Results 61 to 70 of about 724,506 (298)

Beta1 subunits enable fentanyl‐induced BK channel activation and opioid regulation of cerebral artery diameter

open access: yesFEBS Open Bio, EarlyView.
During the current opioid crisis, the majority of overdose deaths are attributed to ultra‐potent synthetic opioids, such as fentanyl. While fentanyl exerts its action via opioid receptors, we propose that potassium channels in the brain blood vessels may also sense fentanyl.
Shiwani Thapa   +4 more
wiley   +1 more source

Survival Outcomes in Older Adults With Axial Spondyloarthritis and Concomitant Cancer

open access: yesArthritis Care &Research, EarlyView.
Objective The objective of this study was to determine survival outcomes in older adults with axial spondyloarthritis (axSpA) and concomitant cancer. Methods We conducted a population‐based study using Medicare claims data linked to Surveillance, Epidemiology, and End Results data to determine overall survival (OS) and cancer‐specific survival (CSS) in
Savannah Bowman   +7 more
wiley   +1 more source

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

open access: yesAdvanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez   +8 more
wiley   +1 more source

Characterization of membrane-associated non-genomic progesterone receptors in cattle bull spermatozoa

open access: yesIndian Journal of Animal Sciences
The present study aimed to examine the molecular existence of the non-genomic progesterone receptors (P4) and their location in Hariana bull spermatozoa.
VIKAS SACHAN   +6 more
doaj   +1 more source

Immune Aspects and Myometrial Actions of Progesterone and CRH in Labor

open access: yesClinical and Developmental Immunology, 2012
Progesterone and corticotropin-releasing hormone (CRH) have a critical role in pregnancy and labor, as changes related to these hormones are crucial for the transition from myometrial quiescence to contractility.
Nikolaos Vrachnis   +4 more
doaj   +1 more source

Therapeutic effects of progesterone and its metabolites in traumatic brain injury may involve non-classical signaling mechanisms

open access: yesFrontiers in Neuroscience, 2013
Traumatic brain injury is an important and costly medical problem for which no clinically proven treatment currently exists. Studies in rodents and humans have shown beneficial effects of progesterone (P4) on both mortality and functional outcomes ...
Paul S. Cooke
doaj   +1 more source

Effect of Estrogen Progesterone LH and FSH on Oxidant and Antioxidant Parameters in Rat Uterine Tissue [PDF]

open access: yesInternational Journal of Fertility and Sterility, 2009
Background To attain whether the effects of low and high doses of estrogen progesterone luteinizing hormone (LH) and follicle stimulating hormone (FSH) in acute and chronic administration were related to oxidant and antioxidant parameters in rat uterine ...
Bunyamin Borekci   +7 more
doaj   +1 more source

An Anti‐Amyloidogenic Approach to Specifically Block Memory Consolidation in Mice for Therapeutic Intervention

open access: yesAdvanced Science, EarlyView.
Functional amyloid conversion of the translation regulator CPEB3 is essential for long‐term memory persistence. This study demonstrates that targeting this molecular switch with the anti‐amyloidogenic peptide QBP1 selectively blocks CPEB3 fibrillation without disrupting phase separation.
Paula López‐García   +13 more
wiley   +1 more source

Special aspects of steroid hormone receptors’ expression in cases of cervical intraepithelial neoplasia depending on the papillomavirus infection progression in women with infertility

open access: yesRegulatory Mechanisms in Biosystems, 2020
The relevance of the study is contingent on insufficient study of the correlation between the reception of uterine cervix steroid hormones in cases of cervical intraepithelial neoplasia (CIN) and the level of human papilloma virus load in women with ...
E. O. Kindrativ   +2 more
doaj   +1 more source

Concerted action of human chorionic gonadotropin and norepinephrine on intracellular-free calcium in human granulosa-lutein cells [PDF]

open access: yes, 1993
Luteal cells are known to possess receptors for LH/hCG and receptors of the beta-adrenergic type. Interactions of specific agonists with either receptor lead to the activation of adenylate cyclase and subsequently to an increase of cAMP.
Föhr, K. J.   +5 more
core   +1 more source

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