Results 41 to 50 of about 724,506 (298)

Steroid hormone bioavailability is controlled by the lymphatic system

Scientific Reports, 2021
The steroid hormone progesterone accounts for immune tolerance in pregnancy. Enhanced progesterone metabolism to 6α-OH-pregnanolone occurs in complicated pregnancies such as in preeclampsia with preterm delivery or intrauterine growth restriction, and in
Rahel Klossner, Michael Groessl, Nadine Schumacher, Michaela Fux, Geneviève Escher, Sophia Verouti, Heidi Jamin, Bruno Vogt, Markus G. Mohaupt, Carine Gennari-Moser   +9 more
doaj   +1 more source

Human amniotic fluid glycoproteins expressing sialyl Lewis carbohydrate antigens stimulate progesterone production in human trophoblasts in vitro [PDF]

, 2004
Background: Progesterone is thought to mediate immune modulator effects by regulating uterine responsiveness. The aim of the study was to clarify the effect of transferrin and glycodelin A (former name PP14) as sialyl Lewis X-expressing glycoproteins on ...
Streu, Annett, Richter, Dagmar-Ulrike, Volker Briese, Jeschke, Udo, Klaus Friese, Ioannis Mylonas, Annett Streu, Udo Jeschke, Briese, Volker, Mylonas, Ioannis, Müller, Heiner, Dagmar-Ulrike Richter, Friese, Klaus, Heiner Müller   +13 more
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Steroids, Pregnancy and Fetal Development

Frontiers in Immunology, 2020
Maternal glucocorticoids critically rise during pregnancy reaching up to a 20-fold increase of mid-pregnancy concentrations. Concurrently, another steroid hormone, progesterone, increases.
Maria Emilia Solano, Petra Clara Arck
doaj   +1 more source

Identification of a novel corticotropin-releasing hormone type 1 beta-Like receptor variant lacking exon 13 in human pregnant myometrium regulated by estradiol-17 beta and progesterone [PDF]

, 2010
Two types of CRH receptors mediate the diverse biological functions of CRH and CRH-related peptides. The type 1 CRH-R (CRH-R1) is extensively targeted by pre-mRNA splicing mechanisms that give rise to multiple mRNA splice variants.
Jing Chen, Emmanouil Karteris, Markovic, Danijela, Grammatopoulos, DK, Danijela Markovic, Edward W. Hillhouse, Grammatopoulos, Dimitris, Hillhouse, EW, Chen, J, Karteris, Emmanouil, Dimitris K. Grammatopoulos, Markovic, D, Hillhouse, Edward W., Chen, Jing   +13 more
core   +1 more source

Revisiting the roles of progesterone and allopregnanolone in the nervous system: Resurgence of the progesterone receptors [PDF]

, 2014
Progesterone is commonly considered as a female reproductive hormone and is well-known for its role in pregnancy. It is less well appreciated that progesterone and its metabolite allopregnanolone are also male hormones, as they are produced in both sexes
Ghoumari, Abdel M., Guennoun, Rachida, Labombarda, Florencia, Oudinet, J.P., Schumacher, Michael, De Nicola, Alejandro, Mattern, Claudia, Sitruk-Ware, Régine   +7 more
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A nongenomic mechanism for progesterone-mediated immunosuppression: Inhibition of K+ channels, Ca2+ signaling, and gene expression in T lymphocytes [PDF]

, 1998
The mechanism by which progesterone causes localized suppression of the immune response during pregnancy has remained elusive. Using human T lymphocytes and T cell lines, we show that progesterone, at concentrations found in the placenta, rapidly and ...
Christopher M. Fanger, Khoury, Rosana M, Negulescu, Paul A, Cahalan, Michael D, Neben, Amber L, Hubert H. Kerschbaum, Fanger, Christopher M, Rosana M. Khoury, Kerschbaum, Hubert H, Claudia Eder, Amber L. Neben, George R. Ehring, Eder, Claudia, Michael D. Cahalan, Paul A. Negulescu, Ehring, George R, Negulescu, PA, Fanger, CM, Kerschbaum, HH, Khoury, RM, Ehring, GR, Eder, C, Cahalan, MD, Neben, AL   +23 more
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Progesterone modulates neuronal excitability bidirectionally

, 2021
•Progesterone regulation of neuronal activity and seizures.•Progesterone receptor activation exerts seizure-promoting effects.•Progesterone receptor activation could contribute to catamenial seizure exacerbation.•Allopregnanolone suppresses seizure ...
Joshi, Suchitra, Jaideep Kapur, Kapur, Jaideep, Suchitra Joshi   +3 more
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Estrogen and Progesterone Receptors in the Endometrium

Annals of the New York Academy of Sciences, 1997
The endometrium, as a target of estrogens and progestins, possesses the respective receptor proteins. These receptors belong to the superfamily of nuclear receptors, having important functional domains required for steroid ligand binding, for dimer formation, for interaction with HREs of DNA, for transcription modulation, for association with other ...
Moutsatsou, P., Sekeris, C.E.
openaire   +4 more sources

The androgen and progesterone receptors regulate distinct gene networks and cellular functions in decidualizing endometrium [PDF]

, 2008
Progesterone is indispensable for differentiation of human endometrial stromal cells (HESCs) into decidual cells, a process that critically controls embryo implantation.
Cartwright, JE, Yliheikkila, M., Marius C. Jones, Lam, Eric W.-F., Eric W.-F. Lam, Matti Poutanen, Fusi, L, Luca Fusi, Kim, J. J., Ho, K.-K., Teklenburg, G., Kim, JJ, Poutanen, M, Trew, G, Lavery, S., Cartwright, J. E., Judith E. Cartwright, Cloke, B, Kajihara, T, Geoffrey Trew, Takeshi Kajihara, Huhtinen, K., Jones, M. C., Stuart Lavery, Lam, EW, Jan J. Brosens, Huhtinen, K, Lavery, S, J. Julie Kim, Trew, G., Poutanen, M., Kaisa Huhtinen, Kajihara, T., Brosens, Jan J., Cloke, B., Ho, KK, Teklenburg, G, Jones, MC, Brosens, JJ, Yliheikkilä, M, Maria Yliheikkilä, Gijs Teklenburg, Brianna Cloke, Ka-Kei Ho, Fusi, L.   +44 more
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N-glycans of human amniotic fluid transferrin stimulate progesterone production in human first trimester trophoblast cells in vitro [PDF]

, 2004
Aims: During pregnancy, the placenta produces a variety of steroid hormones and proteins. Several of these substances have been shown to exert immunomodulatory effects.
Briese, V., Friese, K., Richter, D.-U., Gundel, G., Mylonas, I., Unverzagt, C., Jeschke, U., Müller, H., Streu, A.   +8 more
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