesterone regulate the expression of specific gene networks in reproductive tissues.
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Progesterone antagonists and progesterone receptor modulators: an overview
Steroids, 2003Since the original description of the structure of the antiprogestin, mifepristone, was published, numerous related compounds have been synthesized which may function as progesterone antagonists (PAs) or progesterone receptor modulators (PRMs). The latter are mixed agonists-antagonists.
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Progesterone ”Receptor“ in Rat Ovary*
Endocrinology, 1979A soluble thermolabile protein with many characteristics of a progesterone receptor has been identified in ovaries of estrogen-stimulated, hypophysectomized, immature female rats. A potent synthetic progestin R5020 (17,21-dimethyl-19-nor-pregna-4, 9-diene-3, 20-dione) and a progestin-receptor complex stabilizer (glycerol) were employed.
J R, Schreiber, J W, Hsueh
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Progesterone Receptor Signaling Mechanisms
Journal of Molecular Biology, 2016Progesterone receptor (PR) is a master regulator in female reproductive tissues that controls developmental processes and proliferation and differentiation during the reproductive cycle and pregnancy. PR also plays a role in progression of endocrine-dependent breast cancer.
Sandra L, Grimm +2 more
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Activation of Progesterone Receptor by ATP
European Journal of Biochemistry, 1981Progesterone-receptor complex from freshly prepared hen oviduct cytosol acquired the ability to bind to isolated nuclei, DNA-cellulose and ATP-Sepharose when incubated with 5-10 mM ATP at 4 degrees C. The extent of this ATP-dependent activation was higher when compared with heat-activation achieved by warming the progesterone-receptor complex at 23 ...
V, Moudgil +5 more
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Progesterone Receptors in Rat Thymus
Endocrinology, 1983Tritiated promegestone ([3H]R5020) is bound with high affinity in cytosol prepared from the thymus gland of both male and female rats. To prevent tracer binding to glucocorticoid receptors, we have used excess RU26988 (11 beta, 17 beta-dihydroxy-21-methyl-17 alpha-pregna-1,4,6-trien-20-yn-3-one), a highly specific synthetic glucocorticoid.
P T, Pearce, B A, Khalid, J W, Funder
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Progesterone and the progesterone receptor.
The Journal of reproductive medicine, 2001During the 1990s, extensive research has effectively mapped the progesterone receptor-mediated actions of progesterone and has more recently uncovered nonreceptor-mediated effects--the effect of progesterone on uterine sensitivity to oxytocin, for example, involves direct, nongenomic progesterone action on the uterine oxytocin receptor.
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PROGESTERONE RECEPTORS IN BREAST CANCER
Australian and New Zealand Journal of Surgery, 1984Sixty‐six women who had received hormonal therapy for advanced disease were assessed for objective response to treatment. Another 51 patients who had received chemotherapy were similarly studied. Progesterone receptor was of no value as a predictor of patients unlikely to respond to hormone therapy, though it may have a role in predicting patients ...
R M, Bryan +5 more
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Estrogen and progesterone receptors in meningiomas
Surgical Neurology, 1986Estradiol and progesterone receptors were studied in 14 patients with meningiomas. Estrogen receptors were detected by specific monoclonal antibodies, whereas progesterone receptors were assayed by the dextran-coated charcoal method. In 9 cases the estrogen receptors were also investigated in cultured tumor cells.
MAIURI, FRANCESCO +2 more
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