Reproductive functions of the progesterone receptor
Journal of the Society for Gynecologic Investigation, 2000 The steroid hormone progesterone plays a central role in the reproductive events associated with pregnancy establishment and maintenance. Physiological effects of progesterone are mediated by interaction of the hormone with specific intracellular progesterone receptors (PRs) that are expressed as two protein isoforms, PR-A and PR-B. Both proteins arise
Conneely, O.M. +4 more
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Progesterone Regulation of the Progesterone Receptor in Rat Gonadotropes* [PDF]
Endocrinology, 2000 For rat pituitary cells, progesterone receptor (PR) protein localizes to gonadotropes and PR messenger RNA is induced by E2 and rapidly but transiently down-regulated by progesterone. Here we quantitatively establish the down-regulatory effect of progesterone on PR protein and evaluate possible mechanisms.
J L, Turgeon, D W, Waring
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Expression of nuclear progesterone receptors (nPR), membrane progesterone receptors (mPR) and progesterone receptor membrane components (PGRMC) in the human endometrium after 6 months levonorgestrel low dose intrauterine therapy [PDF]
, 2020 The classical steroid receptors (nuclear receptors), including those for progesterone (nPRs), are thoroughly characterized. The knowledge about so-called non-genomic effects, which are mediated by extra-nuclear initiated signals, has increased immensely ...
Ørbo, Anne +3 more
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Progesterone receptors in normal breast development and breast cancer [PDF]
, 2021 Progesterone receptors (PR) play a pivotal role in many female reproductive tissues such as the uterus, the ovary, and the mammary gland (MG). Moreover, PR play a key role in breast cancer growth and progression. This has led to the development and study
Giulianelli, Sebastian Jesus +2 more
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Estrogen and Progesterone Receptors in Human Colorectal Tumour Cells (Study of 70 Cases)
The International Journal of Biological Markers, 1988 Estrogen and progesterone receptors were studied in 70 cases of human colorectal cancer by a cytochemical technique. 28.5% of the cases were estrogen-receptor positive and 42.8% progesterone-receptor positive.
G. Bracali +5 more
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Rodent Models of Non-classical Progesterone Action Regulating Ovulation
Frontiers in Endocrinology, 2017 It is becoming clear that steroid hormones act not only by binding to nuclear receptors that associate with specific response elements in the nucleus but also by binding to receptors on the cell membrane. In this newly discovered manner, steroid hormones
Melinda A. Mittelman-Smith +3 more
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Rapid progesterone actions on thymulin-secreting epithelial cells cultured from rat thymus [PDF]
, 1999 Many soluble factors of neural, endocrine, paracrine and autocrine origin are present in the thymus and modulate its function. Long-term effects of sex steroids have! been documented for thymocytes and cells of the thymic microenvironment. In this report
Downing, James E. G. +4 more
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The role of progesterone in the regulation of ciliary activity in the fallopian tube [PDF]
, 2009 The overall aim of this thesis was to investigate the distribution and regulation of membrane progesterone receptors (mPRs) that may be involved in regulating ciliary activity in the fallopian tube.
Nutu, Magdalena
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Internalisation of membrane progesterone receptor-α after treatment with progesterone: Potential involvement of a clathrin-dependent pathway [PDF]
, 2010 This article has been made available through the Brunel Open Access Publishing Fund.Internalisation and recycling of seven trans-membrane domain receptors is a critical regulatory event for their signalling.
Reynolds, A +5 more
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Changes in ovaries and uterus after aglepristone administration in the third week of luteal phase of non-pregnant bitches. [PDF]
PLoS ONE, 2015 The mechanism of aglepristone action in the placentation time in the bitch remains unclear. The aim of this study was to describe the mechanism by which aglepristone influences ovaries and uterus and to measure the levels of steroid sex hormones in non ...
Kamil Kacprzak +5 more
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